Study · Animal study (in vivo) · mouse · 2010
2 resultsZheng Q, Zhu J, Shanabrough M, Borok E, Benoit SC, Horvath TL, Clegg DJ, Reizes O
Neuroscience23 Oct 2010Cited by 17 (Europe PMC)
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Text rights: Publisher copyright. Results still quote short attributed sentences.
2 results from studies that gave the peptide. No result from this study comes from people.
In syndecan-3 null mice, the melanocortin agonist Melanotan II potently suppressed food intake.
In plain wordsIn mice lacking syndecan-3, Melanotan II strongly reduced food intake.
mousen: not reported in source
Syndecan-3 null (SDC-3(-/-)) miceSource sentences
the melanocortin agonist Melanotan II (MTII) potently suppresses food intake
In syndecan-3 null mice, Melanotan II activated the hypothalamic paraventricular nuclei, as shown by c-fos immunoreactivity.
In plain wordsIn mice lacking syndecan-3, Melanotan II switched on nerve cells in a brain region that controls feeding.
mousen: not reported in source
Syndecan-3 null (SDC-3(-/-)) miceSource sentences
the melanocortin agonist Melanotan II (MTII) potently suppresses food intake and activates the hypothalamic paraventricular nuclei (PVN) in SDC-3(-/-) mice based on c-fos immunoreactivity.
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Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC
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