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Study · Animal study (in vivo) · rat · 2010

12 results

Enhanced bone morphogenetic protein-2-induced ectopic and orthotopic bone formation by intermittent parathyroid hormone (1-34) administration.

Kempen DH, Lu L, Hefferan TE, Creemers LB, Heijink A, Maran A, Dhert WJ, Yaszemski MJ

Tissue engineering. Part A9 Sept 2010Cited by 30 (Europe PMC)

PMID20666615 (opens in a new tab)PMCIDPMC2991197 (opens in a new tab)DOI10.1089/ten.tea.2010.0173 (opens in a new tab)PepBankPUB-20666615
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, adding PTH (1-34) increased BMD in ectopic BMP-2 composites versus BMP-2 composites without PTH.

    In plain wordsIn rats, adding PTH increased bone density in ectopic BMP-2 implants compared with BMP-2 implants without PTH.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseEctopic BMP-2 composite BMD
    Study

    ratsn: not reported in source

    Ectopic implants and femoral defects
    Comparator
    BMP-2 composite without PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rats).

    Source sentences

    Summary
    Additional treatment of the rats with PTH (1-34) resulted in significantly (p < 0.05) enhanced BMD and bone volume in the BMP-2 composites at both implantation sites.
    4 context sentences
    Summary · context
    Empty or BMP-2-loaded poly(lactic-co glycolic acid)/poly(propylene fumarate)/gelatin composites were implanted subcutaneously and in femoral defects in rats (n = 9).
    Summary · context
    For the orthotopic site, empty defects were also tested.
    Summary · context
    Each of the conditions was investigated in combination with daily administered subcutaneous PTH (1-34) injections in the neck.
    Summary · context
    After 8 weeks of implantation, bone mineral density (BMD) and bone volume were analyzed using microcomputed tomography and histology.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, adding PTH (1-34) increased BMD in orthotopic BMP-2 composites versus BMP-2 composites without PTH.

    In plain wordsIn rats, adding PTH increased bone density in femoral BMP-2 implants compared with BMP-2 implants without PTH.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseOrthotopic BMP-2 composite BMD
    Study

    ratsn: not reported in source

    Ectopic implants and femoral defects
    Comparator
    BMP-2 composite without PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rats).

    Source sentences

    Summary
    Additional treatment of the rats with PTH (1-34) resulted in significantly (p < 0.05) enhanced BMD and bone volume in the BMP-2 composites at both implantation sites.
    4 context sentences
    Summary · context
    Empty or BMP-2-loaded poly(lactic-co glycolic acid)/poly(propylene fumarate)/gelatin composites were implanted subcutaneously and in femoral defects in rats (n = 9).
    Summary · context
    For the orthotopic site, empty defects were also tested.
    Summary · context
    Each of the conditions was investigated in combination with daily administered subcutaneous PTH (1-34) injections in the neck.
    Summary · context
    After 8 weeks of implantation, bone mineral density (BMD) and bone volume were analyzed using microcomputed tomography and histology.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, adding PTH (1-34) increased bone volume in ectopic BMP-2 composites versus BMP-2 composites without PTH.

    In plain wordsIn rats, adding PTH increased bone volume in ectopic BMP-2 implants compared with BMP-2 implants without PTH.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseEctopic BMP-2 composite bone volume
    Study

    ratsn: not reported in source

    Ectopic implants and femoral defects
    Comparator
    BMP-2 composite without PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rats).

    Source sentences

    Summary
    Additional treatment of the rats with PTH (1-34) resulted in significantly (p < 0.05) enhanced BMD and bone volume in the BMP-2 composites at both implantation sites.
    4 context sentences
    Summary · context
    Empty or BMP-2-loaded poly(lactic-co glycolic acid)/poly(propylene fumarate)/gelatin composites were implanted subcutaneously and in femoral defects in rats (n = 9).
    Summary · context
    For the orthotopic site, empty defects were also tested.
    Summary · context
    Each of the conditions was investigated in combination with daily administered subcutaneous PTH (1-34) injections in the neck.
    Summary · context
    After 8 weeks of implantation, bone mineral density (BMD) and bone volume were analyzed using microcomputed tomography and histology.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, adding PTH (1-34) increased bone volume in orthotopic BMP-2 composites versus BMP-2 composites without PTH.

    In plain wordsIn rats, adding PTH increased bone volume in femoral BMP-2 implants compared with BMP-2 implants without PTH.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseOrthotopic BMP-2 composite bone volume
    Study

    ratsn: not reported in source

    Ectopic implants and femoral defects
    Comparator
    BMP-2 composite without PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rats).

