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Study · Animal study (in vivo) · rat · 2011

3 results

Melanocortin activity in the amygdala influences alcohol intake.

York DA, Boghossian S, Park-York M

Pharmacology, biochemistry, and behavior15 Dec 2010Cited by 9 (Europe PMC)

PMID21167196 (opens in a new tab)DOI10.1016/j.pbb.2010.12.010 (opens in a new tab)PepBankPUB-21167196
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, amygdala injection of the MC3/MC4R agonist MTII reduced alcohol intake.

    In plain wordsIn rats, MTII injected into the amygdala reduced alcohol intake.

    Peptide
    Melanotan II
    Outcome
    DecreaseAlcohol intake
    Study

    ratn: not reported in source

    alcohol-preferring and non-preferring rats, amygdala injection
    Outcome group
    Appetite and food intake · Mental health and mood
    Studied dose
    Dose not stated · injection at the border of the central and basolateral amygdalaAs given in this study (rat).

    Source sentences

    Summary
    The MC3/MC4R agonist MTII reduced alcohol and food intake but increased water intake
    2 context sentences
    Summary · context
    Since these receptors are expressed in a number of amygdala regions, we have explored their role in the regulation of alcohol intake in both alcohol-preferring (P) and non-preferring (NP) rats.
    Summary · context
    Injections were made at the border of the central amygdala nucleus and the basolateral amygdala.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, amygdala injection of the MC3/MC4R agonist MTII reduced food intake.

    In plain wordsIn rats, MTII injected into the amygdala reduced food intake.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake
    Study

    ratn: not reported in source

    alcohol-preferring and non-preferring rats, amygdala injection
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · injection at the border of the central and basolateral amygdalaAs given in this study (rat).

    Source sentences

    Summary
    The MC3/MC4R agonist MTII reduced alcohol and food intake but increased water intake
    2 context sentences
    Summary · context
    Since these receptors are expressed in a number of amygdala regions, we have explored their role in the regulation of alcohol intake in both alcohol-preferring (P) and non-preferring (NP) rats.
    Summary · context
    Injections were made at the border of the central amygdala nucleus and the basolateral amygdala.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, amygdala injection of the MC3/MC4R agonist MTII increased water intake.

    In plain wordsIn rats, MTII injected into the amygdala increased water intake.

    Peptide
    Melanotan II
    Outcome
    IncreaseWater intake
    Study

    ratn: not reported in source

    alcohol-preferring and non-preferring rats, amygdala injection
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · injection at the border of the central and basolateral amygdalaAs given in this study (rat).

    Source sentences

    Summary
    The MC3/MC4R agonist MTII reduced alcohol and food intake but increased water intake
    2 context sentences
    Summary · context
    Since these receptors are expressed in a number of amygdala regions, we have explored their role in the regulation of alcohol intake in both alcohol-preferring (P) and non-preferring (NP) rats.
    Summary · context
    Injections were made at the border of the central amygdala nucleus and the basolateral amygdala.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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