Growth hormone releasing peptide-2, a ghrelin agonist, attenuates lipopolysaccharide-induced acute lung injury in rats.

Li G, Li J, Zhou Q, Song X, Liang H, Huang L

The Tohoku journal of experimental medicine1 Sept 2010Cited by 20 (Europe PMC)

PMID20805679DOI10.1620/tjem.222.7PepBankPUB-20805679

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with LPS-induced acute lung injury, GHRP‑2 given before LPS attenuated lung tissue injury on histopathology.
In plain wordsIn rats, GHRP‑2 given before LPS reduced lung tissue damage.
Peptide
GHRP-2
Outcome
DecreaseLung tissue injury (histopathology)
Study
rat (Sprague-Dawley, male)n: not reported in source
LPS-induced acute lung injury
Comparator
LPS-treated rats without GHRP-2
Outcome group
Inflammation markers · Respiratory
Studied dose
100 microg/kg · subcutaneousAs given in this study (rat (Sprague-Dawley, male)).
Source sentences
Summary
In contrast, these lung injury indexes were attenuated in rats that received a subcutaneous injection of GHRP-2 (100 microg/kg) 0.5 h prior to LPS administration.
2 context sentences(design, population, supporting numbers)
Summary · context
lung tissue injury (histopathological examination)
Summary · context
Male Sprague-Dawley rats were intratracheally instilled with LPS (2 mg/kg) to induce ALI.
Report a problemFND-2080567901
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with LPS-induced acute lung injury, GHRP‑2 given before LPS attenuated lung edema measured by wet-to-dry weight ratio.
In plain wordsIn rats, GHRP‑2 given before LPS reduced fluid build-up in the lungs.
Peptide
GHRP-2
Outcome
DecreaseLung edema (wet-to-dry weight ratio)
Study
rat (Sprague-Dawley, male)n: not reported in source
LPS-induced acute lung injury
Comparator
LPS-treated rats without GHRP-2
Outcome group
Inflammation markers · Respiratory
Studied dose
100 microg/kg · subcutaneousAs given in this study (rat (Sprague-Dawley, male)).
Source sentences
Summary
In contrast, these lung injury indexes were attenuated in rats that received a subcutaneous injection of GHRP-2 (100 microg/kg) 0.5 h prior to LPS administration.
2 context sentences(design, population, supporting numbers)
Summary · context
enhanced lung edema (wet-to-dry weight ratio)
Summary · context
Male Sprague-Dawley rats were intratracheally instilled with LPS (2 mg/kg) to induce ALI.
Report a problemFND-2080567902
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with LPS-induced acute lung injury, GHRP‑2 given before LPS attenuated neutrophil infiltration measured by myeloperoxidase activity.
In plain wordsIn rats, GHRP‑2 given before LPS reduced white blood cell build-up in the lungs.
Peptide
GHRP-2
Outcome
DecreaseNeutrophil infiltration (myeloperoxidase activity)
Study
rat (Sprague-Dawley, male)n: not reported in source
LPS-induced acute lung injury
Comparator
LPS-treated rats without GHRP-2
Outcome group
Inflammation markers · Respiratory
Studied dose
100 microg/kg · subcutaneousAs given in this study (rat (Sprague-Dawley, male)).
Source sentences
Summary
In contrast, these lung injury indexes were attenuated in rats that received a subcutaneous injection of GHRP-2 (100 microg/kg) 0.5 h prior to LPS administration.
2 context sentences(design, population, supporting numbers)
Summary · context
neutrophil infiltration (myeloperoxidase activity)
Summary · context
Male Sprague-Dawley rats were intratracheally instilled with LPS (2 mg/kg) to induce ALI.
Report a problemFND-2080567903
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with LPS-induced acute lung injury, GHRP‑2 given before LPS attenuated the rise in total cells in bronchoalveolar lavage fluid.
In plain wordsIn rats, GHRP‑2 given before LPS reduced the number of cells in lung wash fluid.
Peptide
GHRP-2
Outcome
DecreaseBALF total cells (pulmonary permeability)
Study
rat (Sprague-Dawley, male)n: not reported in source
LPS-induced acute lung injury
Comparator
LPS-treated rats without GHRP-2
Outcome group
Inflammation markers · Respiratory
Studied dose
100 microg/kg · subcutaneousAs given in this study (rat (Sprague-Dawley, male)).
Source sentences
Summary
In contrast, these lung injury indexes were attenuated in rats that received a subcutaneous injection of GHRP-2 (100 microg/kg) 0.5 h prior to LPS administration.
2 context sentences(design, population, supporting numbers)
Summary · context
significant increases in pulmonary permeability (total cells and protein)
Summary · context
Male Sprague-Dawley rats were intratracheally instilled with LPS (2 mg/kg) to induce ALI.
