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Study · Animal study (in vivo) · mouse · 2011

9 results

Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: a role of β₂-adrenergic receptor activation.

Tadaishi M, Miura S, Kai Y, Kawasaki E, Koshinaka K, Kawanaka K, Nagata J, Oishi Y, Ezaki O

American journal of physiology. Endocrinology and metabolism23 Nov 2010Cited by 91 (Europe PMC)

PMID21098736 (opens in a new tab)DOI10.1152/ajpendo.00400.2010 (opens in a new tab)PepBankPUB-21098736
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, a single AICAR injection increased PGC-1α-a mRNA.

    In plain wordsIn mice, an AICAR injection increased PGC-1α-a gene activity.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePGC-1alpha-a mRNA
    Study

    mousen: not reported in source

    Skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    A single injection in mice of AICAR, an AMPK activator, increased mRNAs of all PGC-1α isoforms.
    1 context sentence
    Summary · context
    Compared with PGC-1α-a mRNA, PGC-1α-b or PGC-1α-c mRNA is transcribed by a different exon 1 of the PGC-1α gene.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, a single AICAR injection increased PGC-1α-b mRNA.

    In plain wordsIn mice, an AICAR injection increased PGC-1α-b gene activity.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePGC-1alpha-b mRNA
    Study

    mousen: not reported in source

    Skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    A single injection in mice of AICAR, an AMPK activator, increased mRNAs of all PGC-1α isoforms.
    1 context sentence
    Summary · context
    Compared with PGC-1α-a mRNA, PGC-1α-b or PGC-1α-c mRNA is transcribed by a different exon 1 of the PGC-1α gene.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, a single AICAR injection increased PGC-1α-c mRNA.

    In plain wordsIn mice, an AICAR injection increased PGC-1α-c gene activity.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePGC-1alpha-c mRNA
    Study

    mousen: not reported in source

    Skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    A single injection in mice of AICAR, an AMPK activator, increased mRNAs of all PGC-1α isoforms.
    1 context sentence
    Summary · context
    Compared with PGC-1α-a mRNA, PGC-1α-b or PGC-1α-c mRNA is transcribed by a different exon 1 of the PGC-1α gene.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, AICAR increased blood catecholamine concentrations.

    In plain wordsIn mice, AICAR increased blood catecholamine levels.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseBlood catecholamine concentration
    Study

    mousen: not reported in source

    Skeletal muscle
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    AICAR increased blood catecholamine concentrations, and preinjection of β₂-AR antagonist inhibited the increase in PGC-1α-b and PGC-1α-c mRNAs but not the increase in PGC-1α-a mRNA.
  5. 05LabEx vivo tissueMechanism

    In isolated epitrochlearis muscle, direct AICAR exposure increased PGC-1α-a expression.

    In plain wordsIn lab tests with isolated muscle, AICAR increased PGC-1α-a gene activity.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePGC-1alpha-a mRNA in exposed muscle
    Study

    n: not reported in source

    Epitrochlearis muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Direct exposure of epitrochlearis muscle to AICAR increased PGC-1α-a but not the -b isoform.
  6. 06LabEx vivo tissueMechanism

    In isolated epitrochlearis muscle, direct AICAR exposure did not increase PGC-1α-b expression.

    In plain wordsIn lab tests with isolated muscle, AICAR did not increase PGC-1α-b gene activity.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changePGC-1alpha-b mRNA in exposed muscle
    Study

    n: not reported in source

    Epitrochlearis muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Direct exposure of epitrochlearis muscle to AICAR increased PGC-1α-a but not the -b isoform.

Studies that did not test the peptide alone3

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 07AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In mice, beta-adrenergic receptor antagonist pretreatment inhibited AICAR-induced PGC-1α-b mRNA elevation.

    In plain wordsIn mice, receptor blockade reduced the increase in PGC-1α-b gene activity after AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseAntagonist-sensitive PGC-1alpha-b induction
    Study

    mousen: not reported in source

    Skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    AICAR increased blood catecholamine concentrations, and preinjection of β₂-AR antagonist inhibited the increase in PGC-1α-b and PGC-1α-c mRNAs but not the increase in PGC-1α-a mRNA.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 08AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In mice, beta-adrenergic receptor antagonist pretreatment inhibited AICAR-induced PGC-1α-c mRNA elevation.

    In plain wordsIn mice, receptor blockade reduced the increase in PGC-1α-c gene activity after AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseAntagonist-sensitive PGC-1alpha-c induction
    Study

    mousen: not reported in source

    Skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    AICAR increased blood catecholamine concentrations, and preinjection of β₂-AR antagonist inhibited the increase in PGC-1α-b and PGC-1α-c mRNAs but not the increase in PGC-1α-a mRNA.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  3. 09AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In mice, beta-adrenergic receptor antagonist pretreatment did not inhibit AICAR-induced PGC-1α-a mRNA elevation.

    In plain wordsIn mice, receptor blockade did not inhibit the increase in PGC-1α-a gene activity after AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeAntagonist-resistant PGC-1alpha-a induction
    Study

    mousen: not reported in source

    Skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    AICAR increased blood catecholamine concentrations, and preinjection of β₂-AR antagonist inhibited the increase in PGC-1α-b and PGC-1α-c mRNAs but not the increase in PGC-1α-a mRNA.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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