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Study · Animal study (in vivo) · rat · 2011

9 results

A small nonerythropoietic helix B surface peptide based upon erythropoietin structure is cardioprotective against ischemic myocardial damage.

Ahmet I, Tae HJ, Juhaszova M, Riordon DR, Boheler KR, Sollott SJ, Brines M, Cerami A, Lakatta EG, Talan MI

Molecular medicine (Cambridge, Mass.)16 Dec 2010Cited by 39 (Europe PMC)

PMID21170473 (opens in a new tab)PMCIDPMC3060982 (opens in a new tab)DOI10.2119/molmed.2010.00235 (opens in a new tab)PepBankPUB-21170473
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with myocardial infarction, a single bolus of pHBP right after coronary ligation reduced apoptosis in the area at risk by 80% at 24 h, similar to erythropoietin.

    In plain wordsIn rats with a heart attack, one injection of pHBP reduced cell death in the at-risk heart area, like erythropoietin did.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseApoptosis in the myocardial area at risk at 24 h
    Study

    Ratn: not reported in source

    Rat model of myocardial infarction (permanent coronary artery ligation)
    Outcome group
    Myocardial injury · Cardiovascular
    Studied dose
    60 μg/kg · single bolusAs given in this study (Rat).

    Measurements

    Reduction in apoptosis
    80%
    myocardial area at risk, 24 h

    Source sentences

    Summary
    In an experimental model of myocardial infarction induced by permanent ligation of a coronary artery in rats, a single bolus injection of 60 μg/kg of pHBP immediately after coronary ligation, similar to EPO, reduced apoptosis in the myocardial area at risk, examined 24 h later, by 80% and inflammation by 34%.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with myocardial infarction, a single bolus of pHBP right after coronary ligation reduced inflammation in the area at risk by 34% at 24 h, similar to erythropoietin.

    In plain wordsIn rats with a heart attack, one injection of pHBP reduced inflammation in the at-risk heart area, like erythropoietin did.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseInflammation in the myocardial area at risk at 24 h
    Study

    Ratn: not reported in source

    Rat model of myocardial infarction (permanent coronary artery ligation)
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    60 μg/kg · single bolusAs given in this study (Rat).

    Measurements

    Reduction in inflammation
    34%
    myocardial area at risk, 24 h

    Source sentences

    Summary
    In an experimental model of myocardial infarction induced by permanent ligation of a coronary artery in rats, a single bolus injection of 60 μg/kg of pHBP immediately after coronary ligation, similar to EPO, reduced apoptosis in the myocardial area at risk, examined 24 h later, by 80% and inflammation by 34%.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, pHBP reduced myocardial infarction size by 50% at 24 h after coronary ligation, similarly to erythropoietin.

    In plain wordsIn rats, pHBP shrank the heart attack area by half after 24 hours, similar to erythropoietin.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseMyocardial infarction size at 24 h
    Study

    Ratn: not reported in source

    Rat model of myocardial infarction (permanent coronary artery ligation)
    Outcome group
    Myocardial injury · Cardiovascular
    Studied dose
    60 μg/kg · single bolusAs given in this study (Rat).

    Measurements

    Reduction in myocardial infarction
    50%
    24 h after ligation

    Source sentences

    Summary
    Myocardial infarction (MI) measured 24 h after coronary ligation was similarly reduced by 50% in both pHBP- and EPO-treated rats.
    1 context sentence
    Summary · context
    In an experimental model of myocardial infarction induced by permanent ligation of a coronary artery in rats, a single bolus injection of 60 μg/kg of pHBP immediately after coronary ligation, similar to EPO, reduced apoptosis in the myocardial area at risk, examined 24 h later, by 80% and inflammation by 34%.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with myocardial infarction, pHBP significantly attenuated left ventricular remodeling (dilation) at two weeks, similarly to erythropoietin.

    In plain wordsIn rats with a heart attack, pHBP limited enlargement of the heart's main chamber at two weeks, like erythropoietin.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseLeft ventricular remodeling (ventricular dilation) at 2 weeks
    Study

    Ratn: not reported in source

    Rat model of myocardial infarction (permanent coronary artery ligation)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    60 μg/kg · single bolusAs given in this study (Rat).

    Source sentences

    Summary
    Two wks after surgery, left ventricular remodeling (ventricular dilation) and functional decline (fall in ejection fraction) assessed by echocardiography were significantly and similarly attenuated in pHBP- and EPO-treated rats, and MI size was reduced by 25%.
    1 context sentence
    Summary · context
    In an experimental model of myocardial infarction induced by permanent ligation of a coronary artery in rats, a single bolus injection of 60 μg/kg of pHBP immediately after coronary ligation, similar to EPO, reduced apoptosis in the myocardial area at risk, examined 24 h later, by 80% and inflammation by 34%.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with myocardial infarction, pHBP significantly attenuated the fall in ejection fraction at two weeks, similarly to erythropoietin.

