Vasoactive intestinal polypeptide requires parallel changes in adenylate cyclase and phospholipase C to entrain circadian rhythms to a predictable phase.

An S, Irwin RP, Allen CN, Tsai C, Herzog ED

Journal of neurophysiology9 Mar 2011Cited by 66 (Europe PMC)

PMID21389307PMCIDPMC3094187DOI10.1152/jn.00966.2010PepBankPUB-21389307

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In suprachiasmatic nucleus (SCN) preparations, single applications of VIP reset PER2 rhythms in a time- and dose-dependent manner that differed from light.
In plain wordsIn lab tests on the brain's body clock, one VIP dose shifted the clock rhythm, and the shift depended on timing and dose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicablePER2 rhythm reset by single VIP application
Study
n: not reported in source
Outcome group
Circadian rhythm · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
We found that single applications of VIP reset PER2 rhythms in a time- and dose-dependent manner that differed from light.
Report a problemFND-2138930701
02LabEx vivo tissueMechanism
In SCN preparations, blocking both adenylate cyclase and phospholipase C together was required to block VIP-induced phase shifts of SCN rhythms.
In plain wordsIn lab tests on the brain's body clock, VIP shifts needed both of two signaling pathways to be blocked before they stopped.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableSignaling pathways needed for VIP-induced phase shifts
Study
n: not reported in source
Outcome group
Circadian rhythm · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Unlike VIP-mediated signaling in other cell types, simultaneous antagonism of adenylate cyclase and phospholipase C activities was required to block the VIP-induced phase shifts of SCN rhythms.
Report a problemFND-2138930702
03LabEx vivo tissueMechanism
In SCN neurons, VIP rapidly increased intracellular cAMP in most neurons.
In plain wordsIn lab tests on brain clock cells, VIP quickly raised cAMP, a cell signal, in most cells.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseIntracellular cAMP in SCN neurons
Study
n: not reported in source
Outcome group
Circadian rhythm · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Consistent with this, VIP rapidly increased intracellular cAMP in most SCN neurons.
Report a problemFND-2138930703
04LabEx vivo tissueMechanism
In SCN preparations, daily VIP treatment entrained PER2 rhythms to a predicted phase angle within several days, depending on VIP concentration and the interval between applications.
In plain wordsIn lab tests on the brain's body clock, daily VIP set the clock rhythm to a predicted phase within days, depending on dose and interval.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableEntrainment of PER2 rhythms by daily VIP
Study
n: not reported in source
Outcome group
Circadian rhythm · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Critically, daily VIP treatment entrained PER2 rhythms to a predicted phase angle within several days, depending on the concentration of VIP and the interval between VIP applications.
Report a problemFND-2138930704

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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