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Study · Animal study (in vivo) · rat · 2010

6 results

[Protective antithrombotic effects of proline-containing peptides in the animal body subjected to stress].

Liapina LA, Grigor'eva ME, Andreeva LA, Miasoedov NF

Izvestiia Akademii nauk. Seriia biologicheskaia1 Jul 2010Cited by 1 (Europe PMC)

PMID20799647 (opens in a new tab)PepBankPUB-20799647
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats under 60 min of immobilization stress, repeated intranasal semax prevented the hypercoagulation response and protected against enhanced blood coagulability.

    In plain wordsIn rats under stress, repeated nasal semax prevented the rise in blood clotting that stress caused.

    Peptide
    Semax
    Outcome
    DecreaseHypercoagulation response to prolonged immobilization stress
    Study

    ratn: not reported in source

    Acute immobilization stress
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    Dose not stated · intranasal · repeated injectionAs given in this study (rat).

    Source sentences

    Summary
    Our results showed that semax had a protective effect against enhanced blood coagulability resulting from repeated immobilization stress.
    1 context sentence
    Summary · context
    Repeated intranasal injection of each of these peptides to rats prior to acute immobilization stress prevented a hypercoagulation response to prolonged stress lasting 60 min.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats under stress, semax had an antistress protective effect that appeared as activation of the anticoagulation system.

    In plain wordsIn rats under stress, semax protected the body by switching on its anti-clotting system.

    Peptide
    Semax
    Outcome
    IncreaseAnticoagulation system activation
    Study

    ratn: not reported in source

    Acute immobilization stress
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    We discovered that simple proline-containing peptides Gly-Pro, Pro-Gly, Pro-Gly-Pro, and semax had an antistress protective effect on the organism appearing as anticoagulation system activation.

Studies that did not test the peptide alone4

In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Semax.

  1. 03AnimalNot a test of Semax aloneAnimal study (in vivo)Efficacy outcome

    In rats under immobilization stress, the proline-containing peptides, semax among them, increased antithrombotic activity.

    In plain wordsIn rats under stress, a group of proline peptides including semax raised the body's anti-clot activity.

    Peptide
    Semax
    Outcome
    IncreaseAntithrombotic activity (pooled peptides)
    Study

    ratn: not reported in source

    Acute immobilization stress
    Outcome group
    Bleeding and clotting · Cardiovascular

    Source sentences

    Summary
    At the same time there was increase of antithrombotic, anticoagulant, and fibrin depolymerization activity and recovery of enzymatic fibrinolytic activity.

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

  2. 04AnimalNot a test of Semax aloneAnimal study (in vivo)Efficacy outcome

    In rats under immobilization stress, the proline-containing peptides, semax among them, increased anticoagulant activity.

    In plain wordsIn rats under stress, a group of proline peptides including semax raised the body's anti-clotting activity.

    Peptide
    Semax
    Outcome
    IncreaseAnticoagulant activity (pooled peptides)
    Study

    ratn: not reported in source

    Acute immobilization stress
    Outcome group
    Bleeding and clotting · Cardiovascular

    Source sentences

    Summary
    At the same time there was increase of antithrombotic, anticoagulant, and fibrin depolymerization activity and recovery of enzymatic fibrinolytic activity.

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

  3. 05AnimalNot a test of Semax aloneAnimal study (in vivo)Efficacy outcome

    In rats under immobilization stress, the proline-containing peptides, semax among them, increased fibrin depolymerization activity.

    In plain wordsIn rats under stress, a group of proline peptides including semax raised the body's ability to break up fibrin.

    Peptide
    Semax
    Outcome
    IncreaseFibrin depolymerization activity (pooled peptides)
    Study

    ratn: not reported in source

    Acute immobilization stress
    Outcome group
    Bleeding and clotting · Cardiovascular

    Source sentences

    Summary
    At the same time there was increase of antithrombotic, anticoagulant, and fibrin depolymerization activity and recovery of enzymatic fibrinolytic activity.

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

  4. 06AnimalNot a test of Semax aloneAnimal study (in vivo)Efficacy outcome

    In rats under immobilization stress, the proline-containing peptides, semax among them, restored enzymatic fibrinolytic activity.

    In plain wordsIn rats under stress, a group of proline peptides including semax restored the body's clot-dissolving enzyme activity.

    Peptide
    Semax
    Outcome
    IncreaseEnzymatic fibrinolytic activity (pooled peptides)
    Study

    ratn: not reported in source

    Acute immobilization stress
    Outcome group
    Bleeding and clotting · Cardiovascular

    Source sentences

    Summary
    At the same time there was increase of antithrombotic, anticoagulant, and fibrin depolymerization activity and recovery of enzymatic fibrinolytic activity.

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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