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Study · Animal study (in vivo) · rat · 2010

4 results

[Nootropic and analgesic effects of Semax following different routes of administration].

Manchenko DM, Glazova NIu, Levitskaia NG, Andreeva LA, Kamenskiĭ AA, Miasoedov NF

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Oct 2010Cited by 1 (Europe PMC)

PMID21268834 (opens in a new tab)PepBankPUB-21268834
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In white rats, intraperitoneal Semax showed nootropic activity in the passive avoidance acquisition test.

    In plain wordsIn rats, Semax given by injection into the abdomen improved learning in a passive avoidance test.

    Peptide
    Semax
    Outcome
    IncreaseLearning in passive avoidance task, intraperitoneal Semax
    Study

    ratn: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    It was shown that Semax exerts nootropic and analgesic activities following intraperitoneal administration.
    1 context sentence
    Summary · context
    Semax nootropic effects were studied in the test of acquisition of passive avoidance task.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In white rats, intraperitoneal Semax showed analgesic activity in the Randall-Selitto paw-withdrawal test.

    In plain wordsIn rats, Semax given by injection into the abdomen reduced pain sensitivity in a paw-withdrawal test.

    Peptide
    Semax
    Outcome
    DecreasePain sensitivity (Randall-Selitto test), intraperitoneal Semax
    Study

    ratn: not reported in source

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    It was shown that Semax exerts nootropic and analgesic activities following intraperitoneal administration.
    1 context sentence
    Summary · context
    Pain sensitivity was estimated in Randall-Selitto paw-withdrawal test.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In white rats, intranasal Semax improved learning more potently than intraperitoneal Semax.

    In plain wordsIn rats, Semax given through the nose improved learning more than Semax given by injection into the abdomen.

    Peptide
    Semax
    Outcome
    IncreaseLearning improvement, intranasal versus intraperitoneal Semax
    Study

    ratn: not reported in source

    Comparator
    Intraperitoneal Semax
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    Following intranasal administration, Semax was more potent in learning improvement compared to intraperitoneal administration.
    1 context sentence
    Summary · context
    Semax nootropic effects were studied in the test of acquisition of passive avoidance task.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In white rats, intranasal Semax did not affect pain sensitivity, unlike intraperitoneal Semax.

    In plain wordsIn rats, Semax given through the nose did not change pain sensitivity, unlike Semax given by injection into the abdomen.

    Peptide
    Semax
    Outcome
    No significant changePain sensitivity (Randall-Selitto test), intranasal Semax
    Study

    ratn: not reported in source

    Comparator
    Intraperitoneal Semax
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    The peptide failed to affect the animal pain sensitivity following intranasal administration as opposed to intraperitoneal administration.
    1 context sentence
    Summary · context
    Pain sensitivity was estimated in Randall-Selitto paw-withdrawal test.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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