Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages.

Kandalla PK, Goldspink G, Butler-Browne G, Mouly V

Mechanisms of ageing and development25 Feb 2011Cited by 63 (Europe PMC)

PMID21354439DOI10.1016/j.mad.2011.02.007PepBankPUB-21354439

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In primary human satellite cells from neonatal and young adult donors, MGF-E peptide significantly increased the proliferative life span.
In plain wordsIn human muscle cells from newborn and young adult donors, the MGF E peptide extended how long cells could multiply.
Peptide
MGF / PEG-MGF
Outcome
IncreaseProliferative life span of satellite cells (neonatal and young adult)
Study
humann: not reported in source
Primary human satellite cell cultures
Outcome group
Aging markers · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
We found that MGF-E peptide significantly increases the proliferative life span and delays senescence of satellite cells isolated from neonatal and young adult but not from old adult muscle, hypertrophy associated with a significant decrease in the percentage of reserve cells was observed in all cultures.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the effects of the MGF-24aa-E peptide on proliferation and differentiation of primary human muscle cell cultures isolated from healthy subjects of different ages.
Report a problemFND-2135443901
02LabIn vitro (cells)Efficacy outcome
In primary human satellite cells from neonatal and young adult donors, MGF-E peptide delayed senescence.
In plain wordsIn human muscle cells from newborn and young adult donors, the MGF E peptide delayed cell ageing.
Peptide
MGF / PEG-MGF
Outcome
DecreaseSenescence of satellite cells (neonatal and young adult)
Study
humann: not reported in source
Primary human satellite cell cultures
Outcome group
Aging markers · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
We found that MGF-E peptide significantly increases the proliferative life span and delays senescence of satellite cells isolated from neonatal and young adult but not from old adult muscle, hypertrophy associated with a significant decrease in the percentage of reserve cells was observed in all cultures.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the effects of the MGF-24aa-E peptide on proliferation and differentiation of primary human muscle cell cultures isolated from healthy subjects of different ages.
Report a problemFND-2135443902
03LabIn vitro (cells)Efficacy outcome
In primary human satellite cells from old adult donors, MGF-E peptide did not increase the proliferative life span or delay senescence.
In plain wordsIn human muscle cells from old adult donors, the MGF E peptide did not extend cell life span or delay cell ageing.
Peptide
MGF / PEG-MGF
Outcome
No significant changeProliferative life span and senescence of satellite cells (old adult)
Study
humann: not reported in source
Primary human satellite cell cultures
Outcome group
Aging markers · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
We found that MGF-E peptide significantly increases the proliferative life span and delays senescence of satellite cells isolated from neonatal and young adult but not from old adult muscle, hypertrophy associated with a significant decrease in the percentage of reserve cells was observed in all cultures.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the effects of the MGF-24aa-E peptide on proliferation and differentiation of primary human muscle cell cultures isolated from healthy subjects of different ages.
Report a problemFND-2135443903
04LabIn vitro (cells)Efficacy outcome
In primary human muscle cell cultures of all ages, MGF-E peptide was associated with hypertrophy.
In plain wordsIn human muscle cell cultures of all ages, the MGF E peptide was linked to larger muscle cells.
Peptide
MGF / PEG-MGF
Outcome
IncreaseHypertrophy of cultures
Study
humann: not reported in source
Primary human satellite cell cultures
Outcome group
Aging markers · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
hypertrophy associated with a significant decrease in the percentage of reserve cells was observed in all cultures.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the effects of the MGF-24aa-E peptide on proliferation and differentiation of primary human muscle cell cultures isolated from healthy subjects of different ages.
Report a problemFND-2135443904
05LabIn vitro (cells)Efficacy outcome
In primary human muscle cell cultures of all ages, MGF-E peptide was associated with a significant decrease in the percentage of reserve cells.
In plain wordsIn human muscle cell cultures of all ages, the MGF E peptide was linked to fewer reserve cells.
Peptide
MGF / PEG-MGF
Outcome
DecreasePercentage of reserve cells
Study
humann: not reported in source
Primary human satellite cell cultures
Outcome group
Aging markers · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
hypertrophy associated with a significant decrease in the percentage of reserve cells was observed in all cultures.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the effects of the MGF-24aa-E peptide on proliferation and differentiation of primary human muscle cell cultures isolated from healthy subjects of different ages.
Report a problemFND-2135443905
06LabIn vitro (cells)Efficacy outcome
In primary human muscle cell cultures from donors of different ages, MGF-E peptide increased fusion potential.
In plain wordsIn human muscle cell cultures from donors of different ages, the MGF E peptide raised the ability of cells to fuse.
Peptide
MGF / PEG-MGF
Outcome
IncreaseFusion potential of satellite cells
Study
humann: not reported in source
Primary human satellite cell cultures
Outcome group
Aging markers · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Title
induces an increase in their fusion potential at different ages
Report a problemFND-2135443906

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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