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Study · Measured the body's own peptide · 2010

2 results

Pattern of Fos expression in the brain induced by selective activation of somatostatin receptor 2 in rats.

Goebel M, Stengel A, Wang L, Coskun T, Alsina-Fernandez J, Rivier J, Taché Y

Brain research15 Jul 2010Cited by 12 (Europe PMC)

PMID20637739 (opens in a new tab)PMCIDPMC2935321 (opens in a new tab)DOI10.1016/j.brainres.2010.07.024 (opens in a new tab)PepBankPUB-20637739
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats, intracerebroventricular ODT8-SST activated 36% of oxytocin-immunoreactive neurons in the magnocellular paraventricular hypothalamic nucleus.

    In plain wordsIn rats, a somatostatin-like peptide injected into the brain switched on 36% of the body's own oxytocin-producing neurons in one hypothalamus region.

    Peptide
    Oxytocin
    Outcome
    IncreaseFos activation of oxytocin neurons in the paraventricular hypothalamic nucleus
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Measurements

    Oxytocin neurons activated
    36%
    mPVN, ODT8-SST

    Source sentences

    Summary
    ODT8-SST activates 36% of oxytocin, 63% of vasopressin and 79% of sst(2) immunoreactive neurons in the mPVN
    2 context sentences
    Summary · context
    To evaluate the pattern of neuronal activation induced by peptide sst receptor agonists, we assessed Fos-expression in rat brain after intracerebroventricular (i.c.v.) injection of a newly developed selective sst(2) agonist compared to the oligosomatostatin ODT8-SST, a pan-sst(1-5) agonist.
    Summary · context
    Ninety min after injection of vehicle (10 microl) or previously established maximal orexigenic dose of peptides (1 microg=1 nmol/rat), brains were assessed for Fos-immunohistochemistry and doublelabeling.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats, intracerebroventricular ODT8-SST activated 28% of oxytocin-immunoreactive neurons in the supraoptic nucleus.

    In plain wordsIn rats, a somatostatin-like peptide injected into the brain switched on 28% of the body's own oxytocin-producing neurons in a second hypothalamus region.

    Peptide
    Oxytocin
    Outcome
    IncreaseFos activation of oxytocin neurons in the supraoptic nucleus
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Measurements

    Oxytocin neurons activated
    28%
    SON, ODT8-SST

    Source sentences

    Summary
    Doublelabeling in the hypothalamus showed that ODT8-SST activates 36% of oxytocin, 63% of vasopressin and 79% of sst(2) immunoreactive neurons in the mPVN and 28%, 55% and 25% in the SON, respectively.
    2 context sentences
    Summary · context
    To evaluate the pattern of neuronal activation induced by peptide sst receptor agonists, we assessed Fos-expression in rat brain after intracerebroventricular (i.c.v.) injection of a newly developed selective sst(2) agonist compared to the oligosomatostatin ODT8-SST, a pan-sst(1-5) agonist.
    Summary · context
    Ninety min after injection of vehicle (10 microl) or previously established maximal orexigenic dose of peptides (1 microg=1 nmol/rat), brains were assessed for Fos-immunohistochemistry and doublelabeling.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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