Effects of growth hormone (GH) replacement and cognitive rehabilitation in patients with cognitive disorders after traumatic brain injury.

Reimunde P, Quintana A, Castañón B, Casteleiro N, Vilarnovo Z, Otero A, Devesa A, Otero-Cepeda XL, Devesa J

Brain injury30 Nov 2010Cited by 77 (Europe PMC)

PMID21117918DOI10.3109/02699052.2010.536196PepBankPUB-21117918

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanNon-randomized trialEfficacy outcome
In adults after traumatic brain injury, the growth hormone-treated deficient group improved similarities more than controls receiving shared rehabilitation (p < 0.01).
In plain wordsIn adults after traumatic brain injury, the growth hormone-treated deficient group improved similarities more than controls receiving shared rehabilitation.
Peptide
HGH (somatotropin)
Outcome
IncreaseSimilarities improvement versus controls
Study
n = 19
Comparator
Vehicle with the same cognitive rehabilitation
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
1 mg/day · subcutaneous · 3 monthsAs given in this study (human).
Source sentences
Summary
GHD reached significantly greater improvements than controls in similarities (p < 0.01) and in vocabulary, verbal IQ and total IQ (p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Nineteen adult patients with TBI: GHD was found in 11 of them.InterventionPatients were treated with GH (GHD; sc; 1 mg/day) or vehicle (controls; sc; 1 mg/day); daily cognitive rehabilitation therapy was performed in both groups for 3 months.
Report a problemFND-2111791801
02HumanNon-randomized trialEfficacy outcome
In adults after traumatic brain injury, the growth hormone-treated deficient group improved vocabulary more than controls receiving shared rehabilitation (p < 0.05).
In plain wordsIn adults after traumatic brain injury, the growth hormone-treated deficient group improved vocabulary more than controls receiving shared rehabilitation.
Peptide
HGH (somatotropin)
Outcome
IncreaseVocabulary improvement versus controls
Study
n = 19
Comparator
Vehicle with the same cognitive rehabilitation
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
1 mg/day · subcutaneous · 3 monthsAs given in this study (human).
Source sentences
Summary
GHD reached significantly greater improvements than controls in similarities (p < 0.01) and in vocabulary, verbal IQ and total IQ (p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Nineteen adult patients with TBI: GHD was found in 11 of them.InterventionPatients were treated with GH (GHD; sc; 1 mg/day) or vehicle (controls; sc; 1 mg/day); daily cognitive rehabilitation therapy was performed in both groups for 3 months.
Report a problemFND-2111791802
03HumanNon-randomized trialEfficacy outcome
In adults after traumatic brain injury, the growth hormone-treated deficient group improved verbal IQ more than controls receiving shared rehabilitation (p < 0.05).
In plain wordsIn adults after traumatic brain injury, the growth hormone-treated deficient group improved verbal IQ more than controls receiving shared rehabilitation.
Peptide
HGH (somatotropin)
Outcome
IncreaseVerbal IQ improvement versus controls
Study
n = 19
Comparator
Vehicle with the same cognitive rehabilitation
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
1 mg/day · subcutaneous · 3 monthsAs given in this study (human).
Source sentences
Summary
GHD reached significantly greater improvements than controls in similarities (p < 0.01) and in vocabulary, verbal IQ and total IQ (p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Nineteen adult patients with TBI: GHD was found in 11 of them.InterventionPatients were treated with GH (GHD; sc; 1 mg/day) or vehicle (controls; sc; 1 mg/day); daily cognitive rehabilitation therapy was performed in both groups for 3 months.
Report a problemFND-2111791803
04HumanNon-randomized trialEfficacy outcome
In adults after traumatic brain injury, the growth hormone-treated deficient group improved total IQ more than controls receiving shared rehabilitation (p < 0.05).
In plain wordsIn adults after traumatic brain injury, the growth hormone-treated deficient group improved total IQ more than controls receiving shared rehabilitation.
Peptide
HGH (somatotropin)
Outcome
IncreaseTotal IQ improvement versus controls
Study
n = 19
Comparator
Vehicle with the same cognitive rehabilitation
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
1 mg/day · subcutaneous · 3 monthsAs given in this study (human).
Source sentences
Summary
GHD reached significantly greater improvements than controls in similarities (p < 0.01) and in vocabulary, verbal IQ and total IQ (p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Nineteen adult patients with TBI: GHD was found in 11 of them.InterventionPatients were treated with GH (GHD; sc; 1 mg/day) or vehicle (controls; sc; 1 mg/day); daily cognitive rehabilitation therapy was performed in both groups for 3 months.
Report a problemFND-2111791804
05HumanNon-randomized trialActivity measurement
In adults after traumatic brain injury, plasma IGF-I at treatment end was similar in the growth hormone-treated deficient group and controls.
In plain wordsIn adults after traumatic brain injury, plasma IGF-I was similar in the growth hormone-treated deficient group and controls at treatment end.
Peptide
HGH (somatotropin)
Outcome
No significant changePlasma IGF-I at end of treatment
Study
n = 19
Comparator
Vehicle with the same cognitive rehabilitation
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1 mg/day · subcutaneous · 3 monthsAs given in this study (human).
Source sentences
Summary
Since at the end of treatment period plasma IGF-I levels were similar in both groups
1 context sentence(design, population, supporting numbers)
Summary · context
Nineteen adult patients with TBI: GHD was found in 11 of them.InterventionPatients were treated with GH (GHD; sc; 1 mg/day) or vehicle (controls; sc; 1 mg/day); daily cognitive rehabilitation therapy was performed in both groups for 3 months.
Report a problemFND-2111791805

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownPhase 2NCT04121780

Growth Hormone Replacement Therapy for Retried Professional Football Players

Center for Neurological Studiesn = 428 Oct 2019 to est. Sept 2026

TBI (Traumatic Brain Injury) · Concussion, Brain · Sport Injury · Anterior Pituitary Hyposecretion Syndrome · Hypopituitarism · Growth Hormone Deficiency

Trial page ClinicalTrials.govUpdated 8 Feb 2023

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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