Report a problemFND-2080567904
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with LPS-induced acute lung injury, GHRP‑2 given before LPS attenuated the rise in protein in bronchoalveolar lavage fluid.
In plain wordsIn rats, GHRP‑2 given before LPS reduced protein leak into the lungs.
Peptide
GHRP-2
Outcome
DecreaseBALF protein (pulmonary permeability)
Study
rat (Sprague-Dawley, male)n: not reported in source
LPS-induced acute lung injury
Comparator
LPS-treated rats without GHRP-2
Outcome group
Inflammation markers · Respiratory
Studied dose
100 microg/kg · subcutaneousAs given in this study (rat (Sprague-Dawley, male)).
Source sentences
Summary
In contrast, these lung injury indexes were attenuated in rats that received a subcutaneous injection of GHRP-2 (100 microg/kg) 0.5 h prior to LPS administration.
2 context sentences(design, population, supporting numbers)
Summary · context
significant increases in pulmonary permeability (total cells and protein)
Summary · context
Male Sprague-Dawley rats were intratracheally instilled with LPS (2 mg/kg) to induce ALI.
Report a problemFND-2080567905
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with LPS-induced acute lung injury, GHRP‑2 given before LPS attenuated the rise in TNF-alpha in bronchoalveolar lavage fluid.
In plain wordsIn rats, GHRP‑2 given before LPS lowered the inflammatory signal TNF-alpha in the lungs.
Peptide
GHRP-2
Outcome
DecreaseBALF TNF-alpha
Study
rat (Sprague-Dawley, male)n: not reported in source
LPS-induced acute lung injury
Comparator
LPS-treated rats without GHRP-2
Outcome group
Inflammation markers · Respiratory
Studied dose
100 microg/kg · subcutaneousAs given in this study (rat (Sprague-Dawley, male)).
Source sentences
Summary
In contrast, these lung injury indexes were attenuated in rats that received a subcutaneous injection of GHRP-2 (100 microg/kg) 0.5 h prior to LPS administration.
2 context sentences(design, population, supporting numbers)
Summary · context
the levels of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6)
Summary · context
Male Sprague-Dawley rats were intratracheally instilled with LPS (2 mg/kg) to induce ALI.
Report a problemFND-2080567906
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with LPS-induced acute lung injury, GHRP‑2 given before LPS attenuated the rise in IL-6 in bronchoalveolar lavage fluid.
In plain wordsIn rats, GHRP‑2 given before LPS lowered the inflammatory signal IL-6 in the lungs.
Peptide
GHRP-2
Outcome
DecreaseBALF IL-6
Study
rat (Sprague-Dawley, male)n: not reported in source
LPS-induced acute lung injury
Comparator
LPS-treated rats without GHRP-2
Outcome group
Inflammation markers · Respiratory
Studied dose
100 microg/kg · subcutaneousAs given in this study (rat (Sprague-Dawley, male)).
Source sentences
Summary
In contrast, these lung injury indexes were attenuated in rats that received a subcutaneous injection of GHRP-2 (100 microg/kg) 0.5 h prior to LPS administration.
2 context sentences(design, population, supporting numbers)
Summary · context
the levels of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6)
Summary · context
Male Sprague-Dawley rats were intratracheally instilled with LPS (2 mg/kg) to induce ALI.
Report a problemFND-2080567907
08AnimalAnimal study (in vivo)Mechanism
In rats with LPS-induced acute lung injury, pretreatment with GHRP‑2 markedly suppressed NF-kappaB activation in lung tissue at 6 h.
In plain wordsIn rats, GHRP‑2 given before LPS strongly reduced activation of the inflammatory pathway NF-kappaB in the lungs.
Peptide
GHRP-2
Outcome
DecreaseNF-kappaB activation in lung tissue
Study
rat (Sprague-Dawley, male)n: not reported in source
LPS-induced acute lung injury
Comparator
LPS-treated rats without GHRP-2
Outcome group
Receptor activity and mechanism · Respiratory
Studied dose
100 microg/kg · subcutaneousAs given in this study (rat (Sprague-Dawley, male)).
Source sentences
Summary
We thus found that pretreatment with GHRP-2 markedly suppressed the activation of NF-kappaB in lung tissues.
2 context sentences(design, population, supporting numbers)
Summary · context
we assessed of nuclear factor-kappaB (NF-kappaB) activity in lung tissues at 6 h after LPS challenge
Summary · context
Male Sprague-Dawley rats were intratracheally instilled with LPS (2 mg/kg) to induce ALI.
Report a problemFND-2080567908

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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