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Study · Animal study (in vivo) · rat · 2011

7 results

Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area.

Succu S, Sanna F, Argiolas A, Melis MR

Neuropharmacology7 Apr 2011Cited by 29 (Europe PMC)

PMID21496460 (opens in a new tab)DOI10.1016/j.neuropharm.2011.03.026 (opens in a new tab)PepBankPUB-21496460
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, oxytocin injected into the ventral subiculum induced penile erection episodes starting 30 minutes after treatment.

    In plain wordsIn male rats, oxytocin injected into a brain area induced penile erections.

    Peptide
    Oxytocin
    Outcome
    IncreasePenile erection episodes
    Study

    ratn: not reported in source

    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    100 ng · unilateral injection into the ventral subiculum of the hippocampusAs given in this study (rat).

    Source sentences

    Summary
    Oxytocin (100 ng) injected unilaterally into the ventral subiculum of the hippocampus induces penile erection episodes, which started 30 min after treatment
    1 context sentence
    Title · context
    Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In male rats, the oxytocin-induced penile erection episodes were abolished by prior injection of an oxytocin receptor antagonist into the ventral subiculum.

    In plain wordsIn male rats, blocking the oxytocin receptor in the same brain area stopped oxytocin-induced erections.

    Peptide
    Oxytocin
    Outcome
    No significant changePenile erection with oxytocin receptor antagonist
    Study

    ratn: not reported in source

    Comparator
    Oxytocin receptor antagonist given first
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    100 ng · unilateral injection into the ventral subiculum of the hippocampusAs given in this study (rat).

    Source sentences

    Summary
    and were abolished by the prior injection of d(CH(2))(5)Tyr(Me)(2)-Orn(8)-vasotocin (2 μg), an oxytocin receptor antagonist, into the ventral subiculum.
    1 context sentence
    Title · context
    Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In male rats, oxytocin injected into the ventral subiculum increased extracellular dopamine in the nucleus accumbens and the prelimbic medial prefrontal cortex 15 minutes before erection.

    In plain wordsIn male rats, oxytocin injected into a brain area raised dopamine in two other brain areas.

    Peptide
    Oxytocin
    Outcome
    IncreaseExtracellular dopamine in nucleus accumbens and prelimbic medial prefrontal cortex
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    100 ng · unilateral injection into the ventral subiculum of the hippocampusAs given in this study (rat).

    Source sentences

    Summary
    Oxytocin-induced penile erection occurred 15 min after the increase of the concentration of extracellular dopamine in the dialysate obtained from either the nucleus accumbens or the prelimbic medial prefrontal cortex
    1 context sentence
    Title · context
    Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In male rats, the oxytocin-induced dopamine increase was abolished by the oxytocin receptor antagonist.

    In plain wordsIn male rats, blocking the oxytocin receptor stopped the oxytocin-induced dopamine rise.

    Peptide
    Oxytocin
    Outcome
    No significant changeDopamine increase with oxytocin receptor antagonist
    Study

    ratn: not reported in source

    Comparator
    Oxytocin receptor antagonist given first
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    100 ng · unilateral injection into the ventral subiculum of the hippocampusAs given in this study (rat).

    Source sentences

    Summary
    which was also abolished by d(CH(2))(5)Tyr(Me)(2)-Orn(8)-vasotocin.
    1 context sentence
    Title · context
    Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In male rats, oxytocin injected into the ventral subiculum increased extracellular glutamic acid in the ventral tegmental area 15 minutes after injection.

    In plain wordsIn male rats, oxytocin injected into a brain area raised glutamate in the ventral tegmental area.

    Peptide
    Oxytocin
    Outcome
    IncreaseExtracellular glutamic acid in ventral tegmental area
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    100 ng · unilateral injection into the ventral subiculum of the hippocampusAs given in this study (rat).

    Source sentences

    Summary
    An increase in extracellular glutamic acid concentration was also observed in the same dialysate obtained from the ventral tegmental area
    1 context sentence
    Title · context
    Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In male rats, oxytocin injection did not increase glutamic acid in the prelimbic medial prefrontal cortex or the nucleus accumbens.

    In plain wordsIn male rats, oxytocin injected into a brain area did not raise glutamate in two other brain areas.

    Peptide
    Oxytocin
    Outcome
    No significant changeExtracellular glutamic acid in prelimbic medial prefrontal cortex and nucleus accumbens
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    100 ng · unilateral injection into the ventral subiculum of the hippocampusAs given in this study (rat).

    Source sentences

    Summary
    but not from the prelimbic medial prefrontal cortex or the nucleus accumbens in which dopamine concentration was measured, 15 min after the injection of oxytocin into the ventral subiculum.
    1 context sentence
    Title · context
    Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In male rats, the oxytocin-induced glutamic acid increase in the ventral tegmental area was abolished by the oxytocin receptor antagonist.

    In plain wordsIn male rats, blocking the oxytocin receptor stopped the oxytocin-induced glutamate rise.

    Peptide
    Oxytocin
    Outcome
    No significant changeGlutamic acid increase with oxytocin receptor antagonist
    Study

    ratn: not reported in source

    Comparator
    Oxytocin receptor antagonist given first
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    100 ng · unilateral injection into the ventral subiculum of the hippocampusAs given in this study (rat).

    Source sentences

    Summary
    This effect was also abolished by the prior injection of d(CH(2))(5)Tyr(Me)(2)-Orn(8)-vasotocin into the ventral subiculum.
    1 context sentence
    Title · context
    Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

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