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Study · Not a test of the peptide alone · 2011

5 results

Complex regulation of GH autofeedback under dual-peptide drive: studies under a pharmacological GH and sex steroid clamp.

Veldhuis JD, Erickson D, Miles JM, Bowers CY

American journal of physiology. Endocrinology and metabolism5 Apr 2011Cited by 8 (Europe PMC)

PMID21467302 (opens in a new tab)PMCIDPMC3118586 (opens in a new tab)DOI10.1152/ajpendo.00054.2011 (opens in a new tab)PepBankPUB-21467302
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 01HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism

    In postmenopausal women and older men, combined GHRH/GHRP‑2 stimulation, sex difference and sex hormone treatment each controlled total integrated GH recovery during feedback.

    In plain wordsIn older adults, the combined GHRH and GHRP‑2 infusion, sex and sex hormones all shaped how much growth hormone recovered.

    Peptide
    GHRP-2
    Outcome
    Not applicableTotal integrated GH recovery during feedback
    Study

    n = 25

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    By three-way ANCOVA, sex difference, sex hormone treatment, peptide stimulation, and placebo/saline responses (covariate) controlled total (integrated) GH recovery during feedback (each P < 0.001).
    1 context sentence
    Summary · context
    11 healthy postmenopausal women and 14 older men were each given 1) a single iv pulse of GH to enforce negative feedback and 2) continuous iv infusion of saline vs. combined GHRH/GHRP-2 to drive feedback escape during pharmacological estradiol (E(2); women) or testosterone (T; men) supplementation v…

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  2. 02HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism

    In postmenopausal women and older men, dual-peptide GHRH/GHRP‑2 infusion elevated nadir GH concentrations independently of testosterone or estradiol and sex.

    In plain wordsIn older adults, the combined GHRH and GHRP‑2 infusion raised the lowest growth hormone levels regardless of sex hormones.

    Peptide
    GHRP-2
    Outcome
    IncreaseNadir GH concentration under dual-peptide stimulation
    Study

    n = 25

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Both sex steroid milieu (P = 0.019) and dual-peptide stimulation (P < 0.001) determined nadir (maximally feedback-suppressed) GH concentrations. E(2)/T exposure elevated nadir GH concentrations during saline infusion (P = 0.003), whereas dual-peptide infusion did so independently of T/E(2) and sex d…
    1 context sentence
    Summary · context
    11 healthy postmenopausal women and 14 older men were each given 1) a single iv pulse of GH to enforce negative feedback and 2) continuous iv infusion of saline vs. combined GHRH/GHRP-2 to drive feedback escape during pharmacological estradiol (E(2); women) or testosterone (T; men) supplementation v…

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  3. 03HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism

    In postmenopausal women and older men, double-peptide GHRH/GHRP‑2 stimulation augmented recovery of peak GH concentrations.

    In plain wordsIn older adults, the combined GHRH and GHRP‑2 infusion increased the peak growth hormone levels reached.

    Peptide
    GHRP-2
    Outcome
    IncreasePeak GH recovery under double-peptide stimulation
    Study

    n = 25

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    All three of sex difference (P = 0.001), sex steroid treatment (P = 0.005), and double-peptide stimulation (P < 0.001) augmented recovery of peak (maximally feedback-escaped) GH concentrations.
    1 context sentence
    Summary · context
    11 healthy postmenopausal women and 14 older men were each given 1) a single iv pulse of GH to enforce negative feedback and 2) continuous iv infusion of saline vs. combined GHRH/GHRP-2 to drive feedback escape during pharmacological estradiol (E(2); women) or testosterone (T; men) supplementation v…

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  4. 04HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism

    In response to GHRH/GHRP‑2, peak GH was greater in postmenopausal women than in older men.

    In plain wordsWith the combined GHRH and GHRP‑2 infusion, women reached higher peak growth hormone than men.

    Peptide
    GHRP-2
    Outcome
    Not applicablePeak GH response to dual-peptide agonists by sex
    Study

    n = 25

    Comparator
    Men
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Peak GH responses to dual-peptidyl agonists were greater in women than in men (P = 0.016).
    1 context sentence
    Summary · context
    11 healthy postmenopausal women and 14 older men were each given 1) a single iv pulse of GH to enforce negative feedback and 2) continuous iv infusion of saline vs. combined GHRH/GHRP-2 to drive feedback escape during pharmacological estradiol (E(2); women) or testosterone (T; men) supplementation v…

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  5. 05HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism

    In postmenopausal women and older men, peptide infusion had an independent effect on the regularity of GH release.

    In plain wordsIn older adults, the combined GHRH and GHRP‑2 infusion changed how regular the growth hormone release pattern was.

    Peptide
    GHRP-2
    Outcome
    Not applicableGH regularity (approximate entropy) under peptide infusion
    Study

    n = 25

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Approximate entropy analysis corroborated independent effects of sex steroid treatment (P = 0.012) and peptide infusion (P < 0.001) on GH regularity.
    1 context sentence
    Summary · context
    11 healthy postmenopausal women and 14 older men were each given 1) a single iv pulse of GH to enforce negative feedback and 2) continuous iv infusion of saline vs. combined GHRH/GHRP-2 to drive feedback escape during pharmacological estradiol (E(2); women) or testosterone (T; men) supplementation v…

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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