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Study · In vitro (cells) · 2011

3 results

The erythropoietin analogue ARA290 modulates the innate immune response and reduces Escherichia coli invasion into urothelial cells.

Polgárová K, Lüthje P, Cerami A, Brauner A

FEMS immunology and medical microbiology11 Apr 2011Cited by 8 (Europe PMC)

PMID21410562 (opens in a new tab)DOI10.1111/j.1574-695x.2011.00801.x (opens in a new tab)PepBankPUB-21410562
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In bladder epithelial cell lines, primary cells and THP-1 cells, ARA290 further enhanced the bacteria-induced expression of the erythropoietin receptor.

    In plain wordsIn lab cells, ARA290 further raised the level of the erythropoietin receptor that bacteria had already increased.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseErythropoietin receptor expression
    Study

    n: not reported in source

    Bladder epithelial cell lines, primary bladder cells and THP-1 monocytic cells
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Expression of the erythropoietin receptor was increased by bacterial stimuli and further enhanced by ARA290 in bladder epithelial cell lines and primary cells as well as in the monocytic cell line THP-1.
    1 context sentence
    Summary · context
    Here, we investigated the nonerythropoietic erythropoietin analogue ARA290 for potential properties to modulate uroepithelial infection by E. coli in a cell culture model.
  2. 02LabIn vitro (cells)Activity measurement

    In the cell culture model, ARA290 induced a strong initial but temporarily limited interleukin-8 response.

    In plain wordsIn lab cells, ARA290 caused a strong but short-lived rise in the immune signal interleukin-8.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseInterleukin-8 induction
    Study

    n: not reported in source

    Cell culture model of uroepithelial E. coli infection
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Stimulation with ARA290 promoted an immune response, inducing a strong initial, but temporarily limited interleukin-8 induction.
    1 context sentence
    Summary · context
    Here, we investigated the nonerythropoietic erythropoietin analogue ARA290 for potential properties to modulate uroepithelial infection by E. coli in a cell culture model.
  3. 03LabIn vitro (cells)Activity measurement

    In bladder epithelial cells, costimulation with ARA290 significantly reduced invasion by E. coli.

    In plain wordsIn lab cells, ARA290 reduced how many E. coli bacteria entered bladder cells.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseE. coli invasion of bladder epithelial cells
    Study

    n: not reported in source

    Cell culture model of uroepithelial E. coli infection
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, the invasion of bladder epithelial cells by E. coli was significantly reduced in cells costimulated with ARA290.
    1 context sentence
    Summary · context
    Here, we investigated the nonerythropoietic erythropoietin analogue ARA290 for potential properties to modulate uroepithelial infection by E. coli in a cell culture model.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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