    Source sentences

    Summary
    Additional treatment of the rats with PTH (1-34) resulted in significantly (p < 0.05) enhanced BMD and bone volume in the BMP-2 composites at both implantation sites.
    4 context sentences
    Summary · context
    Empty or BMP-2-loaded poly(lactic-co glycolic acid)/poly(propylene fumarate)/gelatin composites were implanted subcutaneously and in femoral defects in rats (n = 9).
    Summary · context
    For the orthotopic site, empty defects were also tested.
    Summary · context
    Each of the conditions was investigated in combination with daily administered subcutaneous PTH (1-34) injections in the neck.
    Summary · context
    After 8 weeks of implantation, bone mineral density (BMD) and bone volume were analyzed using microcomputed tomography and histology.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH (1-34) affected humerus BMD, but the abstract does not specify the direction.

    In plain wordsIn rats, PTH affected upper arm bone density. The abstract does not state the direction.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Direction not reportedHumerus BMD
    Study

    ratsn: not reported in source

    Ectopic implants and femoral defects
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rats).

    Source sentences

    Summary
    Despite its effect on BMD in the humerus and vertebra, PTH (1-34) treatment had no significant effect on BMD and bone volume in the empty femoral defects and the ectopically or orthotopically implanted empty composites.
    4 context sentences
    Summary · context
    Empty or BMP-2-loaded poly(lactic-co glycolic acid)/poly(propylene fumarate)/gelatin composites were implanted subcutaneously and in femoral defects in rats (n = 9).
    Summary · context
    For the orthotopic site, empty defects were also tested.
    Summary · context
    Each of the conditions was investigated in combination with daily administered subcutaneous PTH (1-34) injections in the neck.
    Summary · context
    After 8 weeks of implantation, bone mineral density (BMD) and bone volume were analyzed using microcomputed tomography and histology.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH (1-34) affected vertebral BMD, but the abstract does not specify the direction.

    In plain wordsIn rats, PTH affected vertebral bone density. The abstract does not state the direction.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Direction not reportedVertebral BMD
    Study

    ratsn: not reported in source

    Ectopic implants and femoral defects
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rats).

    Source sentences

    Summary
    Despite its effect on BMD in the humerus and vertebra, PTH (1-34) treatment had no significant effect on BMD and bone volume in the empty femoral defects and the ectopically or orthotopically implanted empty composites.
    4 context sentences
    Summary · context
    Empty or BMP-2-loaded poly(lactic-co glycolic acid)/poly(propylene fumarate)/gelatin composites were implanted subcutaneously and in femoral defects in rats (n = 9).
    Summary · context
    For the orthotopic site, empty defects were also tested.
    Summary · context
    Each of the conditions was investigated in combination with daily administered subcutaneous PTH (1-34) injections in the neck.
    Summary · context
    After 8 weeks of implantation, bone mineral density (BMD) and bone volume were analyzed using microcomputed tomography and histology.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH (1-34) did not significantly affect BMD in empty femoral defects versus defects without PTH.

    In plain wordsIn rats, PTH did not significantly change bone density in empty femoral defects compared with defects without PTH.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeEmpty femoral defect BMD
    Study

    ratsn: not reported in source

    Ectopic implants and femoral defects
    Comparator
    Empty femoral defects without PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rats).

    Source sentences

    Summary
    Despite its effect on BMD in the humerus and vertebra, PTH (1-34) treatment had no significant effect on BMD and bone volume in the empty femoral defects and the ectopically or orthotopically implanted empty composites.
    4 context sentences
    Summary · context
    Empty or BMP-2-loaded poly(lactic-co glycolic acid)/poly(propylene fumarate)/gelatin composites were implanted subcutaneously and in femoral defects in rats (n = 9).
    Summary · context
    For the orthotopic site, empty defects were also tested.
    Summary · context
    Each of the conditions was investigated in combination with daily administered subcutaneous PTH (1-34) injections in the neck.
    Summary · context
    After 8 weeks of implantation, bone mineral density (BMD) and bone volume were analyzed using microcomputed tomography and histology.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH (1-34) did not significantly affect bone volume in empty femoral defects versus defects without PTH.

    In plain wordsIn rats, PTH did not significantly change bone volume in empty femoral defects compared with defects without PTH.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeEmpty femoral defect bone volume
    Study

    ratsn: not reported in source

    Ectopic implants and femoral defects
    Comparator
    Empty femoral defects without PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rats).

    Source sentences

    Summary
    Despite its effect on BMD in the humerus and vertebra, PTH (1-34) treatment had no significant effect on BMD and bone volume in the empty femoral defects and the ectopically or orthotopically implanted empty composites.
    4 context sentences
    Summary · context
    Empty or BMP-2-loaded poly(lactic-co glycolic acid)/poly(propylene fumarate)/gelatin composites were implanted subcutaneously and in femoral defects in rats (n = 9).
    Summary · context
    For the orthotopic site, empty defects were also tested.
    Summary · context
    Each of the conditions was investigated in combination with daily administered subcutaneous PTH (1-34) injections in the neck.
    Summary · context
    After 8 weeks of implantation, bone mineral density (BMD) and bone volume were analyzed using microcomputed tomography and histology.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH (1-34) did not significantly affect BMD in ectopic empty composites versus composites without PTH.

