Migration and proliferation of human mesenchymal stem cells is stimulated by different regions of the mechano-growth factor prohormone.

Collins JM, Goldspink PH, Russell B

Journal of molecular and cellular cardiology27 Sept 2010Cited by 31 (Europe PMC)

PMID20875825PMCIDPMC2989540DOI10.1016/j.yjmcc.2010.09.017PepBankPUB-20875825

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In human mesenchymal stem cells, an E-domain peptide analog of the MGF prohormone increased chemotactic migration after 20 h.
In plain wordsIn lab tests, a part of the MGF peptide made human stem cells move more.
Peptide
MGF / PEG-MGF
Outcome
IncreasehMSC chemotactic migration
Study
humann: not reported in source
Human mesenchymal stem cells in culture
Outcome group
Muscle injury and repair · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Chemotactic migration of hMSCs increased in response to a peptide analog corresponding to the E-domain region of the MGF prohormone
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, the response of human mesenchymal stem cells (hMSCs) was studied in culture with mechano-growth factor (MGF), an isoform of IGF-1 known to be expressed in the heart following injury.
Report a problemFND-2087582501
02LabIn vitro (cells)Efficacy outcome
In human mesenchymal stem cells, migration with the MGF E-domain peptide analog was greater than with the IGF-1 polypeptide after 20 h.
In plain wordsIn lab tests, a part of the MGF peptide moved human stem cells more than IGF-1 did.
Peptide
MGF / PEG-MGF
Outcome
IncreasehMSC chemotactic migration versus IGF-1
Study
humann: not reported in source
Human mesenchymal stem cells in culture
Comparator
IGF-1 polypeptide
Outcome group
Muscle injury and repair · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
which was greater than the IGF-1 polypeptide after 20 h of culture
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, the response of human mesenchymal stem cells (hMSCs) was studied in culture with mechano-growth factor (MGF), an isoform of IGF-1 known to be expressed in the heart following injury.
Report a problemFND-2087582502
03LabIn vitro (cells)Efficacy outcome
In human mesenchymal stem cells, the E-domain peptide (MGF-E) had no effect on proliferation.
In plain wordsIn lab tests, the MGF-E peptide did not change how fast human stem cells multiplied.
Peptide
MGF / PEG-MGF
Outcome
No significant changehMSC proliferation
Study
humann: not reported in source
Human mesenchymal stem cells in culture
Outcome group
Muscle injury and repair · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
whereas the E-domain peptide (MGF-E) had no effect on proliferation.
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, the response of human mesenchymal stem cells (hMSCs) was studied in culture with mechano-growth factor (MGF), an isoform of IGF-1 known to be expressed in the heart following injury.
Report a problemFND-2087582503

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.