In an in vitro binding assay on rat brain, semax moderately competed with the mGlu receptor ligand [G-3H]LY 354740 for receptor sites.
In plain wordsIn lab tests on rat brain tissue, semax moderately competed with a reference ligand for mGlu receptor binding sites.
- Peptide
- Semax
- Outcome
- Not applicableCompetition with [G-3H]LY 354740 at mGlu receptor binding sites
- Study
ratn: not reported in source
Radioligand binding to rat brain glutamate receptors in vitro- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- Dose not stated
Measurements
- IC50
- 33 microM
- mGlu receptor sites, competition with [G-3H]LY 354740
Source sentences
The heptapeptide drug semax was moderately competitive with [G-3H]LY 354740 for mGlu receptor sites (IC50 = 33 +/- 2.4 microM).
1 context sentence(design, population, supporting numbers)
The influence of nootropic drugs of different groups (piracetam, phenotropil, nooglutil, noopept, semax, meclofenoxate, pantocalcine, and dimebon) on the binding of the corresponding ligands to AMPA, NMDA, and mGlu receptors of rat brain has been studied by the method of radio-ligand binding in vitro.