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Study · Measured the body's own peptide · 2011

4 results

Antimicrobial peptide hCAP-18/LL-37 protein and mRNA expressions in different periodontal diseases.

Türkoğlu O, Kandiloğlu G, Berdeli A, Emingil G, Atilla G

Oral diseases1 Jan 2011Cited by 30 (Europe PMC)

PMID20646232 (opens in a new tab)DOI10.1111/j.1601-0825.2010.01704.x (opens in a new tab)PepBankPUB-20646232
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In gingival tissue, immunostaining of hCAP-18/LL‑37 on infiltrating neutrophils was significantly higher in chronic periodontitis patients than in healthy controls.

    In plain wordsIn people with chronic gum disease, the body's own hCAP-18/LL‑37 in gum tissue was higher than in healthy people.

    Peptide
    LL-37
    Outcome
    IncreasehCAP-18/LL-37 immunostaining in gingival tissue, chronic periodontitis versus control
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Tissue samples of chronic periodontitis patients had significantly higher immunostaining of hCAP-18/LL-37 on neutrophils infiltrating in both epithelium and connective tissue compared with controls
    1 context sentence
    Summary · context
    Ten patients with generalized aggressive periodontitis, 10 patients with chronic periodontitis, and 10 healthy controls were included in this study.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In gingival tissue, hCAP-18/LL‑37 mRNA expression seemed to be upregulated in chronic periodontitis compared with controls.

    In plain wordsIn people with chronic gum disease, the body's own hCAP-18/LL‑37 messenger RNA seemed higher than in healthy people.

    Peptide
    LL-37
    Outcome
    IncreasehCAP-18/LL-37 mRNA in gingival tissue, chronic periodontitis versus control
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    hCAP-18/LL-37 mRNA expression levels in tissue samples of chronic periodontitis patients seemed to be upregulated compared with controls.
    1 context sentence
    Summary · context
    Ten patients with generalized aggressive periodontitis, 10 patients with chronic periodontitis, and 10 healthy controls were included in this study.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In generalized aggressive periodontitis, hCAP-18/LL‑37 mRNA was downregulated in two patients and slightly increased in one patient compared with controls.

    In plain wordsIn people with aggressive gum disease, the body's own hCAP-18/LL‑37 messenger RNA was lower in two patients and slightly higher in one, versus healthy people.

    Peptide
    LL-37
    Outcome
    MixedhCAP-18/LL-37 mRNA in gingival tissue, generalized aggressive periodontitis versus control
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    While two generalized aggressive periodontitis patients showed downregulated hCAP-18/LL-37 mRNA expression levels, one generalized aggressive periodontitis patient showed slightly increased hCAP-18/LL-37 mRNA level compared with controls.
    1 context sentence
    Summary · context
    Ten patients with generalized aggressive periodontitis, 10 patients with chronic periodontitis, and 10 healthy controls were included in this study.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyMechanism

    In gingival tissue, hCAP-18/LL‑37 was a product of neutrophils.

    In plain wordsIn gum tissue, the body's own hCAP-18/LL‑37 came from neutrophils, a type of white blood cell.

    Peptide
    LL-37
    Outcome
    Not applicableCellular source of hCAP-18/LL-37 in gingival tissue
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    This study demonstrated that hCAP-18/LL-37 was a product of neutrophils.
    1 context sentence
    Summary · context
    Ten patients with generalized aggressive periodontitis, 10 patients with chronic periodontitis, and 10 healthy controls were included in this study.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:58 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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