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Study · Animal study (in vivo) · mouse · 2011

13 results

[Effects of thymosin alpha-1 on radiation-induced pneumonitis].

Yu R, Sun Y, Cai Q, Li Y, Zhu G

Zhongguo fei ai za zhi = Chinese journal of lung cancer1 Mar 2011Cited by 1 (Europe PMC)

PMID21426658 (opens in a new tab)PMCIDPMC5999649 (opens in a new tab)DOI10.3779/j.issn.1009-3419.2011.03.02 (opens in a new tab)PepBankPUB-21426658
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Summary

Background and objectiveRadiation-induced lung injure is one of the major factors of limitation in radiotherapy for lung cancer. Whether the use of thymosin and radiotherapy simultaneously would increase the radiation-induced lung injure is unclear. The aim of this study is to evaluate the effects of thymosin alpha-1 on radiation induced pneumonitis in mice.MethodsThree groups of mice, control (C), radiation alone (RT), thymosin alpha-1 plus radiation (T+RT), were entered into the study. The weight and mortality of mice, pleural effusion, quantity of protein and cell count in the bronchoalvealar lavage (BAL) and pulmonary fibrosis score were evaluated as the outcome measures.ResultsThe mortality ratio of the T+RT and RT groups were 3/14, 2/10, respectively. The time of death were all in the 23-24 weeks after radiotherapy. There was no pleural effusion in the T+RT group other than 2/2 occurred in RT group. The quantity of protein, cell number and neutrophil number in the BAL and lung coefficient in mice of T+RT group were remarkably lower than that of RT group, but the BALF macrophages number was remarkably higher than that in RT group in the 8 weeks. The quantity of protein, cell number, neutrophil number and macrophages number in the BAL, lung coefficient, the scores of lung fibrosis in mice of T+RT group were significantly lower than that of RT group in the 24 weeks. All test data were lowest in mice of C group. And there was no obvious pulmonary fibrosis in the mice of C group.ConclusionsThymosin alpha-1 could relieve radiation-induced acute and late pulmonary injuries.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice given radiation, mortality was 3/14 with thymosin alpha‑1 plus radiation and 2/10 with radiation alone.

    In plain wordsIn mice given radiation, 3 of 14 died with thymosin alpha‑1 and 2 of 10 died with radiation alone.

    Peptide
    Thymosin alpha-1
    Outcome
    Direction not reportedMortality
    Study

    micen: not reported in source

    Comparator
    Radiation alone
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mortality ratio of the T+RT and RT groups were 3/14, 2/10, respectively.
    1 context sentence
    Summary · context
    Three groups of mice, control (C), radiation alone (RT), thymosin alpha-1 plus radiation (T+RT), were entered into the study.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice given radiation, thymosin alpha‑1 plus radiation caused no pleural effusion, while 2/2 occurred with radiation alone.

    In plain wordsIn mice given radiation, no pleural effusion occurred with thymosin alpha‑1, while it occurred with radiation alone.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreasePleural effusion
    Study

    micen: not reported in source

    Comparator
    Radiation alone
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There was no pleural effusion in the T+RT group other than 2/2 occurred in RT group.
    1 context sentence
    Summary · context
    Three groups of mice, control (C), radiation alone (RT), thymosin alpha-1 plus radiation (T+RT), were entered into the study.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice given radiation, thymosin alpha‑1 lowered the quantity of protein in bronchoalveolar lavage at 8 weeks versus radiation alone.

    In plain wordsIn mice given radiation, thymosin alpha‑1 lowered lung lavage protein at 8 weeks compared with radiation alone.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseBAL protein at 8 weeks
    Study

    micen: not reported in source

    Comparator
    Radiation alone
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The quantity of protein, cell number and neutrophil number in the BAL and lung coefficient in mice of T+RT group were remarkably lower than that of RT group, but the BALF macrophages number was remarkably higher than that in RT group in the 8 weeks.
    1 context sentence
    Summary · context
    Three groups of mice, control (C), radiation alone (RT), thymosin alpha-1 plus radiation (T+RT), were entered into the study.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice given radiation, thymosin alpha‑1 lowered the cell number in bronchoalveolar lavage at 8 weeks versus radiation alone.

