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Study · Non-randomized trial · n = 16 · 2010

10 results

Effects of 1 year of daily teriparatide treatment on iliacal bone mineralization density distribution (BMDD) in postmenopausal osteoporotic women previously treated with alendronate or risedronate.

Misof BM, Paschalis EP, Blouin S, Fratzl-Zelman N, Klaushofer K, Roschger P

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research1 Nov 2010Cited by 29 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

9 results from studies that gave the peptide. 9 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In osteoporotic women, teriparatide increased cancellous mineralization heterogeneity by 10.7% from baseline.

    In plain wordsIn women with osteoporosis, teriparatide increased cancellous mineralization variation from baseline.

    Outcome
    IncreasePooled cancellous mineralization heterogeneity
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Measurements

    Cancellous mineralization heterogeneity change (Cn.Ca(Width))
    10.7%
    pooled groups, change from baseline

    Source sentences

    Summary
    The pooled groups revealed increased Cn.Ca(Width) and Ct.Ca(Width) (+10.7%, p < .01, and +19.6%, p < .001, respectively) as well as increased Cn.Ca(Low) and Ct.Ca(Low) (+18.2%, p < .05, and +36.6%, p < .01, respectively).
    1 context sentence
    Summary · context
    We studied paired transiliac bone biopsy samples taken before and after 1 year of treatment with recombinant human parathyroid hormone peptide 1-34 (teriparatide) from 16 osteoporotic women treated with either alendronate (priorALN) or risedronate (priorRIS) for at least 2 years and subsequently tre…
  2. 02HumanNon-randomized trialEfficacy outcome

    In osteoporotic women, teriparatide increased cortical mineralization heterogeneity by 19.6% from baseline.

    In plain wordsIn women with osteoporosis, teriparatide increased cortical mineralization variation from baseline.

    Outcome
    IncreasePooled cortical mineralization heterogeneity
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Measurements

    Cortical mineralization heterogeneity change (Ct.Ca(Width))
    19.6%
    pooled groups, change from baseline

    Source sentences

    Summary
    The pooled groups revealed increased Cn.Ca(Width) and Ct.Ca(Width) (+10.7%, p < .01, and +19.6%, p < .001, respectively) as well as increased Cn.Ca(Low) and Ct.Ca(Low) (+18.2%, p < .05, and +36.6%, p < .01, respectively).
    1 context sentence
    Summary · context
    We studied paired transiliac bone biopsy samples taken before and after 1 year of treatment with recombinant human parathyroid hormone peptide 1-34 (teriparatide) from 16 osteoporotic women treated with either alendronate (priorALN) or risedronate (priorRIS) for at least 2 years and subsequently tre…
  3. 03HumanNon-randomized trialEfficacy outcome

    In osteoporotic women, teriparatide increased cancellous low-mineralized bone area by 18.2% from baseline.

    In plain wordsIn women with osteoporosis, teriparatide increased cancellous low-mineralized bone area from baseline.

    Outcome
    IncreasePooled cancellous low-mineralized area
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Measurements

    Change in pooled cancellous low-mineralized bone area (Cn.Ca(Low)) from baseline
    18.2%
    Pooled priorALN and priorRIS women, 12 months of teriparatide

    Source sentences

    Summary
    The pooled groups revealed increased Cn.Ca(Width) and Ct.Ca(Width) (+10.7%, p < .01, and +19.6%, p < .001, respectively) as well as increased Cn.Ca(Low) and Ct.Ca(Low) (+18.2%, p < .05, and +36.6%, p < .01, respectively).
    1 context sentence
    Summary · context
    We studied paired transiliac bone biopsy samples taken before and after 1 year of treatment with recombinant human parathyroid hormone peptide 1-34 (teriparatide) from 16 osteoporotic women treated with either alendronate (priorALN) or risedronate (priorRIS) for at least 2 years and subsequently tre…
  4. 04HumanNon-randomized trialEfficacy outcome

    In osteoporotic women, teriparatide increased cortical low-mineralized bone area by 36.6% from baseline.

