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Study · Animal study (in vivo) · 2011

4 results

Nanostructured porous silicon microparticles enable sustained peptide (Melanotan II) delivery.

Kilpeläinen M, Mönkäre J, Vlasova MA, Riikonen J, Lehto VP, Salonen J, Järvinen K, Herzig KH

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V20 Oct 2010Cited by 36 (Europe PMC)

PMID20965250 (opens in a new tab)DOI10.1016/j.ejpb.2010.10.004 (opens in a new tab)PepBankPUB-20965250
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In vivo after subcutaneous dosing, MTII loaded on THCPSi increased heart rate 2 h later than MTII solution, and the effect lasted 1 h longer.

    In plain wordsIn animals, Melanotan II loaded on silicon particles raised heart rate later and for longer than Melanotan II solution.

    Peptide
    Melanotan II
    Outcome
    IncreaseHeart rate time course
    Study

    n: not reported in source

    Comparator
    MTII solution
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · subcutaneousAs given in this study.

    Source sentences

    Summary
    In vivo, MTII loaded THCPSi induced an increase in the heart rate 2 h later than MTII solution, and the effect lasted 1 h longer.
    1 context sentence
    Summary · context
    The effects of MTII on heart rate and water consumption were investigated in vivo after subcutaneous administration of the MTII loaded microparticles.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In vivo, MTII loaded on THCPSi changed water consumption after 150 min, when the effect of MTII solution had already diminished; the direction is not stated.

    In plain wordsIn animals, Melanotan II on silicon particles changed water drinking later than Melanotan II solution did.

    Peptide
    Melanotan II
    Outcome
    Direction not reportedWater consumption time course
    Study

    n: not reported in source

    Comparator
    MTII solution
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · subcutaneousAs given in this study.

    Source sentences

    Summary
    In addition, MTII loaded THCPSi changed the water consumption after 150 min, when the immediate effect of MTII solution was already diminished.
    1 context sentence
    Summary · context
    The effects of MTII on heart rate and water consumption were investigated in vivo after subcutaneous administration of the MTII loaded microparticles.

Studies that did not test the peptide alone2

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 03LabNot a test of Melanotan II aloneIn vitro (cell-free)Other

    Thermally hydrocarbonized nanoporous silicon microparticles reached a Melanotan II loading degree of 15% w/w.

    In plain wordsIn lab tests, tiny silicon particles could carry Melanotan II at 15% of their weight.

    Peptide
    Melanotan II
    Outcome
    Not applicablePeptide loading degree of porous silicon microparticles
    Study

    n: not reported in source

    Outcome group
    Formulation, delivery and stability · Pharmacology

    Measurements

    Peptide loading degree
    15 % w/w
    THCPSi microparticles

    Source sentences

    Summary
    A peptide loading degree of 15% w/w was obtained.
    1 context sentence
    Summary · context
    Thermally hydrocarbonized nanoporous silicon (THCPSi) microparticles (38-53 μm) were loaded with MTII.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

  2. 04LabNot a test of Melanotan II aloneIn vitro (cell-free)Other

    In vitro in PBS at pH 7.4 and 37 °C, THCPSi microparticles released MTII in a sustained manner.

    In plain wordsIn lab tests, the silicon particles released Melanotan II slowly over time.

    Peptide
    Melanotan II
    Outcome
    Not applicableIn vitro release of MTII from microparticles
    Study

    n: not reported in source

    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    In vitro studies (PBS, pH 7.4, 37 °C) indicated sustained release of MTII from the THCPSi microparticles.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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