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Study · Animal study (in vivo) · rat · 2010

3 results

Sustained delivery of human growth hormone using a polyelectrolyte complex-loaded thermosensitive polyphosphazene hydrogel.

Park MR, Chun C, Ahn SW, Ki MH, Cho CS, Song SC

Journal of controlled release : official journal of the Controlled Release Society14 Aug 2010Cited by 51 (Europe PMC)

PMID20713099 (opens in a new tab)DOI10.1016/j.jconrel.2010.07.126 (opens in a new tab)PepBankPUB-20713099
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, a single administration of PEC-loaded hydrogel sustained hGH release for 5 days.

    In plain wordsIn rats, one administration of PEC-loaded hydrogel sustained hGH release for 5 days.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableSustained hGH release
    Study

    ratn: not reported in source

    hGH delivery model
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Sustained release duration
    5 days
    single administration

    Source sentences

    Summary
    In a pharmacokinetic study in rats, a single administration of PEC-loaded hydrogel resulted in the sustained release of hGH for 5days.
    1 context sentence
    Summary · context
    PEC was prepared by mixing polycations with hGH to suppress diffusion of hGH from the hydrogel through an enlargement of the hydrodynamic size of hGH.

Studies that did not test the peptide alone2

In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking HGH (somatotropin).

  1. 02AnimalNot a test of HGH (somatotropin) aloneAnimal study (in vivo)Pharmacokinetics

    In animals, increasing PLA in the hGH-containing PEC-loaded hydrogel decreased the initial hGH release rate.

    In plain wordsIn animals, more PLA in the hGH-containing PEC-loaded hydrogel reduced the initial hGH release rate.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseInitial hGH release rate in vivo
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    PLA decreased the initial release rate of hGH in proportion to the amount of PLA in vitro and in vivo.
    1 context sentence
    Summary · context
    PEC was prepared by mixing polycations with hGH to suppress diffusion of hGH from the hydrogel through an enlargement of the hydrodynamic size of hGH.

    In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking HGH (somatotropin).

  2. 03AnimalNot a test of HGH (somatotropin) aloneAnimal study (in vivo)Pharmacokinetics

    In animals, zinc increased the amount of hGH released from the PEC-loaded hydrogel.

    In plain wordsIn animals, zinc increased the amount of hGH released from the PEC-loaded hydrogel.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseReleased hGH amount in vivo
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Zinc increased the released amount of hGH from the PEC-loaded hydrogel in vitro and in vivo.
    1 context sentence
    Summary · context
    PEC was prepared by mixing polycations with hGH to suppress diffusion of hGH from the hydrogel through an enlargement of the hydrodynamic size of hGH.

    In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking HGH (somatotropin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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