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Study · Animal study (in vivo) · mouse · 2011

11 results

Neonatal thymulin gene therapy in nude mice: Effects on the morphology of the pituitary corticotrope population.

Martines E, Reggiani PC, Schwerdt JI, Goya RG, Cónsole G

Histology and histopathology1 Apr 2011Cited by 2 (Europe PMC)

PMID21360440 (opens in a new tab)DOI10.14670/hh-26.471 (opens in a new tab)PepBankPUB-21360440
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In adult athymic mice, thymulin administration tended to reverse the slight increase in hypothalamic CRH content.

    In plain wordsIn adult athymic mice, thymulin tended to reverse the slight increase in hypothalamic CRH content.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseHypothalamic CRH content after thymulin
    Study

    mousen: not reported in source

    Adult athymic mice
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymulin administration to adult mice tended to reverse these changes.
    2 context sentences
    Summary · context
    In these mutants hypothalamic CRH content was slightly increased, whereas adrenal corticosterone tended to be lower.
    Summary · context
    The effect of thymulin administration to adult nudes on their hypothalamic content of corticotropin-releasing hormone (CRH) and the adrenal content of corticosterone was also determined.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In adult athymic mice, thymulin administration tended to reverse the lower adrenal corticosterone content.

    In plain wordsIn adult athymic mice, thymulin tended to reverse the lower adrenal corticosterone content.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseAdrenal corticosterone content after thymulin
    Study

    mousen: not reported in source

    Adult athymic mice
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymulin administration to adult mice tended to reverse these changes.
    2 context sentences
    Summary · context
    In these mutants hypothalamic CRH content was slightly increased, whereas adrenal corticosterone tended to be lower.
    Summary · context
    The effect of thymulin administration to adult nudes on their hypothalamic content of corticotropin-releasing hormone (CRH) and the adrenal content of corticosterone was also determined.

Studies that did not test the peptide alone9

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 03AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In athymic mice, neonatal thymulin gene therapy restored serum thymulin levels.

    In plain wordsIn athymic mice, thymulin gene therapy restored blood thymulin levels.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicableSerum thymulin after gene therapy
    Study

    mousen: not reported in source

    Athymic mice
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Neonatal thymulin gene therapy in the athymic mice restored their serum thymulin levels and increased corticotrope CD, VD and CS in both control and athymic mice.
    1 context sentence
    Summary · context
    We used an adenoviral vector expressing a synthetic gene for the thymic peptide thymulin (metFTS) termed RAd-FTS. On postnatal day 1 or 2, heterozygous (nu/+) and homozygous (nu/nu) pups of both sexes received a single bilateral i.m. injection of RAd-FTS or RAd-GFP, a control vector.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 04AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In control and athymic mice, neonatal thymulin gene therapy increased corticotrope cell density versus the control vector.

    In plain wordsIn control and athymic mice, thymulin gene therapy increased corticotropin cell density compared with the control vector.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseCorticotrope cell density after gene therapy
    Study

    mousen: not reported in source

    Control and athymic mice
    Comparator
    RAd-GFP control vector
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Neonatal thymulin gene therapy in the athymic mice restored their serum thymulin levels and increased corticotrope CD, VD and CS in both control and athymic mice.
    1 context sentence
    Summary · context
    On postnatal day 1 or 2, heterozygous (nu/+) and homozygous (nu/nu) pups of both sexes received a single bilateral i.m. injection of RAd-FTS or RAd-GFP, a control vector.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  3. 05AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In control and athymic mice, neonatal thymulin gene therapy increased corticotrope volume density versus the control vector.

