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Study · Animal study (in vivo) · goldfish · 2011

3 results

Gonadotropin-releasing hormone II (GnRH II) mediates the anorexigenic actions of α-melanocyte-stimulating hormone (α-MSH) and corticotropin-releasing hormone (CRH) in goldfish.

Kang KS, Shimizu K, Azuma M, Ui Y, Nakamura K, Uchiyama M, Matsuda K

Peptides16 Oct 2010Cited by 28 (Europe PMC)

PMID20955748 (opens in a new tab)DOI10.1016/j.peptides.2010.10.013 (opens in a new tab)PepBankPUB-20955748
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In goldfish, intracerebroventricular melanotan II significantly reduced food intake.

    In plain wordsIn goldfish, melanotan II injected into the brain reduced food intake.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake after melanotan II
    Study

    goldfishn: not reported in source

    goldfish, intracerebroventricular injection
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    80 pmol/g body weight · intracerebroventricularAs given in this study (goldfish).

    Source sentences

    Summary
    ICV injection of the MC4R agonist, melanotan II (80 pmol/g body weight; BW), significantly reduced food intake
  2. 02AnimalAnimal study (in vivo)Mechanism

    In goldfish, pre-administration of the GnRH type I receptor antagonist antide suppressed the food-intake reduction caused by melanotan II.

    In plain wordsIn goldfish, blocking the GnRH receptor with antide stopped melanotan II from reducing food intake.

    Peptide
    Melanotan II
    Outcome
    No significant changeMelanotan II anorexigenic effect after GnRH receptor antagonist antide
    Study

    goldfishn: not reported in source

    goldfish, intracerebroventricular injection
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    80 pmol/g body weight · intracerebroventricularAs given in this study (goldfish).

    Source sentences

    Summary
    ICV injection of the MC4R agonist, melanotan II (80 pmol/g body weight; BW), significantly reduced food intake, and its anorexigenic effect was suppressed by ICV pre-administration of the GnRH type I receptor antagonist, antide (100 pmol/gBW).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In goldfish, intracerebroventricular melanotan II had no effect on hypothalamic GnRH II mRNA level.

    In plain wordsIn goldfish, melanotan II did not change GnRH II gene activity in the hypothalamus.

    Peptide
    Melanotan II
    Outcome
    No significant changeHypothalamic GnRH II mRNA after melanotan II
    Study

    goldfishn: not reported in source

    goldfish, intracerebroventricular injection
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    80 pmol/g body weight · intracerebroventricularAs given in this study (goldfish).

    Source sentences

    Summary
    while ICV injection of melanotan II (80 pmol/gBW) had no effect on the level of GnRH II mRNA.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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