Mechano growth factor E peptide promotes osteoblasts proliferation and bone-defect healing in rabbits.

Deng M, Zhang B, Wang K, Liu F, Xiao H, Zhao J, Liu P, Li Y, Lin F, Wang Y

International orthopaedics6 Nov 2010Cited by 36 (Europe PMC)

PMID21057789PMCIDPMC3167400DOI10.1007/s00264-010-1141-2PepBankPUB-21057789

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rabbits with a 5-mm radius defect, high-dose MGF-Ct24E raised the cumulative rate of radiographically healed defects versus no treatment (p < 0.01).
In plain wordsIn rabbits, the high dose of the MGF E peptide led to more healed bone defects than no treatment.
Peptide
MGF / PEG-MGF
Outcome
IncreaseRadiographic healing rate of radius bone defect
Study
rabbitn: not reported in source
5-mm segmental radius defect
Comparator
Non-growth factor injection
Outcome group
Bone and joint · Musculoskeletal
Studied dose
57 μg /kg body weight · five consecutive daysAs given in this study (rabbit).
Source sentences
Summary
The cumulative rate of radiographically healed defects and histological scores of bone defect-healing revealed a statistical difference between high-dose treatment and non treatment (p < 0.01), which showed the treatment promoted defect healing.
1 context sentence(design, population, supporting numbers)
Summary · context
In vivo, a 5-mm segmental bone defect in the radius of 27 rabbits was treated with MGF-Ct24E by two doses (28.5 and 57 μg /kg body weight) vs. non-growth factor injection for five consecutive days postoperatively.
Report a problemFND-2105778904
02AnimalAnimal study (in vivo)Efficacy outcome
In rabbits with a 5-mm radius defect, high-dose MGF-Ct24E gave higher histological scores of bone-defect healing than no treatment (p < 0.01).
In plain wordsIn rabbits, the high dose of the MGF E peptide gave better bone-healing scores under the microscope than no treatment.
Peptide
MGF / PEG-MGF
Outcome
IncreaseHistological score of bone-defect healing
Study
rabbitn: not reported in source
5-mm segmental radius defect
Comparator
Non-growth factor injection
Outcome group
Bone and joint · Musculoskeletal
Studied dose
57 μg /kg body weight · five consecutive daysAs given in this study (rabbit).
Source sentences
Summary
The cumulative rate of radiographically healed defects and histological scores of bone defect-healing revealed a statistical difference between high-dose treatment and non treatment (p < 0.01), which showed the treatment promoted defect healing.
1 context sentence(design, population, supporting numbers)
Summary · context
In vivo, a 5-mm segmental bone defect in the radius of 27 rabbits was treated with MGF-Ct24E by two doses (28.5 and 57 μg /kg body weight) vs. non-growth factor injection for five consecutive days postoperatively.
Report a problemFND-2105778905
03LabIn vitro (cells)Efficacy outcome
In MC3T3-E1 osteoblast-like cells, MGF-Ct24E had the highest pro-proliferation activity among MGF, MGF-Ct24E and IGF-1, 1.4 times that of IGF-1.
In plain wordsIn cells, the MGF E peptide made bone-like cells multiply more than MGF or IGF-1 did.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMC3T3-E1 osteoblast-like cell proliferation versus MGF and IGF-1
Study
n: not reported in source
MC3T3-E1 osteoblast-like cells
Comparator
MGF and IGF-1
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Measurements
Proliferation activity relative to IGF-1
1.4 times
MGF-Ct24E
Source sentences
Summary
MGF-Ct24E had the highest pro-proliferation activity among three growth factors, which was 1.4 times greater than that of IGF-1.
1 context sentence(design, population, supporting numbers)
Summary · context
we firstly investigated the effects of growth factors, including MGF, its E peptide (a short 24-amino acid C-terminal peptide, MGF-Ct24E), and insulin-like growth factor 1(IGF-1) on MC3T3-E1 osteoblast-like cell proliferation.
Report a problemFND-2105778901
04LabIn vitro (cells)Mechanism
In MC3T3-E1 cells, MGF-Ct24E promoted proliferation by inducing cell cycle arrest in the S and G2/M phase.
In plain wordsIn cells, the MGF E peptide caused cells to pause in certain cell cycle phases while boosting growth.
Peptide
MGF / PEG-MGF
Outcome
IncreaseCell cycle arrest in S and G2/M phase
Study
n: not reported in source
MC3T3-E1 osteoblast-like cells
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
MGF-Ct24E promoted cell proliferation by inducing cell cycle arrest in the S and G(2)/M phase of the cell cycle
Report a problemFND-2105778902
05LabIn vitro (cells)Mechanism
In MC3T3-E1 cells, MGF-Ct24E promoted proliferation mainly by activating the MAPK-Erk1/2 pathway.
In plain wordsIn cells, the MGF E peptide switched on the MAPK-Erk1/2 signalling pathway, which drove cell growth.
Peptide
MGF / PEG-MGF
Outcome
IncreaseActivation of MAPK-Erk1/2 pathway
Study
n: not reported in source
MC3T3-E1 osteoblast-like cells
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
but also mainly by the activation of the MAPK-Erk1/2 pathway.
Report a problemFND-2105778903

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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