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Study · Animal study (in vivo) · sheep · 2011

4 results

Prepubertal gonadotropin-releasing hormone analog leads to exaggerated behavioral and emotional sex differences in sheep.

Wojniusz S, Vögele C, Ropstad E, Evans N, Robinson J, Sütterlin S, Erhard HW, Solbakk AK, Endestad T, Olberg DE, Haraldsen IR

Hormones and behavior8 Oct 2010Cited by 22 (Europe PMC)

PMID20934426 (opens in a new tab)DOI10.1016/j.yhbeh.2010.09.010 (opens in a new tab)PepBankPUB-20934426
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male sheep, goserelin increased the likelihood of leaving companions to acquire food compared with untreated males.

    In plain wordsIn male sheep, goserelin increased the likelihood of leaving companions to acquire food compared with untreated males.

    Peptide
    Goserelin
    Outcome
    IncreaseFood acquisition behavior in males
    Study

    Sheepn: not reported in source

    Prepubertal Scottish mule Texel cross sheep
    Comparator
    Untreated sheep of the same sex
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Every 3 weeksAs given in this study (Sheep).

    Source sentences

    Summary
    ANOVA revealed significant sex and sex×treatment interaction effects, suggesting that treated males were more likely to leave their companions to acquire food than untreated, while the opposite effect was observed in females.
    2 context sentences
    Summary · context
    We blocked puberty in half of the 48 same-sex Scottish mule Texel cross sheep twins with GnRH analog (GnRHa) goserelin acetate every 3 weeks, beginning just before puberty.
    Summary · context
    To determine the effects of GnRHa treatment on sex-specific behavior and emotion regulation in different social contexts, we employed the food acquisition task (FAT) and measurement of heart rate variability (HRV).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female sheep, goserelin decreased the likelihood of leaving companions to acquire food compared with untreated females.

    In plain wordsIn female sheep, goserelin decreased the likelihood of leaving companions to acquire food compared with untreated females.

    Peptide
    Goserelin
    Outcome
    DecreaseFood acquisition behavior in females
    Study

    Sheepn: not reported in source

    Prepubertal Scottish mule Texel cross sheep
    Comparator
    Untreated sheep of the same sex
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Every 3 weeksAs given in this study (Sheep).

    Source sentences

    Summary
    ANOVA revealed significant sex and sex×treatment interaction effects, suggesting that treated males were more likely to leave their companions to acquire food than untreated, while the opposite effect was observed in females.
    2 context sentences
    Summary · context
    We blocked puberty in half of the 48 same-sex Scottish mule Texel cross sheep twins with GnRH analog (GnRHa) goserelin acetate every 3 weeks, beginning just before puberty.
    Summary · context
    To determine the effects of GnRHa treatment on sex-specific behavior and emotion regulation in different social contexts, we employed the food acquisition task (FAT) and measurement of heart rate variability (HRV).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male sheep, heart rate variability was higher with goserelin than in untreated males.

    In plain wordsIn male sheep, heart rate variability was higher with goserelin than in untreated males.

    Peptide
    Goserelin
    Outcome
    IncreaseHeart rate variability in males
    Study

    Sheepn: not reported in source

    Prepubertal Scottish mule Texel cross sheep
    Comparator
    Untreated sheep of the same sex
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Every 3 weeksAs given in this study (Sheep).

    Source sentences

    Summary
    Concordant results were seen in HRV; treated males displayed higher HRV than untreated, while the reverse pattern was found in females, as shown by significant sex and sex×treatment interaction effects.
    2 context sentences
    Summary · context
    We blocked puberty in half of the 48 same-sex Scottish mule Texel cross sheep twins with GnRH analog (GnRHa) goserelin acetate every 3 weeks, beginning just before puberty.
    Summary · context
    To determine the effects of GnRHa treatment on sex-specific behavior and emotion regulation in different social contexts, we employed the food acquisition task (FAT) and measurement of heart rate variability (HRV).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In female sheep, heart rate variability was lower with goserelin than in untreated females.

    In plain wordsIn female sheep, heart rate variability was lower with goserelin than in untreated females.

    Peptide
    Goserelin
    Outcome
    DecreaseHeart rate variability in females
    Study

    Sheepn: not reported in source

    Prepubertal Scottish mule Texel cross sheep
    Comparator
    Untreated sheep of the same sex
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Every 3 weeksAs given in this study (Sheep).

    Source sentences

    Summary
    Concordant results were seen in HRV; treated males displayed higher HRV than untreated, while the reverse pattern was found in females, as shown by significant sex and sex×treatment interaction effects.
    2 context sentences
    Summary · context
    We blocked puberty in half of the 48 same-sex Scottish mule Texel cross sheep twins with GnRH analog (GnRHa) goserelin acetate every 3 weeks, beginning just before puberty.
    Summary · context
    To determine the effects of GnRHa treatment on sex-specific behavior and emotion regulation in different social contexts, we employed the food acquisition task (FAT) and measurement of heart rate variability (HRV).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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