    In plain wordsIn mice given radiation, thymosin alpha‑1 lowered lung lavage cell counts at 8 weeks compared with radiation alone.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseBAL cell number at 8 weeks
    Study

    micen: not reported in source

    Comparator
    Radiation alone
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The quantity of protein, cell number and neutrophil number in the BAL and lung coefficient in mice of T+RT group were remarkably lower than that of RT group, but the BALF macrophages number was remarkably higher than that in RT group in the 8 weeks.
    1 context sentence
    Summary · context
    Three groups of mice, control (C), radiation alone (RT), thymosin alpha-1 plus radiation (T+RT), were entered into the study.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice given radiation, thymosin alpha‑1 lowered the neutrophil number in bronchoalveolar lavage at 8 weeks versus radiation alone.

    In plain wordsIn mice given radiation, thymosin alpha‑1 lowered lung lavage neutrophils at 8 weeks compared with radiation alone.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseBAL neutrophil number at 8 weeks
    Study

    micen: not reported in source

    Comparator
    Radiation alone
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The quantity of protein, cell number and neutrophil number in the BAL and lung coefficient in mice of T+RT group were remarkably lower than that of RT group, but the BALF macrophages number was remarkably higher than that in RT group in the 8 weeks.
    1 context sentence
    Summary · context
    Three groups of mice, control (C), radiation alone (RT), thymosin alpha-1 plus radiation (T+RT), were entered into the study.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice given radiation, thymosin alpha‑1 lowered the lung coefficient at 8 weeks versus radiation alone.

    In plain wordsIn mice given radiation, thymosin alpha‑1 lowered the lung coefficient at 8 weeks compared with radiation alone.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseLung coefficient at 8 weeks
    Study

    micen: not reported in source

    Comparator
    Radiation alone
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The quantity of protein, cell number and neutrophil number in the BAL and lung coefficient in mice of T+RT group were remarkably lower than that of RT group, but the BALF macrophages number was remarkably higher than that in RT group in the 8 weeks.
    1 context sentence
    Summary · context
    Three groups of mice, control (C), radiation alone (RT), thymosin alpha-1 plus radiation (T+RT), were entered into the study.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice given radiation, thymosin alpha‑1 raised the macrophage number in bronchoalveolar lavage at 8 weeks versus radiation alone.

    In plain wordsIn mice given radiation, thymosin alpha‑1 raised lung lavage macrophages at 8 weeks compared with radiation alone.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseBAL macrophage number at 8 weeks
    Study

    micen: not reported in source

    Comparator
    Radiation alone
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The quantity of protein, cell number and neutrophil number in the BAL and lung coefficient in mice of T+RT group were remarkably lower than that of RT group, but the BALF macrophages number was remarkably higher than that in RT group in the 8 weeks.
    1 context sentence
    Summary · context
    Three groups of mice, control (C), radiation alone (RT), thymosin alpha-1 plus radiation (T+RT), were entered into the study.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice given radiation, thymosin alpha‑1 lowered the quantity of protein in bronchoalveolar lavage at 24 weeks versus radiation alone.

    In plain wordsIn mice given radiation, thymosin alpha‑1 lowered lung lavage protein at 24 weeks compared with radiation alone.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseBAL protein at 24 weeks
    Study

    micen: not reported in source

    Comparator
    Radiation alone
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The quantity of protein, cell number, neutrophil number and macrophages number in the BAL, lung coefficient, the scores of lung fibrosis in mice of T+RT group were significantly lower than that of RT group in the 24 weeks.
    1 context sentence
    Summary · context
    Three groups of mice, control (C), radiation alone (RT), thymosin alpha-1 plus radiation (T+RT), were entered into the study.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice given radiation, thymosin alpha‑1 lowered the cell number in bronchoalveolar lavage at 24 weeks versus radiation alone.