    In plain wordsIn control and athymic mice, thymulin gene therapy increased corticotropin cell volume density compared with the control vector.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseCorticotrope volume density after gene therapy
    Study

    mousen: not reported in source

    Control and athymic mice
    Comparator
    RAd-GFP control vector
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Neonatal thymulin gene therapy in the athymic mice restored their serum thymulin levels and increased corticotrope CD, VD and CS in both control and athymic mice.
    1 context sentence
    Summary · context
    On postnatal day 1 or 2, heterozygous (nu/+) and homozygous (nu/nu) pups of both sexes received a single bilateral i.m. injection of RAd-FTS or RAd-GFP, a control vector.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  4. 06AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In control and athymic mice, neonatal thymulin gene therapy increased corticotrope cell surface versus the control vector.

    In plain wordsIn control and athymic mice, thymulin gene therapy increased corticotropin cell surface compared with the control vector.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseCorticotrope cell surface after gene therapy
    Study

    mousen: not reported in source

    Control and athymic mice
    Comparator
    RAd-GFP control vector
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Neonatal thymulin gene therapy in the athymic mice restored their serum thymulin levels and increased corticotrope CD, VD and CS in both control and athymic mice.
    1 context sentence
    Summary · context
    On postnatal day 1 or 2, heterozygous (nu/+) and homozygous (nu/nu) pups of both sexes received a single bilateral i.m. injection of RAd-FTS or RAd-GFP, a control vector.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  5. 07AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    Athymic mice showed only a marginal reduction in corticotrope cell density compared with controls.

    In plain wordsIn athymic mice, corticotropin cell density was only marginally lower than in controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseCorticotrope cell density in athymia
    Study

    mousen: not reported in source

    Athymic mice
    Comparator
    Control mice
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Athymic mice showed only a marginal reduction in corticotrope CD, VD and CS.
    1 context sentence
    Summary · context
    In the present study we assessed the impact of athymia and the effect of neonatal thymulin gene therapy on the corticotropic cell population in nude mice.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  6. 08AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    Athymic mice showed only a marginal reduction in corticotrope volume density compared with controls.

    In plain wordsIn athymic mice, corticotropin cell volume density was only marginally lower than in controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseCorticotrope volume density in athymia
    Study

    mousen: not reported in source

    Athymic mice
    Comparator
    Control mice
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Athymic mice showed only a marginal reduction in corticotrope CD, VD and CS.
    1 context sentence
    Summary · context
    In the present study we assessed the impact of athymia and the effect of neonatal thymulin gene therapy on the corticotropic cell population in nude mice.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  7. 09AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    Athymic mice showed only a marginal reduction in corticotrope cell surface compared with controls.

    In plain wordsIn athymic mice, corticotropin cell surface was only marginally lower than in controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseCorticotrope cell surface in athymia
    Study

    mousen: not reported in source

    Athymic mice
    Comparator
    Control mice
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Athymic mice showed only a marginal reduction in corticotrope CD, VD and CS.
    1 context sentence
    Summary · context
    In the present study we assessed the impact of athymia and the effect of neonatal thymulin gene therapy on the corticotropic cell population in nude mice.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  8. 10AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    Athymic mice showed slightly increased hypothalamic CRH content compared with controls.

    In plain wordsIn athymic mice, hypothalamic CRH content was slightly higher than in controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseHypothalamic CRH content in athymia
    Study

    mousen: not reported in source

    Athymic mice
    Comparator
    Control mice
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    In these mutants hypothalamic CRH content was slightly increased, whereas adrenal corticosterone tended to be lower.
    1 context sentence
    Summary · context
    Athymic mice showed only a marginal reduction in corticotrope CD, VD and CS.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  9. 11AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    Athymic mice tended to have lower adrenal corticosterone content compared with controls.

    In plain wordsIn athymic mice, adrenal corticosterone content tended to be lower than in controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseAdrenal corticosterone content in athymia
    Study

    mousen: not reported in source

    Athymic mice
    Comparator
    Control mice
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    In these mutants hypothalamic CRH content was slightly increased, whereas adrenal corticosterone tended to be lower.
    1 context sentence
    Summary · context
    Athymic mice showed only a marginal reduction in corticotrope CD, VD and CS.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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