    In plain wordsIn women with osteoporosis, teriparatide increased cortical low-mineralized bone area from baseline.

    Outcome
    IncreasePooled cortical low-mineralized area
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Measurements

    Change in pooled cortical low-mineralized bone area (Ct.Ca(Low)) from baseline
    36.6%
    Pooled priorALN and priorRIS women, 12 months of teriparatide

    Source sentences

    Summary
    The pooled groups revealed increased Cn.Ca(Width) and Ct.Ca(Width) (+10.7%, p < .01, and +19.6%, p < .001, respectively) as well as increased Cn.Ca(Low) and Ct.Ca(Low) (+18.2%, p < .05, and +36.6%, p < .01, respectively).
    1 context sentence
    Summary · context
    We studied paired transiliac bone biopsy samples taken before and after 1 year of treatment with recombinant human parathyroid hormone peptide 1-34 (teriparatide) from 16 osteoporotic women treated with either alendronate (priorALN) or risedronate (priorRIS) for at least 2 years and subsequently tre…
  5. 05HumanNon-randomized trialEfficacy outcome

    In women previously given alendronate, teriparatide increased cancellous low-mineralized bone area by 25.9% from baseline.

    In plain wordsIn women previously given alendronate, teriparatide increased cancellous low-mineralized bone area from baseline.

    Outcome
    IncreaseCancellous low-mineralized area, priorALN
    Study

    n: not reported in source

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Measurements

    Cancellous low-mineralized area change (Cn.Ca(Low))
    25.9%
    priorALN, change from baseline

    Source sentences

    Summary
    Analyzing changes from baseline for each bisphosphonate group separately, priorALN patients revealed increases in the portion of low mineralized bone areas (Cn.Ca(Low) +25.9%, Ct.Ca(Low) +62.0%, both p < .05) and Ct. heterogeneity of mineralization (Ct.Ca(Width) +22.8%, p < .001).
    1 context sentence
    Summary · context
    We studied paired transiliac bone biopsy samples taken before and after 1 year of treatment with recombinant human parathyroid hormone peptide 1-34 (teriparatide) from 16 osteoporotic women treated with either alendronate (priorALN) or risedronate (priorRIS) for at least 2 years and subsequently tre…
  6. 06HumanNon-randomized trialEfficacy outcome

    In women previously given alendronate, teriparatide increased cortical low-mineralized bone area by 62.0% from baseline.

    In plain wordsIn women previously given alendronate, teriparatide increased cortical low-mineralized bone area from baseline.

    Outcome
    IncreaseCortical low-mineralized area, priorALN
    Study

    n: not reported in source

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Measurements

    Cortical low-mineralized area change (Ct.Ca(Low))
    62%
    priorALN, change from baseline

    Source sentences

    Summary
    Analyzing changes from baseline for each bisphosphonate group separately, priorALN patients revealed increases in the portion of low mineralized bone areas (Cn.Ca(Low) +25.9%, Ct.Ca(Low) +62.0%, both p < .05) and Ct. heterogeneity of mineralization (Ct.Ca(Width) +22.8%, p < .001).
    1 context sentence
    Summary · context
    We studied paired transiliac bone biopsy samples taken before and after 1 year of treatment with recombinant human parathyroid hormone peptide 1-34 (teriparatide) from 16 osteoporotic women treated with either alendronate (priorALN) or risedronate (priorRIS) for at least 2 years and subsequently tre…
  7. 07HumanNon-randomized trialEfficacy outcome

    In women previously given alendronate, teriparatide increased cortical mineralization heterogeneity by 22.8% from baseline.

    In plain wordsIn women previously given alendronate, teriparatide increased cortical mineralization variation from baseline.

