Cerebrolysin treatment attenuates heat shock protein overexpression in the brain following heat stress: an experimental study using immunohistochemistry at light and electron microscopy in the rat.

Sharma HS, Muresanu D, Sharma A, Zimmermann-Meinzingen S

Annals of the New York Academy of Sciences1 Jun 2010Cited by 19 (Europe PMC)

PMID20633119DOI10.1111/j.1749-6632.2009.05330.xPepBankPUB-20633119

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In heat-stressed rats, Cerebrolysin pretreatment markedly attenuated hyperthermia to 39.48 +/- 0.23 degrees C versus heat stress without pretreatment.
In plain wordsIn heat-stressed rats, Cerebrolysin pretreatment reduced hyperthermia compared with heat stress without pretreatment.
Peptide
Cerebrolysin
Outcome
DecreaseHyperthermia
Study
ratn: not reported in source
Heat stress
Comparator
Heat stress without Cerebrolysin pretreatment
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 mL/kg · intravenousAs given in this study (rat).
Measurements
Temperature
39.48 degrees C
Cerebrolysin pretreatment
Source sentences
Summary
Pretreatment with Cerebrolysin (5 mL/kg, i.v.) 30 minutes before heat stress markedly attenuated hyperthermia (39.48 +/- 0.23 degrees C, P < 0.01) and the induction of HSP to all the brain regions examined.
1 context sentence(design, population, supporting numbers)
Summary · context
The possibility that overexpression of heat shock proteins (HSPs) in the CNS represents a neurodestructive signal following hyperthermia was examined in a rat model using a potent neuroprotective drug, Cerebrolysin (Ebewe Pharma, Austria).
Report a problemFND-2063311901
02AnimalAnimal study (in vivo)Mechanism
In heat-stressed rats, Cerebrolysin pretreatment markedly attenuated HSP induction in all examined brain regions versus heat stress without pretreatment.
In plain wordsIn heat-stressed rats, Cerebrolysin pretreatment reduced HSP induction in all examined brain regions compared with heat stress without pretreatment.
Peptide
Cerebrolysin
Outcome
DecreaseHSP induction
Study
ratn: not reported in source
Heat stress
Comparator
Heat stress without Cerebrolysin pretreatment
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
5 mL/kg · intravenousAs given in this study (rat).
Source sentences
Summary
Pretreatment with Cerebrolysin (5 mL/kg, i.v.) 30 minutes before heat stress markedly attenuated hyperthermia (39.48 +/- 0.23 degrees C, P < 0.01) and the induction of HSP to all the brain regions examined.
1 context sentence(design, population, supporting numbers)
Summary · context
The possibility that overexpression of heat shock proteins (HSPs) in the CNS represents a neurodestructive signal following hyperthermia was examined in a rat model using a potent neuroprotective drug, Cerebrolysin (Ebewe Pharma, Austria).
Report a problemFND-2063311902
03AnimalAnimal study (in vivo)Efficacy outcome
In heat-stressed rats, Cerebrolysin pretreatment markedly reduced Evans blue albumin leakage versus heat stress without pretreatment.
In plain wordsIn heat-stressed rats, Cerebrolysin pretreatment reduced Evans blue albumin leakage compared with heat stress without pretreatment.
Peptide
Cerebrolysin
Outcome
DecreaseEvans blue albumin leakage
Study
ratn: not reported in source
Heat stress
Comparator
Heat stress without Cerebrolysin pretreatment
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 mL/kg · intravenousAs given in this study (rat).
Source sentences
Summary
Leakage of Evans blue albumin and increase in brain water content in these brain areas are also markedly reduced with Cerebrolysin pretreatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The possibility that overexpression of heat shock proteins (HSPs) in the CNS represents a neurodestructive signal following hyperthermia was examined in a rat model using a potent neuroprotective drug, Cerebrolysin (Ebewe Pharma, Austria).
Report a problemFND-2063311903
04AnimalAnimal study (in vivo)Efficacy outcome
In heat-stressed rats, Cerebrolysin pretreatment markedly reduced the increase in brain water content versus heat stress without pretreatment.
In plain wordsIn heat-stressed rats, Cerebrolysin pretreatment reduced the increase in brain water compared with heat stress without pretreatment.
Peptide
Cerebrolysin
Outcome
DecreaseBrain water content
Study
ratn: not reported in source
Heat stress
Comparator
Heat stress without Cerebrolysin pretreatment
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 mL/kg · intravenousAs given in this study (rat).
Source sentences
Summary
Leakage of Evans blue albumin and increase in brain water content in these brain areas are also markedly reduced with Cerebrolysin pretreatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The possibility that overexpression of heat shock proteins (HSPs) in the CNS represents a neurodestructive signal following hyperthermia was examined in a rat model using a potent neuroprotective drug, Cerebrolysin (Ebewe Pharma, Austria).
Report a problemFND-2063311904

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Version history

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Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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