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Study · Animal study (in vivo) · cynomolgus monkeys · 2011

10 results

Changes in the contents of enzymatic immature, mature, and non-enzymatic senescent cross-links of collagen after once-weekly treatment with human parathyroid hormone (1-34) for 18 months contribute to improvement of bone strength in ovariectomized monkeys.

Saito M, Marumo K, Kida Y, Ushiku C, Kato S, Takao-Kawabata R, Kuroda T

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA20 Oct 2010Cited by 58 (Europe PMC)

PMID20959962 (opens in a new tab)DOI10.1007/s00198-010-1454-4 (opens in a new tab)PepBankPUB-20959962
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized monkeys, low-dose hPTH increased immature enzymatic cross-links versus the OVX group.

    In plain wordsIn ovariectomized monkeys, low-dose hPTH increased immature enzymatic collagen cross-links versus untreated ovariectomized monkeys.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseImmature enzymatic collagen cross-links
    Study

    Cynomolgus monkeysn: not reported in source

    Ovariectomized adult female monkeys
    Comparator
    OVX group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.2 μg/kg once weekly · subcutaneous · 18 monthsAs given in this study (Cynomolgus monkeys).

    Source sentences

    Summary
    Low-PTH and high-hPTH treatments increased the content of enzymatic immature and mature cross-links, bone volume (BV/TV), and trabecular thickness, and decreased pentosidine, compared with the OVX group.
    1 context sentence
    Summary · context
    Adult female cynomolgus monkeys were divided into four groups (n = 18-20 each) as follows: SHAM group, OVX group, and OVX monkeys given once-weekly subcutaneous injections of hPTH(1-34) either at 1.2 or 6.0 μg/kg (low- or high-PTH groups) for 18 months.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized monkeys, high-dose hPTH increased immature enzymatic cross-links versus the OVX group.

    In plain wordsIn ovariectomized monkeys, high-dose hPTH increased immature enzymatic collagen cross-links versus untreated ovariectomized monkeys.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseImmature enzymatic collagen cross-links
    Study

    Cynomolgus monkeysn: not reported in source

    Ovariectomized adult female monkeys
    Comparator
    OVX group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    6.0 μg/kg once weekly · subcutaneous · 18 monthsAs given in this study (Cynomolgus monkeys).

    Source sentences

    Summary
    Low-PTH and high-hPTH treatments increased the content of enzymatic immature and mature cross-links, bone volume (BV/TV), and trabecular thickness, and decreased pentosidine, compared with the OVX group.
    1 context sentence
    Summary · context
    Adult female cynomolgus monkeys were divided into four groups (n = 18-20 each) as follows: SHAM group, OVX group, and OVX monkeys given once-weekly subcutaneous injections of hPTH(1-34) either at 1.2 or 6.0 μg/kg (low- or high-PTH groups) for 18 months.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized monkeys, low-dose hPTH increased mature enzymatic cross-links versus the OVX group.

    In plain wordsIn ovariectomized monkeys, low-dose hPTH increased mature enzymatic collagen cross-links versus untreated ovariectomized monkeys.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMature enzymatic collagen cross-links
    Study

    Cynomolgus monkeysn: not reported in source

    Ovariectomized adult female monkeys
    Comparator
    OVX group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.2 μg/kg once weekly · subcutaneous · 18 monthsAs given in this study (Cynomolgus monkeys).

    Source sentences

    Summary
    Low-PTH and high-hPTH treatments increased the content of enzymatic immature and mature cross-links, bone volume (BV/TV), and trabecular thickness, and decreased pentosidine, compared with the OVX group.
    1 context sentence
    Summary · context
    Adult female cynomolgus monkeys were divided into four groups (n = 18-20 each) as follows: SHAM group, OVX group, and OVX monkeys given once-weekly subcutaneous injections of hPTH(1-34) either at 1.2 or 6.0 μg/kg (low- or high-PTH groups) for 18 months.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized monkeys, high-dose hPTH increased mature enzymatic cross-links versus the OVX group.

    In plain wordsIn ovariectomized monkeys, high-dose hPTH increased mature enzymatic collagen cross-links versus untreated ovariectomized monkeys.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMature enzymatic collagen cross-links
    Study

    Cynomolgus monkeysn: not reported in source

    Ovariectomized adult female monkeys
    Comparator
    OVX group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    6.0 μg/kg once weekly · subcutaneous · 18 monthsAs given in this study (Cynomolgus monkeys).

    Source sentences

    Summary
    Low-PTH and high-hPTH treatments increased the content of enzymatic immature and mature cross-links, bone volume (BV/TV), and trabecular thickness, and decreased pentosidine, compared with the OVX group.
    1 context sentence
    Summary · context
    Adult female cynomolgus monkeys were divided into four groups (n = 18-20 each) as follows: SHAM group, OVX group, and OVX monkeys given once-weekly subcutaneous injections of hPTH(1-34) either at 1.2 or 6.0 μg/kg (low- or high-PTH groups) for 18 months.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized monkeys, low-dose hPTH increased BV/TV versus the OVX group.

    In plain wordsIn ovariectomized monkeys, low-dose hPTH increased bone volume fraction versus untreated ovariectomized monkeys.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone volume fraction
    Study

    Cynomolgus monkeysn: not reported in source

    Ovariectomized adult female monkeys
    Comparator
    OVX group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.2 μg/kg once weekly · subcutaneous · 18 monthsAs given in this study (Cynomolgus monkeys).