    In plain wordsIn mice given radiation, thymosin alpha‑1 lowered lung lavage cell counts at 24 weeks compared with radiation alone.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseBAL cell number at 24 weeks
    Study

    micen: not reported in source

    Comparator
    Radiation alone
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The quantity of protein, cell number, neutrophil number and macrophages number in the BAL, lung coefficient, the scores of lung fibrosis in mice of T+RT group were significantly lower than that of RT group in the 24 weeks.
    1 context sentence
    Summary · context
    Three groups of mice, control (C), radiation alone (RT), thymosin alpha-1 plus radiation (T+RT), were entered into the study.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In mice given radiation, thymosin alpha‑1 lowered the neutrophil number in bronchoalveolar lavage at 24 weeks versus radiation alone.

    In plain wordsIn mice given radiation, thymosin alpha‑1 lowered lung lavage neutrophils at 24 weeks compared with radiation alone.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseBAL neutrophil number at 24 weeks
    Study

    micen: not reported in source

    Comparator
    Radiation alone
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The quantity of protein, cell number, neutrophil number and macrophages number in the BAL, lung coefficient, the scores of lung fibrosis in mice of T+RT group were significantly lower than that of RT group in the 24 weeks.
    1 context sentence
    Summary · context
    Three groups of mice, control (C), radiation alone (RT), thymosin alpha-1 plus radiation (T+RT), were entered into the study.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In mice given radiation, thymosin alpha‑1 lowered the macrophage number in bronchoalveolar lavage at 24 weeks versus radiation alone.

    In plain wordsIn mice given radiation, thymosin alpha‑1 lowered lung lavage macrophages at 24 weeks compared with radiation alone.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseBAL macrophage number at 24 weeks
    Study

    micen: not reported in source

    Comparator
    Radiation alone
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The quantity of protein, cell number, neutrophil number and macrophages number in the BAL, lung coefficient, the scores of lung fibrosis in mice of T+RT group were significantly lower than that of RT group in the 24 weeks.
    1 context sentence
    Summary · context
    Three groups of mice, control (C), radiation alone (RT), thymosin alpha-1 plus radiation (T+RT), were entered into the study.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In mice given radiation, thymosin alpha‑1 lowered the lung coefficient at 24 weeks versus radiation alone.

    In plain wordsIn mice given radiation, thymosin alpha‑1 lowered the lung coefficient at 24 weeks compared with radiation alone.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseLung coefficient at 24 weeks
    Study

    micen: not reported in source

    Comparator
    Radiation alone
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The quantity of protein, cell number, neutrophil number and macrophages number in the BAL, lung coefficient, the scores of lung fibrosis in mice of T+RT group were significantly lower than that of RT group in the 24 weeks.
    1 context sentence
    Summary · context
    Three groups of mice, control (C), radiation alone (RT), thymosin alpha-1 plus radiation (T+RT), were entered into the study.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In mice given radiation, thymosin alpha‑1 lowered the lung fibrosis score at 24 weeks versus radiation alone.

    In plain wordsIn mice given radiation, thymosin alpha‑1 lowered lung fibrosis scores at 24 weeks compared with radiation alone.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseLung fibrosis score at 24 weeks
    Study

    micen: not reported in source

    Comparator
    Radiation alone
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The quantity of protein, cell number, neutrophil number and macrophages number in the BAL, lung coefficient, the scores of lung fibrosis in mice of T+RT group were significantly lower than that of RT group in the 24 weeks.
    1 context sentence
    Summary · context
    Three groups of mice, control (C), radiation alone (RT), thymosin alpha-1 plus radiation (T+RT), were entered into the study.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

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Terms as the source lists them.

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