    Outcome
    IncreaseCortical mineralization heterogeneity, priorALN
    Study

    n: not reported in source

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Measurements

    Cortical mineralization heterogeneity change (Ct.Ca(Width))
    22.8%
    priorALN, change from baseline

    Source sentences

    Summary
    Analyzing changes from baseline for each bisphosphonate group separately, priorALN patients revealed increases in the portion of low mineralized bone areas (Cn.Ca(Low) +25.9%, Ct.Ca(Low) +62.0%, both p < .05) and Ct. heterogeneity of mineralization (Ct.Ca(Width) +22.8%, p < .001).
    1 context sentence
    Summary · context
    We studied paired transiliac bone biopsy samples taken before and after 1 year of treatment with recombinant human parathyroid hormone peptide 1-34 (teriparatide) from 16 osteoporotic women treated with either alendronate (priorALN) or risedronate (priorRIS) for at least 2 years and subsequently tre…
  8. 08HumanNon-randomized trialEfficacy outcome

    In women previously given risedronate, teriparatide increased cancellous mineralization heterogeneity by 14.8% from baseline.

    In plain wordsIn women previously given risedronate, teriparatide increased cancellous mineralization variation from baseline.

    Outcome
    IncreaseCancellous mineralization heterogeneity, priorRIS
    Study

    n: not reported in source

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Measurements

    Cancellous mineralization heterogeneity change (Cn.Ca(Width))
    14.8%
    priorRIS, change from baseline

    Source sentences

    Summary
    PriorRIS patients showed increased mineralization heterogeneity (Cn.Ca(Width) +14.8%, p < .05, and Ct.Ca(Width) +15.8%, p < .001).
    1 context sentence
    Summary · context
    We studied paired transiliac bone biopsy samples taken before and after 1 year of treatment with recombinant human parathyroid hormone peptide 1-34 (teriparatide) from 16 osteoporotic women treated with either alendronate (priorALN) or risedronate (priorRIS) for at least 2 years and subsequently tre…
  9. 09HumanNon-randomized trialEfficacy outcome

    In women previously given risedronate, teriparatide increased cortical mineralization heterogeneity by 15.8% from baseline.

    In plain wordsIn women previously given risedronate, teriparatide increased cortical mineralization variation from baseline.

    Outcome
    IncreaseCortical mineralization heterogeneity, priorRIS
    Study

    n: not reported in source

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Measurements

    Cortical mineralization heterogeneity change (Ct.Ca(Width))
    15.8%
    priorRIS, change from baseline

    Source sentences

    Summary
    PriorRIS patients showed increased mineralization heterogeneity (Cn.Ca(Width) +14.8%, p < .05, and Ct.Ca(Width) +15.8%, p < .001).
    1 context sentence
    Summary · context
    We studied paired transiliac bone biopsy samples taken before and after 1 year of treatment with recombinant human parathyroid hormone peptide 1-34 (teriparatide) from 16 osteoporotic women treated with either alendronate (priorALN) or risedronate (priorRIS) for at least 2 years and subsequently tre…

Studies that did not test the peptide alone1

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

  1. 10HumanNot a test of Teriparatide (PTH 1-34) aloneObservational studyEfficacy outcome

    In osteoporotic women, the mineralization response to teriparatide did not depend on the prior bisphosphonate type.

    In plain wordsIn women with osteoporosis, the bone mineralization response to teriparatide did not depend on the prior bisphosphonate type.

    Outcome
    No significant changeBMDD response by prior bisphosphonate
    Study

    n = 16

    Comparator
    Prior alendronate versus prior risedronate
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Analysis of the influence of the prior bisphosphonate treatment showed that the BMDD response to 1 year of teriparatide treatment did not depend on the type of prior bisphosphonate.
    1 context sentence
    Summary · context
    We studied paired transiliac bone biopsy samples taken before and after 1 year of treatment with recombinant human parathyroid hormone peptide 1-34 (teriparatide) from 16 osteoporotic women treated with either alendronate (priorALN) or risedronate (priorRIS) for at least 2 years and subsequently tre…

    In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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