Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability.

Monaselidze JR, Khavinson VKh, Gorgoshidze MZ, Khachidze DG, Lomidze EM, Jokhadze TA, Lezhava TA

Bulletin of experimental biology and medicine1 Jan 2011

PMID21240358DOI10.1007/s10517-011-1146-xPepBankPUB-21240358

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Bronchogen (AEDL) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Bronchogen (AEDL).

01LabNot a test of Bronchogen (AEDL) aloneIn vitro (cell-free)Activity measurement
In cell-free DNA tests, bronchogen increased melting temperature by 3.1°C at molar ratios of 0.01-0.055.
In plain wordsIn lab tests, bronchogen increased DNA melting temperature within a narrow range of peptide-to-DNA ratios.
Peptide
Bronchogen (AEDL)
Outcome
IncreaseDNA melting temperature
Study
n: not reported in source
Calf thymus and mouse liver DNA
Outcome group
Receptor activity and mechanism · Pharmacology
Measurements
Melting temperature increase
3.1°C
calf thymus and mouse liver DNA
Source sentences
Summary
Bronchogen increased the melting temperature of DNA from calf thymus and mouse liver by 3.1°C in a narrow range of r (molar ratio of bronchogen/DNA b.p., 0.01-0.055).
1 context sentence(design, population, supporting numbers)
Summary · context
Thermodynamic parameters of DNA melting in the presence of a peptide bronchogen in various concentrations were estimated on a differential scanning microcalorimeter.
In this study, Bronchogen (AEDL) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Bronchogen (AEDL).
Report a problemFND-2124035801
02LabNot a test of Bronchogen (AEDL) aloneIn vitro (cell-free)Activity measurement
In cell-free DNA tests, further increases in the bronchogen-to-DNA ratio did not change melting temperature.
In plain wordsIn lab tests, higher bronchogen-to-DNA ratios did not change DNA melting temperature.
Peptide
Bronchogen (AEDL)
Outcome
No significant changeDNA melting temperature at higher ratios
Study
n: not reported in source
Calf thymus and mouse liver DNA
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
A further increase in r was not accompanied by changes in the melting temperature.
1 context sentence(design, population, supporting numbers)
Summary · context
Thermodynamic parameters of DNA melting in the presence of a peptide bronchogen in various concentrations were estimated on a differential scanning microcalorimeter.
In this study, Bronchogen (AEDL) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Bronchogen (AEDL).
Report a problemFND-2124035802
03LabNot a test of Bronchogen (AEDL) aloneIn vitro (cell-free)Activity measurement
In cell-free DNA tests, melting enthalpy remained unchanged across bronchogen-to-DNA ratios of 0.01-1.0.
In plain wordsIn lab tests, DNA melting enthalpy remained unchanged across the tested bronchogen-to-DNA ratios.
Peptide
Bronchogen (AEDL)
Outcome
No significant changeDNA melting enthalpy
Study
n: not reported in source
Calf thymus and mouse liver DNA
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
The complex melting enthalpy (ΔH(melt)) remained unchanged in this range of r (0.01-1.0).
1 context sentence(design, population, supporting numbers)
Summary · context
Thermodynamic parameters of DNA melting in the presence of a peptide bronchogen in various concentrations were estimated on a differential scanning microcalorimeter.
In this study, Bronchogen (AEDL) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Bronchogen (AEDL).
Report a problemFND-2124035803
04LabNot a test of Bronchogen (AEDL) aloneIn vitro (cell-free)Activity measurement
In cell-free bronchogen-DNA tests, calf thymus DNA melting enthalpy was 11.4 cal/g.
In plain wordsIn lab tests with bronchogen, calf thymus DNA melting enthalpy was 11.4 cal/g.
Peptide
Bronchogen (AEDL)
Outcome
Not applicableCalf thymus DNA melting enthalpy
Study
n: not reported in source
Calf thymus and mouse liver DNA
Outcome group
Receptor activity and mechanism · Pharmacology
Measurements
Melting enthalpy
11.4 cal/g
thymus DNA
Source sentences
Summary