    In plain wordsIn rats, PTH did not significantly change bone density in ectopic empty implants compared with implants without PTH.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeEctopic empty composite BMD
    Study

    ratsn: not reported in source

    Ectopic implants and femoral defects
    Comparator
    Ectopic empty composites without PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rats).

    Source sentences

    Summary
    Despite its effect on BMD in the humerus and vertebra, PTH (1-34) treatment had no significant effect on BMD and bone volume in the empty femoral defects and the ectopically or orthotopically implanted empty composites.
    4 context sentences
    Summary · context
    Empty or BMP-2-loaded poly(lactic-co glycolic acid)/poly(propylene fumarate)/gelatin composites were implanted subcutaneously and in femoral defects in rats (n = 9).
    Summary · context
    For the orthotopic site, empty defects were also tested.
    Summary · context
    Each of the conditions was investigated in combination with daily administered subcutaneous PTH (1-34) injections in the neck.
    Summary · context
    After 8 weeks of implantation, bone mineral density (BMD) and bone volume were analyzed using microcomputed tomography and histology.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH (1-34) did not significantly affect bone volume in ectopic empty composites versus composites without PTH.

    In plain wordsIn rats, PTH did not significantly change bone volume in ectopic empty implants compared with implants without PTH.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeEctopic empty composite bone volume
    Study

    ratsn: not reported in source

    Ectopic implants and femoral defects
    Comparator
    Ectopic empty composites without PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rats).

    Source sentences

    Summary
    Despite its effect on BMD in the humerus and vertebra, PTH (1-34) treatment had no significant effect on BMD and bone volume in the empty femoral defects and the ectopically or orthotopically implanted empty composites.
    4 context sentences
    Summary · context
    Empty or BMP-2-loaded poly(lactic-co glycolic acid)/poly(propylene fumarate)/gelatin composites were implanted subcutaneously and in femoral defects in rats (n = 9).
    Summary · context
    For the orthotopic site, empty defects were also tested.
    Summary · context
    Each of the conditions was investigated in combination with daily administered subcutaneous PTH (1-34) injections in the neck.
    Summary · context
    After 8 weeks of implantation, bone mineral density (BMD) and bone volume were analyzed using microcomputed tomography and histology.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH (1-34) did not significantly affect BMD in orthotopic empty composites versus composites without PTH.

    In plain wordsIn rats, PTH did not significantly change bone density in femoral empty implants compared with implants without PTH.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeOrthotopic empty composite BMD
    Study

    ratsn: not reported in source

    Ectopic implants and femoral defects
    Comparator
    Orthotopic empty composites without PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rats).

    Source sentences

    Summary
    Despite its effect on BMD in the humerus and vertebra, PTH (1-34) treatment had no significant effect on BMD and bone volume in the empty femoral defects and the ectopically or orthotopically implanted empty composites.
    4 context sentences
    Summary · context
    Empty or BMP-2-loaded poly(lactic-co glycolic acid)/poly(propylene fumarate)/gelatin composites were implanted subcutaneously and in femoral defects in rats (n = 9).
    Summary · context
    For the orthotopic site, empty defects were also tested.
    Summary · context
    Each of the conditions was investigated in combination with daily administered subcutaneous PTH (1-34) injections in the neck.
    Summary · context
    After 8 weeks of implantation, bone mineral density (BMD) and bone volume were analyzed using microcomputed tomography and histology.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH (1-34) did not significantly affect bone volume in orthotopic empty composites versus composites without PTH.

    In plain wordsIn rats, PTH did not significantly change bone volume in femoral empty implants compared with implants without PTH.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeOrthotopic empty composite bone volume
    Study

    ratsn: not reported in source

    Ectopic implants and femoral defects
    Comparator
    Orthotopic empty composites without PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rats).

    Source sentences

    Summary
    Despite its effect on BMD in the humerus and vertebra, PTH (1-34) treatment had no significant effect on BMD and bone volume in the empty femoral defects and the ectopically or orthotopically implanted empty composites.
    4 context sentences
    Summary · context
    Empty or BMP-2-loaded poly(lactic-co glycolic acid)/poly(propylene fumarate)/gelatin composites were implanted subcutaneously and in femoral defects in rats (n = 9).
    Summary · context
    For the orthotopic site, empty defects were also tested.
    Summary · context
    Each of the conditions was investigated in combination with daily administered subcutaneous PTH (1-34) injections in the neck.
    Summary · context
    After 8 weeks of implantation, bone mineral density (BMD) and bone volume were analyzed using microcomputed tomography and histology.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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