In rats with intracerebral hemorrhage, selank had no effect on hematoma volume or perifocal edema, which fell on day 10 in all groups including the saline control.
In plain wordsIn rats with brain bleeding, selank did not change clot size or swelling. These fell in all groups, including saline-treated rats.
- Peptide
- Selank
- Outcome
- No significant changeHematoma volume and perifocal edema
- Study
ratn = 15
Intracerebral hemorrhage by double autologous blood injection- Comparator
- Saline
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- 300 mkg/kg/day · intraperitonealAs given in this study (rat).
Source sentences
The effect of neuropeptides on the functional restoration in animals, in the absence of the effect on hematoma volume and perifocal edema, was found. The significant reduction of perifocal edema and hematoma volume was observed in the 10th day after the hematoma formation in all experimental groups (p < 0.05).
3 context sentences(design, population, supporting numbers)
The double autologous blood injection in the basal nucleus was used as a model of intracerebral hemorrhage.
Animals ware randomly divided into three groups--the control group (n = 5) was treated with saline, the second group (n = 5) was injected with MIF in dose 150 mkg/ kg/day, the third group (n = 5) received Selank in dose 300 mkg/kg/day.
Intraperitoneal injection of peptides was used.