ΔH(melt) for DNA from the thymus and mouse liver was 11.4 and 12.7 cal/g, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Thermodynamic parameters of DNA melting in the presence of a peptide bronchogen in various concentrations were estimated on a differential scanning microcalorimeter.
In this study, Bronchogen (AEDL) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Bronchogen (AEDL).
Report a problemFND-2124035804
05LabNot a test of Bronchogen (AEDL) aloneIn vitro (cell-free)Activity measurement
In cell-free bronchogen-DNA tests, mouse liver DNA melting enthalpy was 12.7 cal/g.
In plain wordsIn lab tests with bronchogen, mouse liver DNA melting enthalpy was 12.7 cal/g.
Peptide
Bronchogen (AEDL)
Outcome
Not applicableMouse liver DNA melting enthalpy
Study
n: not reported in source
Calf thymus and mouse liver DNA
Outcome group
Receptor activity and mechanism · Pharmacology
Measurements
Melting enthalpy
12.7 cal/g
mouse liver DNA
Source sentences
Summary
ΔH(melt) for DNA from the thymus and mouse liver was 11.4 and 12.7 cal/g, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Thermodynamic parameters of DNA melting in the presence of a peptide bronchogen in various concentrations were estimated on a differential scanning microcalorimeter.
In this study, Bronchogen (AEDL) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Bronchogen (AEDL).
Report a problemFND-2124035805
06LabNot a test of Bronchogen (AEDL) aloneIn vitro (cell-free)Mechanism
In cell-free DNA tests, bronchogen showed neither adenine-thymine nor guanine-cytosine ligand specificity.
In plain wordsIn lab tests, bronchogen did not specifically bind either DNA base-pair type.
Peptide
Bronchogen (AEDL)
Outcome
Not applicableDNA base-pair binding specificity
Study
n: not reported in source
Calf thymus and mouse liver DNA
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Our results indicate that bronchogen is not an adenine-thymine-specific or guanine-cytosine-specific ligand.
1 context sentence(design, population, supporting numbers)
Summary · context
Thermodynamic parameters of DNA melting in the presence of a peptide bronchogen in various concentrations were estimated on a differential scanning microcalorimeter.
In this study, Bronchogen (AEDL) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Bronchogen (AEDL).
Report a problemFND-2124035806
07LabNot a test of Bronchogen (AEDL) aloneIn vitro (cell-free)Mechanism
In cell-free DNA tests, bronchogen binding was described as strong and occasional.
In plain wordsIn lab tests, bronchogen binding to DNA was described as strong and occasional.
Peptide
Bronchogen (AEDL)
Outcome
Not applicableDNA binding type
Study
n: not reported in source
Calf thymus and mouse liver DNA
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
The type of binding is considered as strong and occasional.
1 context sentence(design, population, supporting numbers)
Summary · context
Thermodynamic parameters of DNA melting in the presence of a peptide bronchogen in various concentrations were estimated on a differential scanning microcalorimeter.
In this study, Bronchogen (AEDL) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Bronchogen (AEDL).
Report a problemFND-2124035807
08LabNot a test of Bronchogen (AEDL) aloneIn vitro (cell-free)Mechanism
In cell-free DNA tests, bronchogen bound both strands, mainly at nitrogen bases.
In plain wordsIn lab tests, bronchogen bound both DNA strands, mainly at nitrogen bases.
Peptide
Bronchogen (AEDL)
Outcome
Not applicableDNA strand binding
Study
n: not reported in source
Calf thymus and mouse liver DNA
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
The binding occurs with both strands of DNA (mainly with nitrogen bases).
1 context sentence(design, population, supporting numbers)
Summary · context
Thermodynamic parameters of DNA melting in the presence of a peptide bronchogen in various concentrations were estimated on a differential scanning microcalorimeter.
In this study, Bronchogen (AEDL) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Bronchogen (AEDL).
Report a problemFND-2124035808

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 17:05 UTC
Study results updated
Version 1
21 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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