[On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines].

Ostrovskaia RU, Vakhitova IuV, Salimgareeva MKh, Iamidanov RS, Sadovnikov SV, Kapitsa IG, Seredenin SB

Eksperimental'naia i klinicheskaia farmakologiia1 Dec 2010Cited by 2 (Europe PMC)

PMID21395007PepBankPUB-21395007

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats, chronic Noopept administration decreased hippocampal SAPK/JNK 46/54 activity.
In plain wordsIn rats, prolonged Noopept treatment reduced hippocampal stress kinase activity called SAPK/JNK.
Peptide
Noopept (omberacetam)
Outcome
DecreaseHippocampal SAPK/JNK 46/54 activity
Study
ratsn: not reported in source
Rat brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.5 mg/day · intraperitoneal · 28 daysAs given in this study (rats).
Source sentences
Summary
Under conditions of chronic administration (28 days, 0.5 mg/day, i.p.), noopept decreased the activity of stress-induced kinases (SAPK/JNK 46/54 and pERK1/2) in rat hippocampus and increases the level of mRNA of the BDNF gene in both hypothalamus and hippocampus.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111)--a drug combining the nootrope and neuroprotector properties--on the activity of mitogen-activated protein kinases (MAPKs) and the level of NGF and BDNF gene and protein expression in the frontal cortex, hippocampus, and…
Report a problemFND-2139500701
02AnimalAnimal study (in vivo)Mechanism
In rats, chronic Noopept administration decreased hippocampal pERK1/2 activity.
In plain wordsIn rats, prolonged Noopept treatment reduced hippocampal kinase activity called pERK.
Peptide
Noopept (omberacetam)
Outcome
DecreaseHippocampal pERK1/2 activity
Study
ratsn: not reported in source
Rat brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.5 mg/day · intraperitoneal · 28 daysAs given in this study (rats).
Source sentences
Summary
Under conditions of chronic administration (28 days, 0.5 mg/day, i.p.), noopept decreased the activity of stress-induced kinases (SAPK/JNK 46/54 and pERK1/2) in rat hippocampus and increases the level of mRNA of the BDNF gene in both hypothalamus and hippocampus.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111)--a drug combining the nootrope and neuroprotector properties--on the activity of mitogen-activated protein kinases (MAPKs) and the level of NGF and BDNF gene and protein expression in the frontal cortex, hippocampus, and…
Report a problemFND-2139500702
03AnimalAnimal study (in vivo)Mechanism
In rats, chronic Noopept administration increased hypothalamic BDNF mRNA.
In plain wordsIn rats, prolonged Noopept treatment increased BDNF gene messages in the hypothalamus.
Peptide
Noopept (omberacetam)
Outcome
IncreaseHypothalamic BDNF mRNA
Study
ratsn: not reported in source
Rat brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.5 mg/day · intraperitoneal · 28 daysAs given in this study (rats).
Source sentences
Summary
Under conditions of chronic administration (28 days, 0.5 mg/day, i.p.), noopept decreased the activity of stress-induced kinases (SAPK/JNK 46/54 and pERK1/2) in rat hippocampus and increases the level of mRNA of the BDNF gene in both hypothalamus and hippocampus.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111)--a drug combining the nootrope and neuroprotector properties--on the activity of mitogen-activated protein kinases (MAPKs) and the level of NGF and BDNF gene and protein expression in the frontal cortex, hippocampus, and…
Report a problemFND-2139500703
04AnimalAnimal study (in vivo)Mechanism
In rats, chronic Noopept administration increased hippocampal BDNF mRNA.
In plain wordsIn rats, prolonged Noopept treatment increased BDNF gene messages in the hippocampus.
Peptide
Noopept (omberacetam)
Outcome
IncreaseHippocampal BDNF mRNA
Study
ratsn: not reported in source
Rat brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.5 mg/day · intraperitoneal · 28 daysAs given in this study (rats).
Source sentences
Summary
Under conditions of chronic administration (28 days, 0.5 mg/day, i.p.), noopept decreased the activity of stress-induced kinases (SAPK/JNK 46/54 and pERK1/2) in rat hippocampus and increases the level of mRNA of the BDNF gene in both hypothalamus and hippocampus.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111)--a drug combining the nootrope and neuroprotector properties--on the activity of mitogen-activated protein kinases (MAPKs) and the level of NGF and BDNF gene and protein expression in the frontal cortex, hippocampus, and…
Report a problemFND-2139500704
05AnimalAnimal study (in vivo)Mechanism
In rats, chronic Noopept administration somewhat increased hypothalamic BDNF protein content.
In plain wordsIn rats, prolonged Noopept treatment somewhat increased BDNF protein in the hypothalamus.
Peptide
Noopept (omberacetam)
Outcome
IncreaseHypothalamic BDNF protein
Study
ratsn: not reported in source
Rat brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.5 mg/day · intraperitoneal · 28 daysAs given in this study (rats).
Source sentences
Summary
The content of BDNF protein in the hypothalamus was also somewhat increased.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111)--a drug combining the nootrope and neuroprotector properties--on the activity of mitogen-activated protein kinases (MAPKs) and the level of NGF and BDNF gene and protein expression in the frontal cortex, hippocampus, and…
Report a problemFND-2139500705

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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