Effect of MTII on food intake and brain c-Fos in melanocortin-3, melanocortin-4, and double MC3 and MC4 receptor knockout mice.

Rowland NE, Schaub JW, Robertson KL, Andreasen A, Haskell-Luevano C

Peptides26 Aug 2010Cited by 40 (Europe PMC)

PMID20800636PMCIDPMC2967649DOI10.1016/j.peptides.2010.08.016PepBankPUB-20800636

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In wild-type mice, MTII injected into the anterior cerebral ventricle caused strong anorexia.
In plain wordsIn mice, Melanotan II injected into the brain strongly reduced eating.
Peptide
Melanotan II
Outcome
DecreaseFood intake, wild-type mice
Study
mousen: not reported in source
Wild-type mice
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Wild type (WT) mice showed a strong anorexia
1 context sentence(design, population, supporting numbers)
Summary · context
Mice with genomic knockout of either melanocortin type 3 receptors (MC3R-/-), type 4 receptors (MC4R-/-) or knockout of both (double knockout, DKO) were tested for their anorectic response to the mixed MC3/4R agonist, MTII, injected into the anterior cerebral ventricle.
Report a problemFND-2080063601
02AnimalAnimal study (in vivo)Efficacy outcome
In MC3R and MC4R double knockout mice, MTII had no anorectic effect.
In plain wordsIn mice lacking both receptors, Melanotan II did not reduce eating.
Peptide
Melanotan II
Outcome
No significant changeFood intake, double knockout mice
Study
mousen: not reported in source
MC3R and MC4R double knockout mice
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
as expected, DKO were completely unresponsive to MTII.
1 context sentence(design, population, supporting numbers)
Summary · context
Mice with genomic knockout of either melanocortin type 3 receptors (MC3R-/-), type 4 receptors (MC4R-/-) or knockout of both (double knockout, DKO) were tested for their anorectic response to the mixed MC3/4R agonist, MTII, injected into the anterior cerebral ventricle.
Report a problemFND-2080063602
03AnimalAnimal study (in vivo)Efficacy outcome
In MC3R-/- mice, MTII produced a partial anorectic response.
In plain wordsIn mice lacking the MC3 receptor, Melanotan II still reduced eating, but less than in normal mice.
Peptide
Melanotan II
Outcome
DecreaseFood intake, MC3R knockout mice
Study
mousen: not reported in source
MC3R knockout mice
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
In contrast, both MC3R-/- and MC4R-/- showed a partial anorectic response.
1 context sentence(design, population, supporting numbers)
Summary · context
Mice with genomic knockout of either melanocortin type 3 receptors (MC3R-/-), type 4 receptors (MC4R-/-) or knockout of both (double knockout, DKO) were tested for their anorectic response to the mixed MC3/4R agonist, MTII, injected into the anterior cerebral ventricle.
Report a problemFND-2080063603
04AnimalAnimal study (in vivo)Efficacy outcome
In MC4R-/- mice, MTII produced a partial anorectic response.
In plain wordsIn mice lacking the MC4 receptor, Melanotan II still reduced eating, but less than in normal mice.
Peptide
Melanotan II
Outcome
DecreaseFood intake, MC4R knockout mice
Study
mousen: not reported in source
MC4R knockout mice
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
In contrast, both MC3R-/- and MC4R-/- showed a partial anorectic response.
1 context sentence(design, population, supporting numbers)
Summary · context
Mice with genomic knockout of either melanocortin type 3 receptors (MC3R-/-), type 4 receptors (MC4R-/-) or knockout of both (double knockout, DKO) were tested for their anorectic response to the mixed MC3/4R agonist, MTII, injected into the anterior cerebral ventricle.
Report a problemFND-2080063604
05AnimalAnimal study (in vivo)Mechanism
Compared with wild type, MC4R-/- mice showed no MTII-induced c-Fos activation in the area postrema.
In plain wordsIn mice lacking the MC4 receptor, Melanotan II did not switch on a brain-activity marker in one brain area, unlike normal mice.
Peptide
Melanotan II
Outcome
DecreaseMTII-induced c-Fos in area postrema, MC4R knockout mice
Study
mousen: not reported in source
MC4R knockout mice
