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Study · Measured the body's own peptide · 2011

5 results

Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance.

Zhang G, Bai H, Zhang H, Dean C, Wu Q, Li J, Guariglia S, Meng Q, Cai D

Neuron1 Feb 2011Cited by 183 (Europe PMC)

PMID21315262 (opens in a new tab)PMCIDPMC4353647 (opens in a new tab)DOI10.1016/j.neuron.2010.12.036 (opens in a new tab)PepBankPUB-21315262
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the hypothalamus, synaptotagmin-4 negatively regulated oxytocin exocytosis.

    In plain wordsIn animal studies, a protein called synaptotagmin-4 held back release of the body's own oxytocin in the hypothalamus.

    Peptide
    Oxytocin
    Outcome
    DecreaseRegulation of oxytocin exocytosis by synaptotagmin-4
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    Synaptotagmin-4 negatively regulates oxytocin exocytosis

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    Dietary obesity was associated with increased vesicle binding of synaptotagmin-4 and enhanced negative regulation of oxytocin release.

    In plain wordsIn animal studies, diet-induced obesity was linked to stronger holding back of the body's own oxytocin release.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin release in dietary obesity
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    dietary obesity is associated with increased vesicle binding of synaptotagmin-4 and thus enhanced negative regulation of oxytocin release.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome

    In mice, overexpressing synaptotagmin-4 in hypothalamic oxytocin neurons was obesogenic.

    In plain wordsIn mice, raising synaptotagmin-4 in oxytocin-producing brain cells promoted obesity.

    Peptide
    Oxytocin
    Outcome
    IncreaseObesity after synaptotagmin-4 overexpression in oxytocin neurons
    Study

    mousen: not reported in source

    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    Overexpressing synaptotagmin-4 in hypothalamic oxytocin neurons and centrally antagonizing oxytocin in mice are similarly obesogenic.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome

    In mice, central antagonism of oxytocin was obesogenic.

    In plain wordsIn mice, blocking oxytocin in the brain promoted obesity.

    Peptide
    Oxytocin
    Outcome
    IncreaseObesity after central oxytocin antagonism
    Study

    mousen: not reported in source

    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    Overexpressing synaptotagmin-4 in hypothalamic oxytocin neurons and centrally antagonizing oxytocin in mice are similarly obesogenic.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome

    Synaptotagmin-4 inhibition prevented dietary obesity by normalizing oxytocin release and energy balance under chronic nutritional excess.

    In plain wordsIn animal studies, blocking synaptotagmin-4 prevented diet-induced obesity and normalized oxytocin release.

    Peptide
    Oxytocin
    Outcome
    DecreaseDietary obesity after synaptotagmin-4 inhibition
    Study

    n: not reported in source

    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    Synaptotagmin-4 inhibition prevents against dietary obesity by normalizing oxytocin release and energy balance under chronic nutritional excess.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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