In human and guinea pig isolated airway preparations, the VPAC2 agonist RO5024118 was significantly more potent than native VIP at inducing bronchodilation; native VIP was the comparator.
In plain wordsIn lab tests on airway tissue, the VIP-derived drug RO5024118 relaxed airways at lower doses than natural VIP did.
- Outcome
- Not applicableBronchodilator potency of RO5024118 versus native VIP
- Study
human, guinea pign: not reported in source
isolated airway smooth muscle preparations- Comparator
- Native VIP
- Outcome group
- Receptor activity and mechanism · Respiratory
Source sentences
In human and guinea pig isolated airway preparations, RO5024118 induced bronchodilatory effects comparable with RO0251553 and the long-acting β-agonist salmeterol and was significantly more potent than native vasoactive intestinal peptide and the short-acting β-agonist salbutamol.
1 context sentence(design, population, supporting numbers)
Bronchodilatory activity of RO5024118 was investigated in guinea pig and human isolated airway smooth muscle preparations and in a guinea pig bronchoconstriction model.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).