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Study · Animal study (in vivo) · mouse · 2011

2 results

Endurance factors improve hippocampal neurogenesis and spatial memory in mice.

Kobilo T, Yuan C, van Praag H

Learning & memory (Cold Spring Harbor, N.Y.)18 Jan 2011Cited by 96 (Europe PMC)

PMID21245211 (opens in a new tab)PMCIDPMC3032576 (opens in a new tab)DOI10.1101/lm.2001611 (opens in a new tab)PepBankPUB-21245211
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, AICAR treatment for 7 d improved spatial memory.

    In plain wordsIn mice, AICAR treatment for 7 d improved spatial memory.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSpatial memory
    Study

    mousen: not reported in source

    Hippocampus and Morris water maze
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · injection · 7 dAs given in this study (mouse).

    Source sentences

    Summary
    AICAR (7 d) and GW improved spatial memory.
    2 context sentences
    Summary · context
    Mice were injected with GW for 7 d or AICAR for 7 or 14 d.
    Summary · context
    Two weeks thereafter mice were tested in the Morris water maze.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, AICAR significantly increased dentate gyrus neurogenesis.

    In plain wordsIn mice, AICAR increased new nerve cell formation in the dentate gyrus.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseDentate gyrus neurogenesis
    Study

    mousen: not reported in source

    Hippocampus and Morris water maze
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, AICAR significantly, and GW modestly, elevated dentate gyrus neurogenesis.
    2 context sentences
    Summary · context
    Mice were injected with GW for 7 d or AICAR for 7 or 14 d.
    Summary · context
    Two weeks thereafter mice were tested in the Morris water maze.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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