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Study · Measured the body's own peptide · 2010

2 results

Effects of combined hormone replacement therapy or its effective agents on the IGF-1 pathway in skeletal muscle.

Pöllänen E, Ronkainen PH, Horttanainen M, Takala T, Puolakka J, Suominen H, Sipilä S, Kovanen V

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society17 Aug 2010Cited by 39 (Europe PMC)

PMID20724185 (opens in a new tab)DOI10.1016/j.ghir.2010.07.003 (opens in a new tab)PepBankPUB-20724185
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialMechanism

    In postmenopausal women, year-long hormone replacement therapy increased natural IGF-1Ec (MGF) gene expression in muscle compared with placebo.

    In plain wordsIn women after menopause, a year of hormone therapy raised the body's own MGF gene activity in muscle compared with placebo.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseIGF-1Ec (MGF) gene expression in muscle
    Study

    n = 19

    Comparator
    Placebo
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    The gene expression of IGF-1 and its splice variant, IGF-1Ec (also known as the mechano growth factor or MGF), mTOR, FOXO3, and AR was up-regulated among the HRT users compared to the CO (P<0.05)
    2 context sentences
    Summary · context
    To examine the effects of HRT on skeletal muscle in vivo, we utilized pre- and post-intervention samples from a randomized double blinded trial with 50-57-year-old women.
    Summary · context
    The intervention included the year-long use of either HRT preparation (2 mg 17β-estradiol, E₂; 1mg norethisterone acetate, NETA, n=10) or placebo (CO, n=9).

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialMechanism

    In postmenopausal women, the change in natural IGF-1Ec (MGF) transcript level correlated positively with muscle size at post-intervention (r=0.5).

    In plain wordsIn women after menopause, a bigger rise in the body's own MGF gene activity was linked to larger muscle size.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableCorrelation of IGF-1Ec transcript change with muscle size
    Study

    n: not reported in source

    Outcome group
    Muscle injury and repair · Musculoskeletal

    Measurements

    correlation r
    0.5 r
    IGF-1Ec change vs muscle size

    Source sentences

    Summary
    The change in the level of IGF-1Ec transcript correlated positively with muscle size at post-intervention (r=0.5, P<0.05).
    2 context sentences
    Summary · context
    To examine the effects of HRT on skeletal muscle in vivo, we utilized pre- and post-intervention samples from a randomized double blinded trial with 50-57-year-old women.
    Summary · context
    The intervention included the year-long use of either HRT preparation (2 mg 17β-estradiol, E₂; 1mg norethisterone acetate, NETA, n=10) or placebo (CO, n=9).

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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