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Study · Animal study (in vivo) · rat · 2011

7 results

Activity-dependent neuroprotective protein (ADNP)-derived peptide (NAP) ameliorates hypobaric hypoxia induced oxidative stress in rat brain.

Sharma NK, Sethy NK, Meena RN, Ilavazhagan G, Das M, Bhargava K

Peptides29 Mar 2011Cited by 27 (Europe PMC)

PMID21453737 (opens in a new tab)DOI10.1016/j.peptides.2011.03.016 (opens in a new tab)PepBankPUB-21453737
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hypobaric hypoxia-exposed rats, NAP improved brain antioxidant status.

    In plain wordsIn rats exposed to low-pressure hypoxia, NAP improved antioxidant status in the brain.

    Peptide
    Davunetide
    Outcome
    IncreaseBrain antioxidant status
    Study

    ratn: not reported in source

    Chronic hypobaric hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2μg/Kg body weight · intranasalAs given in this study (rat).

    Source sentences

    Summary
    Intranasal supplementation of NAP peptide (2μg/Kg body weight) improved antioxidant status of brain evaluated by biochemical assays for free radical estimation, lipid peroxidation, GSH and GSSG level.
    1 context sentence
    Summary · context
    In the present study, we have investigated the antioxidant and memory protection efficacy of the synthetic NAP peptide (NAPVSIPQ) during long-term chronic hypobaric hypoxia (7, 14, 21 and 28 days, 25,000ft) in rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, NAP significantly increased SOD expression compared with hypoxia-exposed rats.

    In plain wordsIn rats, NAP increased SOD expression compared with hypoxia-exposed rats.

    Peptide
    Davunetide
    Outcome
    IncreaseSOD expression
    Study

    ratn: not reported in source

    Chronic hypobaric hypoxia
    Comparator
    Hypoxia-exposed rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2μg/Kg body weight · intranasalAs given in this study (rat).

    Source sentences

    Summary
    Analysis of expression levels of SOD revealed that NAP significantly activated antioxidant genes as compared to hypoxia exposed rats.
    1 context sentence
    Summary · context
    In the present study, we have investigated the antioxidant and memory protection efficacy of the synthetic NAP peptide (NAPVSIPQ) during long-term chronic hypobaric hypoxia (7, 14, 21 and 28 days, 25,000ft) in rats.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In hypobaric hypoxia-exposed rats, NAP significantly increased Nrf2 expression.

    In plain wordsIn rats exposed to hypoxia, NAP increased Nrf2 expression.

    Peptide
    Davunetide
    Outcome
    IncreaseNrf2 expression
    Study

    ratn: not reported in source

    Chronic hypobaric hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2μg/Kg body weight · intranasalAs given in this study (rat).

    Source sentences

    Summary
    We have also observed a significant increased expression of Nrf2, the master regulator of antioxidant defense system and its downstream targets such as HO-1, GST and SOD1 by NAP supplementation, suggesting activation of Nrf2-mediated antioxidant defense response.
    1 context sentence
    Summary · context
    In the present study, we have investigated the antioxidant and memory protection efficacy of the synthetic NAP peptide (NAPVSIPQ) during long-term chronic hypobaric hypoxia (7, 14, 21 and 28 days, 25,000ft) in rats.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In hypobaric hypoxia-exposed rats, NAP significantly increased HO-1 expression.

    In plain wordsIn rats exposed to hypoxia, NAP increased HO-1 expression.

    Peptide
    Davunetide
    Outcome
    IncreaseHO-1 expression
    Study

    ratn: not reported in source

    Chronic hypobaric hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2μg/Kg body weight · intranasalAs given in this study (rat).

    Source sentences

    Summary
    We have also observed a significant increased expression of Nrf2, the master regulator of antioxidant defense system and its downstream targets such as HO-1, GST and SOD1 by NAP supplementation, suggesting activation of Nrf2-mediated antioxidant defense response.
    1 context sentence
    Summary · context
    In the present study, we have investigated the antioxidant and memory protection efficacy of the synthetic NAP peptide (NAPVSIPQ) during long-term chronic hypobaric hypoxia (7, 14, 21 and 28 days, 25,000ft) in rats.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In hypobaric hypoxia-exposed rats, NAP significantly increased GST expression.

    In plain wordsIn rats exposed to hypoxia, NAP increased GST expression.

    Peptide
    Davunetide
    Outcome
    IncreaseGST expression
    Study

    ratn: not reported in source

    Chronic hypobaric hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2μg/Kg body weight · intranasalAs given in this study (rat).

    Source sentences

    Summary
    We have also observed a significant increased expression of Nrf2, the master regulator of antioxidant defense system and its downstream targets such as HO-1, GST and SOD1 by NAP supplementation, suggesting activation of Nrf2-mediated antioxidant defense response.
    1 context sentence
    Summary · context
    In the present study, we have investigated the antioxidant and memory protection efficacy of the synthetic NAP peptide (NAPVSIPQ) during long-term chronic hypobaric hypoxia (7, 14, 21 and 28 days, 25,000ft) in rats.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In hypobaric hypoxia-exposed rats, NAP significantly increased SOD1 expression.

    In plain wordsIn rats exposed to hypoxia, NAP increased SOD1 expression.

    Peptide
    Davunetide
    Outcome
    IncreaseSOD1 expression
    Study

    ratn: not reported in source

    Chronic hypobaric hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2μg/Kg body weight · intranasalAs given in this study (rat).

    Source sentences

    Summary
    We have also observed a significant increased expression of Nrf2, the master regulator of antioxidant defense system and its downstream targets such as HO-1, GST and SOD1 by NAP supplementation, suggesting activation of Nrf2-mediated antioxidant defense response.
    1 context sentence
    Summary · context
    In the present study, we have investigated the antioxidant and memory protection efficacy of the synthetic NAP peptide (NAPVSIPQ) during long-term chronic hypobaric hypoxia (7, 14, 21 and 28 days, 25,000ft) in rats.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In hypobaric hypoxia-exposed rats, NAP improved memory assessed with the radial arm maze.

    In plain wordsIn rats exposed to hypoxia, NAP improved memory in a maze test.

    Peptide
    Davunetide
    Outcome
    IncreaseRadial arm maze memory
    Study

    ratn: not reported in source

    Chronic hypobaric hypoxia
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2μg/Kg body weight · intranasalAs given in this study (rat).

    Source sentences

    Summary
    In corroboration, our results also demonstrate that NAP supplementation improved the memory function assessed with radial arm maze.
    1 context sentence
    Summary · context
    In the present study, we have investigated the antioxidant and memory protection efficacy of the synthetic NAP peptide (NAPVSIPQ) during long-term chronic hypobaric hypoxia (7, 14, 21 and 28 days, 25,000ft) in rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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