    Source sentences

    Summary
    Low-PTH and high-hPTH treatments increased the content of enzymatic immature and mature cross-links, bone volume (BV/TV), and trabecular thickness, and decreased pentosidine, compared with the OVX group.
    1 context sentence
    Summary · context
    Adult female cynomolgus monkeys were divided into four groups (n = 18-20 each) as follows: SHAM group, OVX group, and OVX monkeys given once-weekly subcutaneous injections of hPTH(1-34) either at 1.2 or 6.0 μg/kg (low- or high-PTH groups) for 18 months.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized monkeys, high-dose hPTH increased BV/TV versus the OVX group.

    In plain wordsIn ovariectomized monkeys, high-dose hPTH increased bone volume fraction versus untreated ovariectomized monkeys.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone volume fraction
    Study

    Cynomolgus monkeysn: not reported in source

    Ovariectomized adult female monkeys
    Comparator
    OVX group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    6.0 μg/kg once weekly · subcutaneous · 18 monthsAs given in this study (Cynomolgus monkeys).

    Source sentences

    Summary
    Low-PTH and high-hPTH treatments increased the content of enzymatic immature and mature cross-links, bone volume (BV/TV), and trabecular thickness, and decreased pentosidine, compared with the OVX group.
    1 context sentence
    Summary · context
    Adult female cynomolgus monkeys were divided into four groups (n = 18-20 each) as follows: SHAM group, OVX group, and OVX monkeys given once-weekly subcutaneous injections of hPTH(1-34) either at 1.2 or 6.0 μg/kg (low- or high-PTH groups) for 18 months.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized monkeys, low-dose hPTH increased trabecular thickness versus the OVX group.

    In plain wordsIn ovariectomized monkeys, low-dose hPTH increased bone strut thickness versus untreated ovariectomized monkeys.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTrabecular thickness
    Study

    Cynomolgus monkeysn: not reported in source

    Ovariectomized adult female monkeys
    Comparator
    OVX group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.2 μg/kg once weekly · subcutaneous · 18 monthsAs given in this study (Cynomolgus monkeys).

    Source sentences

    Summary
    Low-PTH and high-hPTH treatments increased the content of enzymatic immature and mature cross-links, bone volume (BV/TV), and trabecular thickness, and decreased pentosidine, compared with the OVX group.
    1 context sentence
    Summary · context
    Adult female cynomolgus monkeys were divided into four groups (n = 18-20 each) as follows: SHAM group, OVX group, and OVX monkeys given once-weekly subcutaneous injections of hPTH(1-34) either at 1.2 or 6.0 μg/kg (low- or high-PTH groups) for 18 months.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized monkeys, high-dose hPTH increased trabecular thickness versus the OVX group.

    In plain wordsIn ovariectomized monkeys, high-dose hPTH increased bone strut thickness versus untreated ovariectomized monkeys.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTrabecular thickness
    Study

    Cynomolgus monkeysn: not reported in source

    Ovariectomized adult female monkeys
    Comparator
    OVX group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    6.0 μg/kg once weekly · subcutaneous · 18 monthsAs given in this study (Cynomolgus monkeys).

    Source sentences

    Summary
    Low-PTH and high-hPTH treatments increased the content of enzymatic immature and mature cross-links, bone volume (BV/TV), and trabecular thickness, and decreased pentosidine, compared with the OVX group.
    1 context sentence
    Summary · context
    Adult female cynomolgus monkeys were divided into four groups (n = 18-20 each) as follows: SHAM group, OVX group, and OVX monkeys given once-weekly subcutaneous injections of hPTH(1-34) either at 1.2 or 6.0 μg/kg (low- or high-PTH groups) for 18 months.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized monkeys, low-dose hPTH decreased pentosidine versus the OVX group.

    In plain wordsIn ovariectomized monkeys, low-dose hPTH decreased pentosidine versus untreated ovariectomized monkeys.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreasePentosidine content
    Study

    Cynomolgus monkeysn: not reported in source

    Ovariectomized adult female monkeys
    Comparator
    OVX group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.2 μg/kg once weekly · subcutaneous · 18 monthsAs given in this study (Cynomolgus monkeys).

    Source sentences

    Summary
    Low-PTH and high-hPTH treatments increased the content of enzymatic immature and mature cross-links, bone volume (BV/TV), and trabecular thickness, and decreased pentosidine, compared with the OVX group.
    1 context sentence
    Summary · context
    Adult female cynomolgus monkeys were divided into four groups (n = 18-20 each) as follows: SHAM group, OVX group, and OVX monkeys given once-weekly subcutaneous injections of hPTH(1-34) either at 1.2 or 6.0 μg/kg (low- or high-PTH groups) for 18 months.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized monkeys, high-dose hPTH decreased pentosidine versus the OVX group.

    In plain wordsIn ovariectomized monkeys, high-dose hPTH decreased pentosidine versus untreated ovariectomized monkeys.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreasePentosidine content
    Study

    Cynomolgus monkeysn: not reported in source

    Ovariectomized adult female monkeys
    Comparator
    OVX group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    6.0 μg/kg once weekly · subcutaneous · 18 monthsAs given in this study (Cynomolgus monkeys).

    Source sentences

    Summary
    Low-PTH and high-hPTH treatments increased the content of enzymatic immature and mature cross-links, bone volume (BV/TV), and trabecular thickness, and decreased pentosidine, compared with the OVX group.
    1 context sentence
    Summary · context
    Adult female cynomolgus monkeys were divided into four groups (n = 18-20 each) as follows: SHAM group, OVX group, and OVX monkeys given once-weekly subcutaneous injections of hPTH(1-34) either at 1.2 or 6.0 μg/kg (low- or high-PTH groups) for 18 months.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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