Comparator
Wild-type mice
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Compared with WT, MC4R-/- showed no activation in AP
2 context sentences(design, population, supporting numbers)
Summary · context
Induction of c-Fos immunoreactivity by MTII was examined in brain regions including paraventricular hypothalamus (PVN) and area postrema (AP).
Summary · context
Mice with genomic knockout of either melanocortin type 3 receptors (MC3R-/-), type 4 receptors (MC4R-/-) or knockout of both (double knockout, DKO) were tested for their anorectic response to the mixed MC3/4R agonist, MTII, injected into the anterior cerebral ventricle.
Report a problemFND-2080063605
06AnimalAnimal study (in vivo)Mechanism
Compared with wild type, MC4R-/- mice showed normal MTII-induced c-Fos activation in the paraventricular hypothalamus.
In plain wordsIn mice lacking the MC4 receptor, Melanotan II switched on a brain-activity marker in this area as in normal mice.
Peptide
Melanotan II
Outcome
No significant changeMTII-induced c-Fos in paraventricular hypothalamus, MC4R knockout mice
Study
mousen: not reported in source
MC4R knockout mice
Comparator
Wild-type mice
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
but showed normal activation in PVN
2 context sentences(design, population, supporting numbers)
Summary · context
Induction of c-Fos immunoreactivity by MTII was examined in brain regions including paraventricular hypothalamus (PVN) and area postrema (AP).
Summary · context
Mice with genomic knockout of either melanocortin type 3 receptors (MC3R-/-), type 4 receptors (MC4R-/-) or knockout of both (double knockout, DKO) were tested for their anorectic response to the mixed MC3/4R agonist, MTII, injected into the anterior cerebral ventricle.
Report a problemFND-2080063606
07AnimalAnimal study (in vivo)Mechanism
Compared with wild type, MC3R-/- mice showed reduced MTII-induced c-Fos activation in the paraventricular hypothalamus.
In plain wordsIn mice lacking the MC3 receptor, Melanotan II switched on a brain-activity marker less in this area than in normal mice.
Peptide
Melanotan II
Outcome
DecreaseMTII-induced c-Fos in paraventricular hypothalamus, MC3R knockout mice
Study
mousen: not reported in source
MC3R knockout mice
Comparator
Wild-type mice
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
whereas MC3R-/- showed reduced activation in PVN but not in AP.
2 context sentences(design, population, supporting numbers)
Summary · context
Induction of c-Fos immunoreactivity by MTII was examined in brain regions including paraventricular hypothalamus (PVN) and area postrema (AP).
Summary · context
Mice with genomic knockout of either melanocortin type 3 receptors (MC3R-/-), type 4 receptors (MC4R-/-) or knockout of both (double knockout, DKO) were tested for their anorectic response to the mixed MC3/4R agonist, MTII, injected into the anterior cerebral ventricle.
Report a problemFND-2080063607
08AnimalAnimal study (in vivo)Mechanism
Compared with wild type, MC3R-/- mice showed no reduction in MTII-induced c-Fos activation in the area postrema.
In plain wordsIn mice lacking the MC3 receptor, Melanotan II switched on a brain-activity marker in this area as in normal mice.
Peptide
Melanotan II
Outcome
No significant changeMTII-induced c-Fos in area postrema, MC3R knockout mice
Study
mousen: not reported in source
MC3R knockout mice
Comparator
Wild-type mice
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
but not in AP.
2 context sentences(design, population, supporting numbers)
Summary · context
Induction of c-Fos immunoreactivity by MTII was examined in brain regions including paraventricular hypothalamus (PVN) and area postrema (AP).
Summary · context
Mice with genomic knockout of either melanocortin type 3 receptors (MC3R-/-), type 4 receptors (MC4R-/-) or knockout of both (double knockout, DKO) were tested for their anorectic response to the mixed MC3/4R agonist, MTII, injected into the anterior cerebral ventricle.
Report a problemFND-2080063608

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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