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Study · Animal study (in vivo) · rat · 2010

3 results

[Experimental optimization of learning and memory processes by selank].

Semenova TP, Kozlovskiĭ II, Zakharova NM, Kozlovskaia MM

Eksperimental'naia i klinicheskaia farmakologiia1 Aug 2010Cited by 2 (Europe PMC)

PMID20919548 (opens in a new tab)PepBankPUB-20919548
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In Wistar rats, a single injection of selank increased serotonin metabolism in the hypothalamus for 30 min to 2 h.

    In plain wordsIn rats, one injection of selank increased serotonin turnover in the hypothalamus for 30 minutes to 2 hours.

    Peptide
    Selank
    Outcome
    IncreaseSerotonin metabolism in hypothalamus
    Study

    ratn: not reported in source

    Wistar rats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    300 microg/kgAs given in this study (rat).

    Source sentences

    Summary
    A single injection of selank activated the metabolism of 5-HT in the hypothalamus and caudal brain stem for 30 min to 2 h.
    2 context sentences
    Summary · context
    The effect of selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), which is a synthetic derivative of the endogenous tetrapeptide tuftsin (stable with respect to tissue peptidases), on the learning and memory processes and metabolism of serotonin (5-HT) have been experimentally studied on Wistar rats.
    Summary · context
    Selank (300 microg/kg) or saline were injected after the 10th trial.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In Wistar rats, a single injection of selank increased serotonin metabolism in the caudal brain stem for 30 min to 2 h.

    In plain wordsIn rats, one injection of selank increased serotonin turnover in the lower brain stem for 30 minutes to 2 hours.

    Peptide
    Selank
    Outcome
    IncreaseSerotonin metabolism in caudal brain stem
    Study

    ratn: not reported in source

    Wistar rats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    300 microg/kgAs given in this study (rat).

    Source sentences

    Summary
    A single injection of selank activated the metabolism of 5-HT in the hypothalamus and caudal brain stem for 30 min to 2 h.
    2 context sentences
    Summary · context
    The effect of selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), which is a synthetic derivative of the endogenous tetrapeptide tuftsin (stable with respect to tissue peptidases), on the learning and memory processes and metabolism of serotonin (5-HT) have been experimentally studied on Wistar rats.
    Summary · context
    Selank (300 microg/kg) or saline were injected after the 10th trial.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats trained with a food reward, selank injected after the 10th trial increased memory trace stability during 30 days.

    In plain wordsIn rats, selank given during learning made the memory last more stably for 30 days compared with saline.

    Peptide
    Selank
    Outcome
    IncreaseMemory trace stability over 30 days
    Study

    ratn: not reported in source

    Wistar rats
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    300 microg/kgAs given in this study (rat).

    Source sentences

    Summary
    It was established that selank induces an increase in memory trace stability during 30 days.
    2 context sentences
    Summary · context
    The effect of selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), which is a synthetic derivative of the endogenous tetrapeptide tuftsin (stable with respect to tissue peptidases), on the learning and memory processes and metabolism of serotonin (5-HT) have been experimentally studied on Wistar rats.
    Summary · context
    Selank (300 microg/kg) or saline were injected after the 10th trial.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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