In bone marrow MSCs from children with aplastic anemia, Tα1 for 18 hours markedly downregulated tlr9 mRNA expression in a concentration- and time-dependent way.
In plain wordsIn lab tests, thymosin alpha‑1 lowered tlr9 mRNA compared with untreated cells.
- Peptide
- Thymosin alpha-1
- Outcome
- Decreasetlr9 mRNA expression in AA MSCs
- Study
humann: not reported in source
Bone marrow mesenchymal stem cells from children with aplastic anemia- Comparator
- Untreated AA MSCs
- Outcome group
- Receptor activity and mechanism · Immune and inflammation
- Studied dose
- Dose not stated · 18 hoursAs given in this study (human).
Source sentences
AA children's MSC treated with Tα1 for 18 hours markedly down-regulated tlr9 mRNA expression, but up-regulated ido mRNA expression in the concentration- and time-dependent ways.
1 context sentence(design, population, supporting numbers)
Culture system of bone marrow MSC from AA children and normal children in vitro was established, and the effects of Tα1 on expressions of tlr9 mRNA and ido mRNA of MSC from AA children and normal children were determined by RT-PCR.