    In plain wordsIn rats with a heart attack, pHBP limited the drop in the heart's pumping ability at two weeks, like erythropoietin.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseEjection fraction decline at 2 weeks
    Study

    Ratn: not reported in source

    Rat model of myocardial infarction (permanent coronary artery ligation)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    60 μg/kg · single bolusAs given in this study (Rat).

    Source sentences

    Summary
    Two wks after surgery, left ventricular remodeling (ventricular dilation) and functional decline (fall in ejection fraction) assessed by echocardiography were significantly and similarly attenuated in pHBP- and EPO-treated rats, and MI size was reduced by 25%.
    1 context sentence
    Summary · context
    In an experimental model of myocardial infarction induced by permanent ligation of a coronary artery in rats, a single bolus injection of 60 μg/kg of pHBP immediately after coronary ligation, similar to EPO, reduced apoptosis in the myocardial area at risk, examined 24 h later, by 80% and inflammation by 34%.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with myocardial infarction, pHBP reduced infarct size by 25% at two weeks, and the effect was retained during 6 weeks of follow-up.

    In plain wordsIn rats with a heart attack, pHBP reduced the damaged heart area at two weeks, and the effect lasted through 6 weeks.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseMyocardial infarction size at 2 weeks
    Study

    Ratn: not reported in source

    Rat model of myocardial infarction (permanent coronary artery ligation)
    Outcome group
    Myocardial injury · Cardiovascular
    Studied dose
    60 μg/kg · single bolus; follow-up 6 weeksAs given in this study (Rat).

    Measurements

    Reduction in myocardial infarction size
    25%
    2 weeks after surgery

    Source sentences

    Summary
    Two wks after surgery, left ventricular remodeling (ventricular dilation) and functional decline (fall in ejection fraction) assessed by echocardiography were significantly and similarly attenuated in pHBP- and EPO-treated rats, and MI size was reduced by 25%.
    2 context sentences
    Summary · context
    The effect was retained during the 6-wk follow-up.
    Summary · context
    In an experimental model of myocardial infarction induced by permanent ligation of a coronary artery in rats, a single bolus injection of 60 μg/kg of pHBP immediately after coronary ligation, similar to EPO, reduced apoptosis in the myocardial area at risk, examined 24 h later, by 80% and inflammation by 34%.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats, a single bolus of pHBP given right after coronary ligation reduced infarct size at a dose as low as 1 μg/kg.

    In plain wordsIn rats, a very low single dose of pHBP given right after a heart attack reduced the damaged heart area.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseMyocardial infarction size with 1 μg/kg given immediately after ligation
    Study

    Ratn: not reported in source

    Rat model of myocardial infarction (permanent coronary artery ligation)
    Outcome group
    Myocardial injury · Cardiovascular
    Studied dose
    1 μg/kg · single bolusAs given in this study (Rat).

    Measurements

    Lowest effective dose
    1 μg/kg
    bolus right after ligation

    Source sentences

    Summary
    A single bolus injection of pHBP immediately after coronary ligation was effective in reduction of MI size in a dose as low as 1 μg/kg
    1 context sentence
    Summary · context
    In an experimental model of myocardial infarction induced by permanent ligation of a coronary artery in rats, a single bolus injection of 60 μg/kg of pHBP immediately after coronary ligation, similar to EPO, reduced apoptosis in the myocardial area at risk, examined 24 h later, by 80% and inflammation by 34%.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats, a single bolus of 60 μg/kg pHBP given 24 h after infarction induction did not reduce infarct size.

    In plain wordsIn rats, pHBP given a day after the heart attack did not reduce the damaged heart area.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    No significant changeMyocardial infarction size with delayed dosing 24 h after infarction
    Study

    Ratn: not reported in source

    Rat model of myocardial infarction (permanent coronary artery ligation)
    Outcome group
    Myocardial injury · Cardiovascular
    Studied dose
    60 μg/kg · single bolusAs given in this study (Rat).

    Source sentences

    Summary
    but was ineffective at a 60 μg/kg dose if administered 24 h after MI induction.
    1 context sentence
    Summary · context
    In an experimental model of myocardial infarction induced by permanent ligation of a coronary artery in rats, a single bolus injection of 60 μg/kg of pHBP immediately after coronary ligation, similar to EPO, reduced apoptosis in the myocardial area at risk, examined 24 h later, by 80% and inflammation by 34%.
  9. 09LabIn vitro (cells)Mechanism

    In cardiac myocytes under oxidative stress, HBP increased the reactive oxygen species threshold for induction of the mitochondrial permeability transition by 40%, similar to erythropoietin.

    In plain wordsIn cells, HBP raised the level of oxidative stress that cells can tolerate before mitochondria are damaged, like erythropoietin did.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseROS threshold for mitochondrial permeability transition
    Study

    n: not reported in source

    Cardiac myocytes under oxidative stress
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    Increase in ROS threshold for mitochondrial permeability transition
    40%
    cardiac myocytes

    Source sentences

    Summary
    HBP, similar to EPO, increased the reactive oxygen species (ROS) threshold for induction of the mitochondrial permeability transition by 40%.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

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