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Study · Not a test of the peptide alone · 2011

1 result

Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance.

Fang S, Suh JM, Atkins AR, Hong SH, Leblanc M, Nofsinger RR, Yu RT, Downes M, Evans RM

Proceedings of the National Academy of Sciences of the United States of America7 Feb 2011Cited by 47 (Europe PMC)

PMID21300871 (opens in a new tab)PMCIDPMC3044388 (opens in a new tab)DOI10.1073/pnas.1017707108 (opens in a new tab)PepBankPUB-21300871
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    SMRT(mRID1) mice were refractory to the glucose-lowering effects of AICAR.

    In plain wordsIn mice with altered SMRT, AICAR did not lower blood glucose.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeAICAR glucose-lowering response
    Study

    mousen: not reported in source

    SMRT(mRID1) mice
    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    SMRT(mRID1) mice are both insulin-insensitive and refractory to the glucose-lowering effects of TZD and AICAR.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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