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Study · Randomized controlled trial · n = 74 · 2010

2 results

Acute effects of intranasal oxytocin on subjective and behavioral responses to social rejection.

Alvares GA, Hickie IB, Guastella AJ

Experimental and clinical psychopharmacology1 Aug 2010Cited by 64 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy adults, intranasal oxytocin did not change the negative affective and attachment-related reactions to social rejection in ostracized participants.

    In plain wordsIn healthy adults, nose-spray oxytocin did not change the negative feelings that came with being left out of a game.

    Peptide
    Oxytocin
    Outcome
    No significant changeAffective and attachment reactions to ostracism
    Study

    n = 74

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Ostracized participants reported negative affective and attachment-related reactions, as well as a significant motivational change in increased desire to be involved in the game; these effects were not influenced by oxytocin.
    2 context sentences
    Summary · context
    The results suggest that in an explicitly aversive context, oxytocin does not buffer against the immediate impact of blunt social rejection.
    Summary · context
    In a double-blind, randomized, between-subjects design, 74 healthy male and female participants were administered intranasal oxytocin or placebo and subsequently ostracized or included during this virtual ball-tossing game.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy adults, intranasal oxytocin increased the desire of included participants to play again with the same participants.

    In plain wordsIn healthy adults, nose-spray oxytocin increased the wish of included players to play again with the same people.

    Peptide
    Oxytocin
    Outcome
    IncreaseIncluded participants' desire to play again
    Study

    n = 74

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Intranasal oxytocin did, however, increase included participants' desire to play again with the same participants, suggesting oxytocin enhanced desire for future social engagement following inclusion.
    1 context sentence
    Summary · context
    In a double-blind, randomized, between-subjects design, 74 healthy male and female participants were administered intranasal oxytocin or placebo and subsequently ostracized or included during this virtual ball-tossing game.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 1NCT03060031

Effects of Intranasal Oxytocin Administration on Social Influence Effects on Pain

University of Colorado, Bouldern = 5121 Jun 2017 to 1 Apr 2019

Pain

Trial pageClinicalTrials.govUpdated 25 Jun 2019

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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