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Study · Not a test of the peptide alone · 2011

9 results

Thymulin gene therapy prevents the histomorphometric changes induced by thymulin deficiency in the thyrotrope population of mice.

Martines EV, Reggiani PC, Schwerdt JI, Goya RG, Cónsole GM

Cells, tissues, organs7 Jan 2011Cited by 3 (Europe PMC)

PMID21212643 (opens in a new tab)DOI10.1159/000322583 (opens in a new tab)PepBankPUB-21212643
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone9

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 01AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In C57BL/6 mice, thymulin immunoneutralization severely reduced serum thymulin versus normal rabbit serum (p < 0.01).

    In plain wordsIn mice, blocking thymulin severely reduced blood thymulin compared with normal rabbit serum.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseSerum thymulin after immunoneutralization
    Study

    mousen: not reported in source

    C57BL/6 mice
    Comparator
    Normal rabbit serum
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Thymulin immunoneutralization severely reduced serum thymulin (p < 0.01).
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to immunoneutralization of circulating thymulin from postnatal day 1 to the end of the study (postnatal day 32) by intraperitoneal injections of rabbit anti-factor thymulin serum (α-FTS) and normal rabbit serum in controls.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 02AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In C57BL/6 mice of both sexes, thymulin immunoneutralization significantly decreased thyrotrope cell size versus normal rabbit serum.

    In plain wordsIn male and female mice, blocking thymulin significantly decreased thyroid-stimulating cell size compared with normal rabbit serum.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseThyrotrope cell size after immunoneutralization
    Study

    mousen: not reported in source

    C57BL/6 mice of both sexes
    Comparator
    Normal rabbit serum
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    We detected a significant (p < 0.05) decrease in cell size (CS) and volume density (VD) with a nonsignificant decrease in cell density (CD) in C57BL/6 in both males and females.
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to immunoneutralization of circulating thymulin from postnatal day 1 to the end of the study (postnatal day 32) by intraperitoneal injections of rabbit anti-factor thymulin serum (α-FTS) and normal rabbit serum in controls.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  3. 03AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In C57BL/6 mice of both sexes, thymulin immunoneutralization significantly decreased thyrotrope volume density versus normal rabbit serum.

    In plain wordsIn male and female mice, blocking thymulin significantly decreased thyroid-stimulating cell volume density compared with normal rabbit serum.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseThyrotrope volume density after immunoneutralization
    Study

    mousen: not reported in source

    C57BL/6 mice of both sexes
    Comparator
    Normal rabbit serum
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    We detected a significant (p < 0.05) decrease in cell size (CS) and volume density (VD) with a nonsignificant decrease in cell density (CD) in C57BL/6 in both males and females.
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to immunoneutralization of circulating thymulin from postnatal day 1 to the end of the study (postnatal day 32) by intraperitoneal injections of rabbit anti-factor thymulin serum (α-FTS) and normal rabbit serum in controls.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  4. 04AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In C57BL/6 mice of both sexes, thymulin immunoneutralization produced a nonsignificant decrease in thyrotrope cell density versus normal rabbit serum.

    In plain wordsIn male and female mice, blocking thymulin did not significantly change thyroid-stimulating cell density compared with normal rabbit serum.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeThyrotrope cell density after immunoneutralization
    Study

    mousen: not reported in source

    C57BL/6 mice of both sexes
    Comparator
    Normal rabbit serum
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    We detected a significant (p < 0.05) decrease in cell size (CS) and volume density (VD) with a nonsignificant decrease in cell density (CD) in C57BL/6 in both males and females.
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to immunoneutralization of circulating thymulin from postnatal day 1 to the end of the study (postnatal day 32) by intraperitoneal injections of rabbit anti-factor thymulin serum (α-FTS) and normal rabbit serum in controls.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  5. 05AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In athymic mice, neonatal RAd-FTS thymulin gene therapy markedly increased serum thymulin versus the control vector.

