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Study · Animal study (in vivo) · horse · 2000

3 results

Oxytocin and PGF2alpha release in mares resistant and susceptible to persistent mating-induced endometritis.

Nikolakopoulos E, Kindahl H, Watson ED

Journal of reproduction and fertility. Supplement1 Jan 2000Cited by 1 (Europe PMC)

PMID20681148 (opens in a new tab)PepBankPUB-20681148
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In oestrous mares, intravenous oxytocin caused significantly greater PGF2alpha release in resistant than in susceptible mares.

    In plain wordsIn mares, oxytocin caused a larger prostaglandin release in resistant mares than in susceptible mares.

    Peptide
    Oxytocin
    Outcome
    MixedPGF2alpha release after intravenous oxytocin, resistant versus susceptible mares
    Study

    horsen = 16

    Mares resistant or susceptible to persistent mating-induced endometritis
    Comparator
    Susceptible mares
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 iu per 20 kg body weight · intravenousAs given in this study (horse).

    Source sentences

    Summary
    Administration of exogenous oxytocin caused significantly greater PGF2alpha release in resistant than in susceptible mares.
    2 context sentences
    Summary · context
    In a second experiment, an i.v. injection of oxytocin (1 iu per 20 kg body weight) was administered to both resistant and susceptible oestrous mares.
    Summary · context
    Mares resistant (n=7) and susceptible (n=9) to persistent mating-induced endometritis were artificially inseminated (AI) during oestrus with chilled extended semen.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In resistant and susceptible mares, artificial insemination significantly increased the body's own plasma oxytocin concentrations.

    In plain wordsIn mares, insemination raised the body's own oxytocin in blood in both groups.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after artificial insemination
    Study

    horsen = 16

    Mares resistant or susceptible to persistent mating-induced endometritis
    Outcome group
    Hormone levels · Reproductive and sexual health

    Source sentences

    Summary
    AI caused a significant increase in oxytocin concentrations in both the resistant and susceptible mares
    1 context sentence
    Summary · context
    Mares resistant (n=7) and susceptible (n=9) to persistent mating-induced endometritis were artificially inseminated (AI) during oestrus with chilled extended semen.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In mares, the oxytocin release after artificial insemination did not differ significantly between resistant and susceptible mares.

    In plain wordsIn mares, the body's own oxytocin rise after insemination was similar in resistant and susceptible mares.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma oxytocin release after insemination, resistant versus susceptible mares
    Study

    horsen = 16

    Mares resistant or susceptible to persistent mating-induced endometritis
    Comparator
    Susceptible mares
    Outcome group
    Hormone levels · Reproductive and sexual health

    Source sentences

    Summary
    there was no significant difference in oxytocin release between the two groups of mares.
    1 context sentence
    Summary · context
    Mares resistant (n=7) and susceptible (n=9) to persistent mating-induced endometritis were artificially inseminated (AI) during oestrus with chilled extended semen.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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