Effects of nootropics on the EEG in conscious rats and their modification by glutamatergic inhibitors.

Vorobyov V, Kaptsov V, Kovalev G, Sengpiel F

Brain research bulletin15 Mar 2011Cited by 7 (Europe PMC)

PMID21414388DOI10.1016/j.brainresbull.2011.02.011PepBankPUB-21414388

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats, Noopept increased alpha/beta1 EEG activity in all brain areas, with a 30-min latency and 40-min duration.
In plain wordsIn rats, Noopept increased alpha/beta1 brain electrical activity in all brain areas.
Peptide
Noopept (omberacetam)
Outcome
IncreaseAlpha/beta1 EEG activity
Study
ratsn: not reported in source
Conscious non-narcotized rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.2mg/kg · subcutaneousAs given in this study (rats).
Measurements
Latency
30 min
Noopept EEG effect
Effect duration
40 min
Noopept EEG effect
Source sentences
Summary
Noopept increased alpha/beta1 activity, with 30-min latency and 40-min duration in all brain areas.
1 context sentence(design, population, supporting numbers)
Summary · context
the frequency spectra of cortical and hippocampal electroencephalogram (EEG) were analyzed in non-narcotized rats subcutaneously injected repeatedly with Piracetam (400mg/kg) or its analogue, Noopept (0.2mg/kg),
Report a problemFND-2141438801
02AnimalAnimal study (in vivo)Mechanism
In rats, increased beta2 activity replaced Noopept's alpha/beta1 EEG effect after the eighth injection.
In plain wordsIn rats, Noopept increased beta2 brain activity instead of alpha/beta1 activity after the eighth injection.
Peptide
Noopept (omberacetam)
Outcome
MixedEEG activity after eighth injection
Study
ratsn: not reported in source
Conscious non-narcotized rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.2mg/kg · subcutaneousAs given in this study (rats).
Source sentences
Summary
The effect of Noopept in the alpha/beta1 ranges was replaced by increased beta2 activity after the eighth injection, while no effects were observed after the ninth one.
1 context sentence(design, population, supporting numbers)
Summary · context
the frequency spectra of cortical and hippocampal electroencephalogram (EEG) were analyzed in non-narcotized rats subcutaneously injected repeatedly with Piracetam (400mg/kg) or its analogue, Noopept (0.2mg/kg),
Report a problemFND-2141438804
03AnimalAnimal study (in vivo)Mechanism
In rats, Noopept showed no EEG effects after the ninth injection.
In plain wordsIn rats, Noopept showed no effect on brain electrical activity after the ninth injection.
Peptide
Noopept (omberacetam)
Outcome
No significant changeEEG activity after ninth injection
Study
ratsn: not reported in source
Conscious non-narcotized rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.2mg/kg · subcutaneousAs given in this study (rats).
Source sentences
Summary
The effect of Noopept in the alpha/beta1 ranges was replaced by increased beta2 activity after the eighth injection, while no effects were observed after the ninth one.
1 context sentence(design, population, supporting numbers)
Summary · context
the frequency spectra of cortical and hippocampal electroencephalogram (EEG) were analyzed in non-narcotized rats subcutaneously injected repeatedly with Piracetam (400mg/kg) or its analogue, Noopept (0.2mg/kg),
Report a problemFND-2141438805

Studies that did not test the peptide alone3

In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Noopept (omberacetam).

04AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Mechanism
In rats, CPP pretreatment reduced Noopept's cortical EEG effects.
In plain wordsIn rats, CPP pretreatment reduced Noopept's effects on cortical electrical activity compared with Noopept alone.
Peptide
Noopept (omberacetam)
Outcome
DecreaseCortical EEG response with CPP
Study
ratsn: not reported in source
Conscious non-narcotized rats
Comparator
Noopept without CPP pretreatment
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
CPP pretreatment eliminated Piracetam EEG effects; reduced Noopept effects in the cortex and completely suppressed them in the hippocampus.
1 context sentence(design, population, supporting numbers)
Summary · context
the frequency spectra of cortical and hippocampal electroencephalogram (EEG) were analyzed in non-narcotized rats subcutaneously injected repeatedly with Piracetam (400mg/kg) or its analogue, Noopept (0.2mg/kg),
In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).
Report a problemFND-2141438802
05AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Mechanism
In rats, CPP pretreatment completely suppressed Noopept's hippocampal EEG effects.
In plain wordsIn rats, CPP pretreatment blocked Noopept's effects on hippocampal electrical activity compared with Noopept alone.
Peptide
Noopept (omberacetam)
Outcome
DecreaseHippocampal EEG response with CPP
Study
ratsn: not reported in source
Conscious non-narcotized rats
Comparator
Noopept without CPP pretreatment
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
CPP pretreatment eliminated Piracetam EEG effects; reduced Noopept effects in the cortex and completely suppressed them in the hippocampus.
1 context sentence(design, population, supporting numbers)
Summary · context
the frequency spectra of cortical and hippocampal electroencephalogram (EEG) were analyzed in non-narcotized rats subcutaneously injected repeatedly with Piracetam (400mg/kg) or its analogue, Noopept (0.2mg/kg),
In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).
Report a problemFND-2141438803
06AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Mechanism
In rats, GDEE pretreatment restored Noopept's beta2 EEG effect.
In plain wordsIn rats, GDEE pretreatment restored Noopept's beta2 brain activity effect compared with repeated Noopept alone.
Peptide
Noopept (omberacetam)
Outcome
IncreaseBeta2 EEG response with GDEE
Study
ratsn: not reported in source
Conscious non-narcotized rats
Comparator
Repeated Noopept without GDEE pretreatment
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
GDEE pretreatment restored the effect of Noopept in the beta2 frequency range.
1 context sentence(design, population, supporting numbers)
Summary · context
the frequency spectra of cortical and hippocampal electroencephalogram (EEG) were analyzed in non-narcotized rats subcutaneously injected repeatedly with Piracetam (400mg/kg) or its analogue, Noopept (0.2mg/kg),
In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).
Report a problemFND-2141438806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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