    In plain wordsIn athymic mice, thymulin gene therapy markedly increased blood thymulin compared with the control vector.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseSerum thymulin after gene therapy
    Study

    mousen: not reported in source

    Athymic nude mice
    Comparator
    RAd-GFP control vector
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    A single neonatal i.m. injection of RAd-FTS markedly increased the circulating levels of serum thymulin in the athymic mice and increased the CD (p < 0.05), CS (p < 0.01) and VD (p < 0.01) of the thyrotrope population in nu/nu mice.
    1 context sentence
    Summary · context
    Also, neonatal thymulin gene therapy was implemented in athymic nude mice using an adenoviral vector expressing a gene for thymulin (RAd-FTS). On postnatal day 1, heterozygous (nu/+) and homozygous (nu/nu) pups received a single bilateral intramuscular (i.m.) injection of either RAd-FTS or RAd-GFP (…

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  6. 06AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In nu/nu mice, neonatal thymulin gene therapy increased thyrotrope cell density versus the control vector (p < 0.05).

    In plain wordsIn nude mice, thymulin gene therapy increased thyroid-stimulating cell density compared with the control vector.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseThyrotrope cell density after gene therapy
    Study

    mousen: not reported in source

    nu/nu mice
    Comparator
    RAd-GFP control vector
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    A single neonatal i.m. injection of RAd-FTS markedly increased the circulating levels of serum thymulin in the athymic mice and increased the CD (p < 0.05), CS (p < 0.01) and VD (p < 0.01) of the thyrotrope population in nu/nu mice.
    1 context sentence
    Summary · context
    On postnatal day 1, heterozygous (nu/+) and homozygous (nu/nu) pups received a single bilateral intramuscular (i.m.) injection of either RAd-FTS or RAd-GFP (the latter being the control vector).

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  7. 07AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In nu/nu mice, neonatal thymulin gene therapy increased thyrotrope cell size versus the control vector (p < 0.01).

    In plain wordsIn nude mice, thymulin gene therapy increased thyroid-stimulating cell size compared with the control vector.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseThyrotrope cell size after gene therapy
    Study

    mousen: not reported in source

    nu/nu mice
    Comparator
    RAd-GFP control vector
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    A single neonatal i.m. injection of RAd-FTS markedly increased the circulating levels of serum thymulin in the athymic mice and increased the CD (p < 0.05), CS (p < 0.01) and VD (p < 0.01) of the thyrotrope population in nu/nu mice.
    1 context sentence
    Summary · context
    On postnatal day 1, heterozygous (nu/+) and homozygous (nu/nu) pups received a single bilateral intramuscular (i.m.) injection of either RAd-FTS or RAd-GFP (the latter being the control vector).

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  8. 08AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In nu/nu mice, neonatal thymulin gene therapy increased thyrotrope volume density versus the control vector (p < 0.01).

    In plain wordsIn nude mice, thymulin gene therapy increased thyroid-stimulating cell volume density compared with the control vector.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseThyrotrope volume density after gene therapy
    Study

    mousen: not reported in source

    nu/nu mice
    Comparator
    RAd-GFP control vector
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    A single neonatal i.m. injection of RAd-FTS markedly increased the circulating levels of serum thymulin in the athymic mice and increased the CD (p < 0.05), CS (p < 0.01) and VD (p < 0.01) of the thyrotrope population in nu/nu mice.
    1 context sentence
    Summary · context
    On postnatal day 1, heterozygous (nu/+) and homozygous (nu/nu) pups received a single bilateral intramuscular (i.m.) injection of either RAd-FTS or RAd-GFP (the latter being the control vector).

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  9. 09AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In the mouse thymulin manipulation experiments, thyroid histology was not affected.

    In plain wordsIn mice, the thymulin experiments did not affect thyroid tissue structure.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeThyroid histology
    Study

    mousen: not reported in source

    Mice in immunoneutralization and gene therapy experiments
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Thyroid histology was not affected.
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to immunoneutralization of circulating thymulin from postnatal day 1 to the end of the study (postnatal day 32) by intraperitoneal injections of rabbit anti-factor thymulin serum (α-FTS) and normal rabbit serum in controls. Also, neonatal thymulin gene therapy was impleme…

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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