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Study · Measured the body's own peptide · 2011

10 results

Stimulation of mechano-growth factor expression by second messengers.

Kravchenko IV, Furalyov VA, Lisitsina ES, Popov VO

Archives of biochemistry and biophysics28 Dec 2010Cited by 11 (Europe PMC)

PMID21192914 (opens in a new tab)DOI10.1016/j.abb.2010.12.028 (opens in a new tab)PepBankPUB-21192914
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

No result from this study comes from a test of the peptide.

Natural levels measured10

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In murine and human myoblast and myotube cultures, cAMP stimulated the cells' own MGF expression.

    In plain wordsIn mouse and human muscle cells, cAMP raised the cells' own MGF.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF expression with cAMP
    Study

    mouse, humann: not reported in source

    Myoblast and myotube cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    cAMP stimulates MGF expression both in murine and human cells.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    CNG- and HCN-channel blockers slightly activated MGF synthesis in myoblast cultures.

    In plain wordsIn muscle cells, two types of channel blockers slightly raised the cells' own MGF.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF synthesis with CNG- and HCN-channel blockers
    Study

    n: not reported in source

    Myoblast and myotube cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    CNG- and HCN-channel blockers slightly activated MGF synthesis, while an activator of Epac protein had no effect.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    An activator of Epac protein had no effect on MGF synthesis in myoblast cultures.

    In plain wordsIn muscle cells, an Epac activator did not change the cells' own MGF.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeMGF synthesis with Epac activator
    Study

    n: not reported in source

    Myoblast and myotube cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    while an activator of Epac protein had no effect.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelIn vitro (cells)Mechanism

    Phorbol ester (PMA) activated MGF synthesis in human myoblasts and myotubes only.

    In plain wordsIn human muscle cells, PMA raised the cells' own MGF. It did not do so in mouse cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF synthesis with phorbol ester (PMA)
    Study

    humann: not reported in source

    Myoblast and myotube cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    Phorbol ester (PMA) activates MGF synthesis in human myoblasts and myotubes only.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  5. 05LabEndogenous levelIn vitro (cells)Mechanism

    In human cells, db-cAMP and PMA stimulated MGF expression with different time dependences, and the effects were additive in combination.

    In plain wordsIn human muscle cells, db-cAMP and PMA together raised the cells' own MGF more than either alone.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF expression with db-cAMP and PMA combined
    Study

    humann: not reported in source

    Myoblast and myotube cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    Stimulation of MGF expression in human cells by db-cAMP and PMA demonstrated different time dependences but showed additivity when the compounds were applied in a combination.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  6. 06LabEndogenous levelIn vitro (cells)Mechanism

    Inhibitors specific to protein kinase A did not affect PMA-mediated activation of MGF synthesis.

    In plain wordsIn muscle cells, blocking protein kinase A did not stop PMA from raising the cells' own MGF.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changePKA inhibitors on PMA-mediated MGF activation
    Study

    n: not reported in source

    Myoblast and myotube cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    Inhibitors specific to protein kinase A did not affect PMA-mediated activation

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  7. 07LabEndogenous levelIn vitro (cells)Mechanism

    Inhibitors specific to protein kinase C did not affect the db-cAMP-mediated process of MGF synthesis.

    In plain wordsIn muscle cells, blocking protein kinase C did not stop db-cAMP from raising the cells' own MGF.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changePKC inhibitors on db-cAMP-mediated MGF activation
    Study

    n: not reported in source

    Myoblast and myotube cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    while inhibitors specific to protein kinase C did not affect db-cAMP-mediated process.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  8. 08LabEndogenous levelIn vitro (cells)Mechanism

    Ca2+ ionophore strongly inhibited MGF synthesis in myoblast cultures.

    In plain wordsIn muscle cells, a calcium ionophore strongly lowered the cells' own MGF.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMGF synthesis with Ca2+ ionophore
    Study

    n: not reported in source

    Myoblast and myotube cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    Ca²+ ionophore and ROS inductor strongly inhibited synthesis of the growth factor.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  9. 09LabEndogenous levelIn vitro (cells)Mechanism

    A ROS inductor strongly inhibited MGF synthesis in myoblast cultures.

    In plain wordsIn muscle cells, a reactive oxygen species inducer strongly lowered the cells' own MGF.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMGF synthesis with ROS inductor
    Study

    n: not reported in source

    Myoblast and myotube cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    Ca²+ ionophore and ROS inductor strongly inhibited synthesis of the growth factor.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  10. 10LabEndogenous levelIn vitro (cells)Mechanism

    PGE2 stimulated MGF expression in murine and human cells.

    In plain wordsIn mouse and human muscle cells, PGE2 raised the cells' own MGF.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF expression with PGE2
    Study

    mouse, humann: not reported in source

    Myoblast and myotube cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    PGE2 known as physiological stimulator of cAMP synthesis was shown to stimulate MGF expression both in murine and human cells.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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