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Study · Measured the body's own peptide · 2010

3 results

IGF-1 splice variant and IGF-1 peptide expression patterns in young and old human skeletal muscle prior to and following sequential exercise bouts.

Roberts MD, Dalbo VJ, Sunderland KL, Poole CN, Hassell SE, Bemben D, Cramer J, Stout J, Kerksick CM

European journal of applied physiology29 Jul 2010Cited by 17 (Europe PMC)

PMID20668872 (opens in a new tab)DOI10.1007/s00421-010-1588-2 (opens in a new tab)PepBankPUB-20668872
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialMechanism

    In younger and older men, baseline natural MGF mRNA expression in vastus lateralis muscle did not differ between age groups.

    In plain wordsBefore exercise, younger and older men had similar levels of the body's own MGF mRNA in muscle.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeBaseline MGF mRNA by age group
    Study

    n = 20

    Comparator
    Older versus younger men
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    There were no baseline differences in MGF or IGF-1EA mRNA expression and IGF-1 peptides between age groups.
    1 context sentence
    Summary · context
    Ten younger (18-25 years) and 10 older (60-75 years) males completed three sequential workouts (M, W, F) consisting of nine sets of lower body exercises with ten repetitions per set at an intensity of 80% of one repetition maximum.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelNon-randomized trialMechanism

    In older men, natural MGF mRNA expression in muscle rose at T2 to T4 relative to baseline during three sequential resistance workouts.

    In plain wordsIn older men, three weight-training workouts raised the body's own MGF mRNA in muscle compared with before training.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF mRNA after sequential resistance workouts in older men
    Study

    n = 10

    Comparator
    Baseline
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    MGF expression increased at T2-T4 in the older group relative to baseline values (p < 0.05)
    1 context sentence
    Summary · context
    Ten younger (18-25 years) and 10 older (60-75 years) males completed three sequential workouts (M, W, F) consisting of nine sets of lower body exercises with ten repetitions per set at an intensity of 80% of one repetition maximum.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelNon-randomized trialMechanism

    In younger men, repeated resistance exercise bouts did not raise natural MGF mRNA in muscle. The increase occurred only in older men.

    In plain wordsIn younger men, three weight-training workouts did not raise the body's own MGF mRNA in muscle. Only older men showed a rise.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeMGF mRNA after sequential resistance workouts in younger men
    Study

    n = 10

    Comparator
    Baseline
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    Repeated conventional exercise bouts resulted in a summative increase in MGF mRNA expression only in older individuals
    1 context sentence
    Summary · context
    Ten younger (18-25 years) and 10 older (60-75 years) males completed three sequential workouts (M, W, F) consisting of nine sets of lower body exercises with ten repetitions per set at an intensity of 80% of one repetition maximum.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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