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Study · Non-randomized trial · 2011

3 results

Oxytocin can hinder trust and cooperation in borderline personality disorder.

Bartz J, Simeon D, Hamilton H, Kim S, Crystal S, Braun A, Vicens V, Hollander E

Social cognitive and affective neuroscience29 Nov 2010Cited by 266 (Europe PMC)

PMID21115541 (opens in a new tab)PMCIDPMC3190211 (opens in a new tab)DOI10.1093/scan/nsq085 (opens in a new tab)PepBankPUB-21115541
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In adults with borderline personality disorder, intranasal oxytocin decreased trust in a social dilemma game.

    In plain wordsIn people with borderline personality disorder, nasal oxytocin lowered trust in a partner during a social game.

    Peptide
    Oxytocin
    Outcome
    DecreaseTrust in social dilemma game
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Results showed that OXT produced divergent effects in BPD participants, decreasing trust
    1 context sentence
    Summary · context
    BPD and control participants received intranasal OXT and played a social dilemma game with a partner.
  2. 02HumanNon-randomized trialEfficacy outcome

    In adults with borderline personality disorder, intranasal oxytocin decreased the likelihood of cooperative responses in a social dilemma game.

    In plain wordsIn people with borderline personality disorder, nasal oxytocin made cooperative choices less likely in a social game.

    Peptide
    Oxytocin
    Outcome
    DecreaseLikelihood of cooperative responses
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Results showed that OXT produced divergent effects in BPD participants, decreasing trust and the likelihood of cooperative responses.
    1 context sentence
    Summary · context
    BPD and control participants received intranasal OXT and played a social dilemma game with a partner.
  3. 03HumanNon-randomized trialMechanism

    Across participants with borderline personality disorder and controls, the divergent oxytocin effects were driven by anxiously attached, rejection-sensitive participants.

    In plain wordsThe different effects of nasal oxytocin on trust were driven by anxiously attached, rejection-sensitive people.

    Peptide
    Oxytocin
    Outcome
    Not applicableModeration of oxytocin effects by attachment style
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Additional analyses focusing on individual differences in attachment anxiety and avoidance across BPD and control participants indicate that these divergent effects were driven by the anxiously attached, rejection-sensitive participants.
    1 context sentence
    Summary · context
    BPD and control participants received intranasal OXT and played a social dilemma game with a partner.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 1Results postedNCT01834261

Brain Dynamics of Oxytocin

Stony Brook Universityn = 51Apr 2013 to May 2015

Brain Dynamics in Healthy Adults

Trial pageClinicalTrials.govUpdated 17 Mar 2017

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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