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Study · Ex vivo tissue · 2010

3 results

Human skin retention and penetration of a copper tripeptide in vitro as function of skin layer towards anti-inflammatory therapy.

Hostynek JJ, Dreher F, Maibach HI

Inflammation research : official journal of the European Histamine Research Society ... [et al.]13 Aug 2010Cited by 12 (Europe PMC)

PMID20703511 (opens in a new tab)PMCIDPMC2945467 (opens in a new tab)DOI10.1007/s00011-010-0214-4 (opens in a new tab)PepBankPUB-20703511
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissuePharmacokinetics

    The permeability coefficient of the copper tripeptide through dermatomed human skin was 2.43 x 10^-4 cm/h.

    In plain wordsIn lab tests on human skin, the copper tripeptide crossed the skin at a measurable rate.

    Peptide
    GHK-Cu
    Outcome
    Not applicablePermeability coefficient through dermatomed skin
    Study

    humann: not reported in source

    dermatomed human skin in flow-through diffusion cells
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    0.68% aq. · transdermal · 48 hAs given in this study (human).

    Measurements

    Permeability coefficient
    2.43 x10^-4 cm/h
    dermatomed skin

    Source sentences

    Summary
    The permeability coefficient of the compound through dermatomed skin was 2.43 ± 0.51 × 10(-4) cm/h; 136.2 ± 17.5 μg/cm(2) copper permeated 1 cm(2) of that tissue over 48 h, while 82 ± 8.1 μg/cm(2) of copper were retained there as depot.
    2 context sentences
    Summary · context
    0.68% aq. Copper as a tripeptide was applied on isolated stratum corneum, on heat-separated epidermis and on dermatomed skin.
    Summary · context
    Receptor fluid collected over 48 h in 4 h intervals was analyzed by inductively coupled plasma mass spectrometry for copper in tissues and receptor fluid.
  2. 02LabEx vivo tissuePharmacokinetics

    Over 48 h, 136.2 μg/cm2 of copper permeated dermatomed human skin after application of the copper tripeptide.

    In plain wordsIn lab tests on human skin, copper from the copper tripeptide passed through the skin over 48 hours.

    Peptide
    GHK-Cu
    Outcome
    Not applicableCopper permeation over 48 h
    Study

    humann: not reported in source

    dermatomed human skin in flow-through diffusion cells
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    0.68% aq. · transdermal · 48 hAs given in this study (human).

    Measurements

    Copper permeated
    136.2 μg/cm2
    dermatomed skin, 48 h

    Source sentences

    Summary
    The permeability coefficient of the compound through dermatomed skin was 2.43 ± 0.51 × 10(-4) cm/h; 136.2 ± 17.5 μg/cm(2) copper permeated 1 cm(2) of that tissue over 48 h, while 82 ± 8.1 μg/cm(2) of copper were retained there as depot.
    2 context sentences
    Summary · context
    0.68% aq. Copper as a tripeptide was applied on isolated stratum corneum, on heat-separated epidermis and on dermatomed skin.
    Summary · context
    Receptor fluid collected over 48 h in 4 h intervals was analyzed by inductively coupled plasma mass spectrometry for copper in tissues and receptor fluid.
  3. 03LabEx vivo tissuePharmacokinetics

    Over 48 h, 82 μg/cm2 of copper was retained as a depot in dermatomed human skin after application of the copper tripeptide.

    In plain wordsIn lab tests on human skin, some copper from the copper tripeptide stayed in the skin as a store.

    Peptide
    GHK-Cu
    Outcome
    Not applicableCopper retained in skin
    Study

    humann: not reported in source

    dermatomed human skin in flow-through diffusion cells
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    0.68% aq. · transdermal · 48 hAs given in this study (human).

    Measurements

    Copper retained
    82 μg/cm2
    dermatomed skin, 48 h

    Source sentences

    Summary
    The permeability coefficient of the compound through dermatomed skin was 2.43 ± 0.51 × 10(-4) cm/h; 136.2 ± 17.5 μg/cm(2) copper permeated 1 cm(2) of that tissue over 48 h, while 82 ± 8.1 μg/cm(2) of copper were retained there as depot.
    2 context sentences
    Summary · context
    0.68% aq. Copper as a tripeptide was applied on isolated stratum corneum, on heat-separated epidermis and on dermatomed skin.
    Summary · context
    Receptor fluid collected over 48 h in 4 h intervals was analyzed by inductively coupled plasma mass spectrometry for copper in tissues and receptor fluid.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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