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Study · Measured the body's own peptide · 2010

1 result

GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients.

Doessing S, Holm L, Heinemeier KM, Feldt-Rasmussen U, Schjerling P, Qvortrup K, Larsen JO, Nielsen RH, Flyvbjerg A, Kjaer M

European journal of endocrinology21 Sept 2010Cited by 43 (Europe PMC)

PMID20858702 (opens in a new tab)DOI10.1530/eje-10-0818 (opens in a new tab)PepBankPUB-20858702
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients with acromegaly, natural IGF1Ec (MGF) mRNA expression in muscle was higher than in patients with GH deficiency.

    In plain wordsIn people with acromegaly, the body's own MGF mRNA in muscle was higher than in people with growth hormone deficiency.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseIGF1Ec (MGF) mRNA in muscle
    Study

    n = 18

    Comparator
    GH-deficient patients
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    IGF1Ea and IGF1Ec mRNA expression in muscle was higher in ACRO patients versus GHD patients (P<0.01).
    1 context sentence
    Summary · context
    As primary outcomes, collagen mRNA expression and collagen protein fractional synthesis rate (FSR) were determined locally in skeletal muscle and tendon in nine ACRO and nine GHD patients.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownNot applicableNCT04998500

Growth Hormone as a Model for Reversible Activation of Adipose Tissue Fibrosis

University of Aarhusn = 101 Aug 2021 to est. 31 Dec 2023

Fibrosis

Trial pageClinicalTrials.govUpdated 30 May 2023

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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