In osteoporotic women, teriparatide increased cancellous mineralization heterogeneity by 10.7% from baseline.
In plain wordsIn women with osteoporosis, teriparatide increased cancellous mineralization variation from baseline.
- Peptide
- Teriparatide (PTH 1-34)
- Outcome
- IncreasePooled cancellous mineralization heterogeneity
- Study
n = 16
- Comparator
- Baseline
- Outcome group
- Bone and joint · Musculoskeletal
- Studied dose
- Dose not stated · 12 monthsAs given in this study (human).
Measurements
- Cancellous mineralization heterogeneity change (Cn.Ca(Width))
- 10.7%
- pooled groups, change from baseline
Source sentences
The pooled groups revealed increased Cn.Ca(Width) and Ct.Ca(Width) (+10.7%, p < .01, and +19.6%, p < .001, respectively) as well as increased Cn.Ca(Low) and Ct.Ca(Low) (+18.2%, p < .05, and +36.6%, p < .01, respectively).
1 context sentence(design, population, supporting numbers)
We studied paired transiliac bone biopsy samples taken before and after 1 year of treatment with recombinant human parathyroid hormone peptide 1-34 (teriparatide) from 16 osteoporotic women treated with either alendronate (priorALN) or risedronate (priorRIS) for at least 2 years and subsequently tre…