In rats under acute and chronic immobilization stress, repeated intranasal Semax had a protective antistress effect against hypercoagulation, shown as stimulation of the anticoagulation system.
In plain wordsIn rats under stress, repeated nasal Semax stimulated the blood anticoagulation system and protected against stress-related clotting.
- Peptide
- Semax
- Outcome
- IncreaseAnticoagulation system activity under immobilization stress
- Study
ratn: not reported in source
Acute and chronic immobilization stress (albino rats)- Outcome group
- Cardiovascular events · Cardiovascular
- Studied dose
- Dose not stated · intranasalAs given in this study (rat).
Source sentences
Semax exhibited a protective antistress effect after repeated intranasal administration under conditions of hypercoagulation developing in response to immobilization stress of different degree. The effect manifested in stimulation of the anticoagulation system.
1 context sentence(design, population, supporting numbers)
The effects of semax on anticoagulant, fibrinolytic, and platelet components of the anticoagulation system were studied on albino rats under conditions of acute and chronic immobilization stress.